Results 21 to 30 of about 160,899 (200)

NK1 receptor antagonists versus other antiemetics in the prevention of postoperative nausea and vomiting following laparoscopic surgical procedures: a systematic review and meta-analysis

Journal of Anaesthesiology Clinical Pharmacology, 2022
A systematic electronic search of MEDLINE, EMBASE, and CINAHL databases aimed at comparing neurokinin-1 receptor antagonists with other antiemetics in their prevention of postoperative nausea and vomiting in adult patients undergoing laparoscopic surgery
John Cavaye, Bryan Dai, Karthik Gurunathan, Rachel M Weir, Stephanie Yerkovich, Usha Gurunathan   +5 more
doaj   +1 more source

The Contribution of Phospholipase C in Vomiting in the Least Shrew (Cryptotis Parva) Model of Emesis

Frontiers in Pharmacology, 2021
Gq and Gβγ protein-dependent phospholipase C (PLC) activation is extensively involved in G protein-coupled receptor (GPCR)-mediated signaling pathways which are implicated in a wide range of physiological and pathological events.
Weixia Zhong, Nissar A. Darmani
doaj   +1 more source

Substance P selectively decreases paired pulse depression in the rat hippocampal slice

BMC Neuroscience, 2005
Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from ...
Davies Stephen N, Wease Kerrie N
doaj   +1 more source

Neurokinin-1 receptor activation in globus pallidus

Frontiers in Neuroscience, 2009
The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine
Lei Chen, Lei Chen, Qiao-Ling Cui, Qiao-Ling Cui, Wing-Ho Yung   +4 more
doaj   +1 more source

Neurokinin-1 receptor antagonists: review of their role for the prevention of chemotherapy-induced nausea and vomiting in adults

Expert Review of Clinical Pharmacology, 2019
Introduction: The addition of neurokinin-1 receptor antagonists (NK1RAs) to standard prophylaxis of 5-hydroxytryptamine-3 RA (5-HT3RA) plus dexamethasone more effectively prevents chemotherapy-induced nausea and vomiting (CINV) associated with highly and
M. Karthaus, X. Schiel, C. Ruhlmann, L. Celio   +3 more
semanticscholar   +1 more source

Autocrine regulation of human sperm motility by tachykinins

Reproductive Biology and Endocrinology, 2010
Background We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa.
Pinto Francisco M, Ravina Cristina G, Subiran Nerea, Cejudo-Román Antonio, Fernández-Sánchez Manuel, Irazusta Jon, Garrido Nicolas, Candenas Luz   +7 more
doaj   +1 more source

Efficacy of Vestipitant, A Neurokinin-1 Receptor Antagonist, in Primary Insomnia [PDF]

Sleep, 2013
Investigate the hypnotic effects of repeated doses of neurokinin-1 receptor antagonist, vestipitant, in primary insomnia.Randomized, double-blind, placebo-controlled 28-day parallel-group study.Eleven sleep centers in Germany.One hundred sixty-one patients with primary insomnia.Patients received vestipitant (15 mg) or placebo for 28 days; 2-night ...
Emiliangelo, Ratti, David J, Carpenter, Stefano, Zamuner, Sofia, Fernandes, Lisa, Squassante, Heidi, Danker-Hopfe, Graeme, Archer, Jonathan, Robertson, Robert, Alexander, David G, Trist, Emilio, Merlo-Pich   +10 more
openaire   +2 more sources

Neurokinin 1 receptor antagonists exhibit peripheral effects in prurigo nodularis including reduced ERK1/2 activation

Journal of the European Academy of Dermatology and Venereology, 2019
Aprepitant is a neurokinin 1 receptor (NK1R) antagonist used for its antipruritic properties in dermatoses and systemic diseases. The mode of action is still unclear.
Konstantin Agelopoulos, F. Rülander, J. Dangelmaier, T. Lotts, Nani Osada, D. Metze, T. Luger, Karin Loser, Sonja Ständer   +8 more
semanticscholar   +1 more source

NK-1 Receptor Antagonists and Pruritus: Review of Current Literature

Dermatology and Therapy, 2019
The discovery of the first neurokinin 1 (NK-1) receptor antagonist was a turning point in the prevention of chemotherapy-induced nausea and vomiting. The NK-1 antagonists are a novel class of drugs that possess antidepressant, anxiolytic, and antiemetic ...
Marcelina Pojawa-Gołąb, Kamila Jaworecka, Adam Reich   +2 more
doaj   +1 more source

Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Background:Chemotherapy-caused nausea and vomiting is a health problem in cancer patients. Olanzapine is used with serotonin receptor antagonists plus dexamethasone post Neurokinin 1 receptor antagonists as the antiemetic.
Ghufran salah ahmed, khadim ali khadim2, nabeel mudheher talib   +2 more
doaj   +1 more source