Results 111 to 120 of about 212,554 (299)

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Neural repair mechanisms after ischemic stroke

Inflammation and Regeneration
Ischemic stroke triggers inflammation that promotes neuronal injury, leading to disruption of neural circuits and exacerbated neurological deficits in patients.
Koshi Irisa, Takashi Shichita
doaj   +1 more source

Inflammation leads to distinct populations of extracellular vesicles from microglia

Journal of Neuroinflammation, 2018
Background Activated microglia play an essential role in inflammatory responses elicited in the central nervous system (CNS). Microglia-derived extracellular vesicles (EVs) are suggested to be involved in propagation of inflammatory signals and in the ...
Yiyi Yang, Antonio Boza-Serrano, Christopher J. R. Dunning, Bettina Hjelm Clausen, Kate Lykke Lambertsen, Tomas Deierborg   +5 more
doaj   +1 more source

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

Science, 2019
A myeloid cell atlas of neuroinflammation Myeloid cells, such as dendritic cells and macrophages, in the central nervous system (CNS) play critical roles in the initiation and exacerbation of multiple sclerosis (MS). Jordão et al.
M. J. C. Jordão, R. Sankowski, S. Brendecke, Sagar, G. Locatelli, Yi-Heng Tai, Tuan Leng Tay, Eva Schramm, S. Armbruster, N. Hagemeyer, O. Gross, Dominic Mai, Özgün Çiçek, Thorsten Falk, M. Kerschensteiner, Dominic Grün, M. Prinz   +16 more
semanticscholar   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

DNA Subtraction of Selected Phage Repertoires for Efficient Peptide Pathology Biomarker Identification in Neuroinflammation Multiple Sclerosis Model

Biomarker Insights, 2016
To streamline in vivo biomarker discovery, we developed a suppression subtractive DNA hybridization technique adapted for phage-displayed combinatorial libraries of 12 amino acid peptides (PhiSSH).
Karina Vargas-Sanchez, Antonios Vekris, Klaus G. Petry   +2 more
doaj   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Single-centre, prospective cohort to predict optimal individualised treatment response in multiple sclerosis (POINT-MS): a cohort profile

BMJ Open
Purpose Multiple sclerosis (MS) is a chronic neurological condition that affects approximately 150 000 people in the UK and presents a significant healthcare burden, including the high costs of disease-modifying treatments (DMTs). DMTs have substantially
, Baris Kanber, Alan J Thompson, Jeremy Chataway, Frederik Barkhof, Bhavana Solanky, Marios Yiannakas, Olga Ciccarelli, Heather Wilson, Yael Hacohen, Sarah Wright, Karen Chung, Arman Eshaghi, Le Zhang, Declan Chard, Jonathan Stutters, Ferran Prados Carrasco, Claudia Angela Gandini Wheeler-Kingshott, Floriana De Angelis, Charmaine Yam, Zhaleh Khaleeli, Marcello Moccia, Anuriti Aojula, Samih Fourali, Ahmed Toosy, Josephine Swanton, Alessia Bianchi, Wallace Brownlee, Siobhan Leary, Sarmad Al-Araji, Olivia Goodkin, Anna He, Sara Collorone, Valeria Pozzilli, Suraya Mohamud, Ronja Christensen, Alessandro Cruciani, Weaam Hamed, Ahmed Hammam, Davide Maccarrone, Riccardo Nistri, Anestis Passalis, Eirini Samdanidou, Joy Song, Jed Wingrove, Dimitrios Champas, Mohammad Kurd, Elena Panella, Fatima Pansari, Alyssa Toorop, Anand Trip, Chloe Parker, Michaela Stuart, Hanne Haagenrud   +53 more
doaj   +1 more source

Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats [PDF]

, 2020
Jing Yu, Wenna Wang, Nathanael Matei, Xue Li, Jinwei Pang, Jun Mo, Shengpan Chen, Jiping Tang, Min Yan, John H. Zhang   +9 more
openalex   +1 more source

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke

Current Neurology and Neuroscience Reports, 2023
D. Alsbrook, M. Di Napoli, Kunal Bhatia, J. Biller, S. Andalib, Archana Hinduja, R. Rodrigues, Miguel Rodriguez, Sara Y Sabbagh, M. Selim, Maryam H. Farahabadi, Alibay Jafarli, A. Divani   +12 more
semanticscholar   +1 more source