Results 101 to 110 of about 108,380,509 (205)

Inhibitory effect of CP-96,345, a non-peptide neurokinin-1-receptor antagonist, on neurogenic responses of guinea-pig isolated airway smooth muscle

, 1993
The actions of CP-96,345, a non-peptide neurokinin-1 receptor antagonist, on the responses evoked by electrical-field stimulation or by acetylcholine and substance P in guinea-pig tracheal and bronchial muscle strips were examined.
Yuichiro Kamikawa, Yasuo Shimo
core   +1 more source

A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones: Application to the asymmetric syntheses of neurokinin substance P receptor antagonist (-)-L-733,061 and (-)-deoxocassine

, 2004
A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regio- and diastereoselective reductive alkylation of (S)-3-benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols.
Liu, LX, Huang, PQ, Ruan, YP, 黄培强, Guo, ZQ   +4 more
core  

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes. [PDF]

J Biol Chem, 2021
Mai QN, Shenoy P, Quach T, Retamal JS, Gondin AB, Yeatman HR, Aurelio L, Conner JW, Poole DP, Canals M, Nowell CJ, Graham B, Davis TP, Briddon SJ, Hill SJ, Porter CJH, Bunnett NW, Halls ML, Veldhuis NA.   +18 more
europepmc   +1 more source

WIN 64821, a novel neurokinin antagonist produced by an Aspergillus sp. I. Fermentation and isolation

, 1994
WIN 64821, a nonpeptide neurokinin antagonist, was isolated from a strain of Aspergillus sp., SC319. The compound was produced in different fermentation media with greatest yields observed when the culture was grown in a synthetic medium supplemented ...
DR Houck (14530814), DM Sedlock (14530823), A Hong (13638895), AM Gillum (14530859), JE Brownell (14530874), Colin Barrow (13063191)   +5 more
core  

The Neurokinin-1 Receptor Antagonist Aprepitant: An Intelligent Bullet against Cancer? [PDF]

Cancers (Basel), 2020
Muñoz M, Coveñas R.
europepmc   +1 more source

A General Approach to (5S,6R)-6-Alkyl-5-benzyloxy-2-piperidinones:  Application to the Asymmetric Syntheses of Neurokinin Substance P Receptor Antagonist (−)-L-733,061 and (−)-Deoxocassine^†

, 2016
A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regio- and diastereoselective reductive alkylation of (S)-3-benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols.
Liang-Xian Liu (538489), Yuan-Ping Ruan (1909117), Pei-Qiang Huang (1643062), Zheng-Qing Guo (1866235)   +3 more
core   +1 more source

Safety, efficacy, and patient acceptability of single-dose fosaprepitant regimen for the prevention of chemotherapy-induced nausea and vomiting

Patient Preference and Adherence, 2013
Luigi Celio, Francesca Ricchini, Filippo De BraudMedical Oncology Unit 1, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, ItalyAbstract: Control of chemotherapy-induced nausea and vomiting (CINV) is a crucial factor in ...
Celio L, Ricchini F, De Braud F
doaj  

Profile of netupitant/palonosetron (NEPA) fixed dose combination and its potential in the treatment of chemotherapy-induced nausea and vomiting (CINV)

Drug Design, Development and Therapy, 2014
Rudolph M Navari Cancer Care Program, Eastern Europe, World Health Organization, Mishawaka, IN, USA; Indiana University School of Medicine, South Bend, IN, USA; South Bend Medical Services Corporation, IN, USA Abstract: Chemotherapy-induced ...
Navari RM
doaj  

Recent developments in the clinical pharmacology of rolapitant: subanalyses in specific populations

Drug Design, Development and Therapy, 2017
Bernardo Leon Rapoport,1 Matti Aapro,2 Martin R Chasen,3 Karin Jordan,4 Rudolph M Navari,5 Ian Schnadig,6 Lee Schwartzberg7 1The Medical Oncology Centre of Rosebank, Johannesburg, South Africa; 2Breast Center, Genolier Cancer Center, Genolier ...
Rapoport BL, Aapro M, Chasen MR, Jordan K, Navari RM, Schnadig I, Schwartzberg L   +6 more
doaj  

Biochemical and pharmacological activities of SSR 146977, a new potent nonpeptide tachykinin NK₃ receptor antagonist

, 2002
SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. In Chinese hamster ovary cells expressing the human tachykinin NK3 receptor, SSR 146977 inhibited the binding of radioactive neurokinin B to NK3 receptors (Ki = 0.26 nM ...
Vincenzo Proietto, Pol Vilain, Régis Steinberg, Marc Pascal, Christiane Gueudet, Jean-Claude Michaud, Gérard Le Fur, Jean-Pierre Maffrand, Charles Advenier, Emmanuel Naline, Philippe Soubrié, Martine Poncelet, Florence Oury-Donat, Xavier Emonds-Alt, Samira Daoui   +14 more
core   +1 more source