Results 21 to 30 of about 108,375,652 (210)

Advances in the research and application of neurokinin-1 receptor antagonists. [PDF]

J Zhejiang Univ Sci B
Recently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK ...
Hong X, Ma J, Zheng S, Zhao G, Fu C.
europepmc   +3 more sources

Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance [PDF]

, 2022
SIMPLE SUMMARY: Improving the response, quality of life and survival of oncologic patients through the design and application of the most appropriate treatment for each case is a great scientific challenge.
Téllez, Teresa, Redondo-Bautista, Maximino, Teresa Téllez, Redondo, Maximino, McKenna, Lauraine, Marilina García-Aranda, Maximino Redondo, Téllez-Santana, Teresa, Lauraine McKenna, García Aranda, Marilina, García-Aranda, Marilina   +10 more
core   +1 more source

Neurokinin‐1 receptor antagonists for the prevention of postoperative nausea and vomiting

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2023
AbstractDespite the availability of several classes of antiemetics, postoperative nausea and vomiting (PONV) remains a substantial burden for patients following surgery, resulting in patient dissatisfaction and prolonged stays in post‐anesthesia care units and ultimately increasing the cost of care.
Tricia A. Meyer, Ashraf S. Habib, Deborah Wagner, Tong J. Gan   +3 more
openaire   +2 more sources

Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models [PDF]

, 2007
It has been proposed that substance P and calcitonin gene-related peptide (CGRP) are upregulated in low-threshold myelinated primary afferents after certain types of nerve injury, and that release of substance P from these afferents contributes to the ...
Todd, A.J., Riddell, J.S., Scott, D.T., Hughes, D.I.   +3 more
core   +2 more sources

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]

, 2012
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques, Millar, Robert, Brailly-Tabard, Sylvie, Guiochon-Mantel, Anne, Bouligand, Jerome, Millar, Robert P, George, Jyothis, Tello, Javier, Anderson, Richard, Francou, Bruno, Anderson, Richard A, George, Jyothis T, Tello, Javier A, Tello, Javier; id_orcid   +13 more
core   +1 more source

Autocrine regulation of human sperm motility by tachykinins

Reproductive Biology and Endocrinology, 2010
Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M, Ravina Cristina G, Subiran Nerea, Cejudo-Román Antonio, Fernández-Sánchez Manuel, Irazusta Jon, Garrido Nicolas, Candenas Luz   +7 more
doaj   +1 more source

Efficacy of Vestipitant, A Neurokinin-1 Receptor Antagonist, in Primary Insomnia [PDF]

Sleep, 2013
Investigate the hypnotic effects of repeated doses of neurokinin-1 receptor antagonist, vestipitant, in primary insomnia.Randomized, double-blind, placebo-controlled 28-day parallel-group study.Eleven sleep centers in Germany.One hundred sixty-one patients with primary insomnia.Patients received vestipitant (15 mg) or placebo for 28 days; 2-night ...
Emiliangelo, Ratti, David J, Carpenter, Stefano, Zamuner, Sofia, Fernandes, Lisa, Squassante, Heidi, Danker-Hopfe, Graeme, Archer, Jonathan, Robertson, Robert, Alexander, David G, Trist, Emilio, Merlo-Pich   +10 more
openaire   +2 more sources

Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism [PDF]

, 2011
The abuse potential of opioids may be due to their reinforcing and rewarding effects, which may be attenuated by neurokinin-1 receptor (NK1R ...
Krouse, M. C.,, Heilig, M., Malanga, C. J.,, M. C. Krouse, C. J. Malanga, Robinson, J. E.,, J. E. Robinson, M. Heilig, Fish, E. W., Thorsell, Annika,, E. W. Fish, Robinson, J. E., Heilig, Marcus,, Malanga, C. J., Fish, E. W.,, Thorsell, A., Krouse, M. C., A. Thorsell   +17 more
core   +1 more source

Anti-platelet therapy: ADP receptor antagonists. [PDF]

, 2011
The P2Y(12) receptor on platelets with which ADP interacts has an important role in promoting platelet function and thereby platelet involvement in both haemostasis and thrombosis.
Heptinstall, S, Wijeyeratne, YD, Stan Heptinstall, Yanushi Dullewe Wijeyeratne   +3 more
core   +1 more source

Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting [PDF]

British Journal of Anaesthesia, 2009
Despite major advances, emesis remains a major problem in the context of cancer chemotherapy and in the postoperative period. A better understanding of the relevant neurocircuitry, especially the central pattern generator responsible for emesis and the central role of substance P, led to the development of a new class of antiemetics: the neurokinin-1 ...
Diemunsch, P., Joshi, G. P., Brichant, Jean-François   +2 more
openaire   +2 more sources