Results 1 to 10 of about 108,375,652 (210)
Neurokinin-1 receptor antagonists as antitumor drugs in gastrointestinal cancer: A new approach [PDF]
The Saudi Journal of Gastroenterology, 2016 Gastrointestinal (GI) cancer is the term for a group of cancers affecting the digestive system. After binding to the neurokinin-1 (NK-1) receptor, the undecapeptide substance P (SP) regulates GI cancer cell proliferation and migration for invasion and ...
Miguel Muñoz, Rafael Coveñas
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Molecules, 2020 Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik +5 more
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The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors
Current Oncology, 2021 Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neurokinin-1 receptor/
Julian Kolorz +13 more
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Efficacy and safety of neurokinin-1 receptor antagonist on cough suppression: a systematic review and meta-analysis [PDF]
Frontiers in PharmacologyIntroductionThe efficacy and safety of neurokinin-1 (NK-1) receptor antagonist in adults with cough remain unclear. Our objective was to systematically assess the efficacy and safety of NK-1 receptor antagonist for cough treatment using the latest ...
Ye Yang +4 more
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Postoperative nausea and vomiting: current concepts, management strategies, and future perspectives [PDF]
Frontiers in PharmacologyPostoperative nausea and vomiting (PONV) remains one of the most common and distressing adverse events after anesthesia and surgery, with important effects on patient comfort, recovery quality, discharge readiness, and healthcare resource use.
Lina Qiu +3 more
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Frontiers in PharmacologyBackgroundAprepitant, fosaprepitant, and netupitant are three common neurokinin-1 receptor antagonists (NK-1RAs) used to prevent chemotherapy-induced nausea and vomiting, following highly or moderately emetogenic chemotherapy.
Chuanli Yang +10 more
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Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis [PDF]
Revista Brasileira de Anestesiologia, 2020 Background: Postoperative Nausea and Vomiting (PONV) is a common complication of general anesthesia. Several kinds of antiemetics, including 5-Hydroxytryptamine3 (5-HT3) receptor antagonists, and Neurokinin-1 (NK-1) receptor antagonists have been used to
Chiaki Murakami +10 more
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Journal of Anaesthesiology Clinical Pharmacology, 2022 A systematic electronic search of MEDLINE, EMBASE, and CINAHL databases aimed at comparing neurokinin-1 receptor antagonists with other antiemetics in their prevention of postoperative nausea and vomiting in adult patients undergoing laparoscopic surgery
John Cavaye +5 more
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The Contribution of Phospholipase C in Vomiting in the Least Shrew (Cryptotis Parva) Model of Emesis
Frontiers in Pharmacology, 2021 Gq and Gβγ protein-dependent phospholipase C (PLC) activation is extensively involved in G protein-coupled receptor (GPCR)-mediated signaling pathways which are implicated in a wide range of physiological and pathological events.
Weixia Zhong, Nissar A. Darmani
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Substance P selectively decreases paired pulse depression in the rat hippocampal slice
BMC Neuroscience, 2005 Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from ...
Davies Stephen N, Wease Kerrie N
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