Results 11 to 20 of about 108,375,652 (210)
Neurokinin 1 Receptor Antagonists for Pruritus. [PDF]
Drugs, 2021 Pruritus, commonly known as itch, is a very common symptom in numerous dermatological disorders and systemic diseases. It can manifest as acute, or when lasting longer than 6 weeks, it is considered chronic and can lead to significant distress and reduced quality-of-life of those suffering.
Alam M +3 more
europepmc +5 more sources
Neurokinin-1 Receptor Antagonists against Hepatoblastoma. [PDF]
Cancers (Basel), 2019 Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. New anti-HB strategies must be urgently developed.
Muñoz M, Rosso M, Coveñas R.
europepmc +10 more sources
Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations [PDF]
British Journal of Psychiatry, 2007 SummaryBased upon animal experiments and early clinical trials, neurokinin-1 receptor antagonists showed promise as novel antidepressants. Subsequently, however, more extensive clinical trials did not reveal evidence of efficacy in depression.
Hafizi, S, Chandra, P, Cowen, J
openaire +4 more sources
Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat [PDF]
Journal of Occupational Medicine and Toxicology, 2008 Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A +3 more
doaj +2 more sources
Neurokinin-1 receptor activation in globus pallidus
Frontiers in Neuroscience, 2009 The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine
Lei Chen +4 more
doaj +2 more sources
Neurokinin-1 Receptor Antagonists as Anticancer Drugs
Letters in Drug Design & Discovery, 2019 Background::Human tumor cells lines and tumor samples overexpress the neurokinin-1 receptor (NK-1R). Substance P (SP), after binding to NK-1Rs, induces tumor cell proliferation, an antiapoptotic effect and promotes angiogenesis and the migration of cancer cells for invasion and metastasis.Methods: :In contrast, NK-1R antagonists block the previous ...
Muñoz Sáez, Miguel, Coveñas, Rafael
openaire +3 more sources
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists [PDF]
Nature Communications, 2019 Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically ...
Jendrik Schöppe +6 more
doaj +2 more sources
Glioma and Neurokinin-1 Receptor Antagonists: A New Therapeutic Approach
Anti-Cancer Agents in Medicinal Chemistry, 2019 Background:In adults, the most lethal and frequent primary brain tumor is glioblastoma. Despite multimodal aggressive therapies, the median survival time after diagnosis is around 15 months. In part, this is due to the blood-brain barrier that restricts common treatments (e.g., chemotherapy). Unfortunately, glioma recurs in 90% of patients.
Miguel, Muñoz, Rafael, Coveñas
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Investigational New Drugs, 2018 The substance P/neurokinin-1 receptor system has been implicated in tumor cell proliferation. Neurokinin-1 receptor has been identified in different solid tumors but not frequently in hematopoietic malignant cells. We investigated the presence of the Neurokinin-1 receptor in acute myeloid leukemia cell lines (KG-1 and HL-60), demonstrating that acute ...
Molinos-Quintana, A. +6 more
openaire +4 more sources
The Repurposing of Non-Peptide Neurokinin-1 Receptor Antagonists as Antitumor Drugs: An Urgent Challenge for Aprepitant. [PDF]
Int J Mol Sci, 2023 The substance P (SP)/neurokinin-1 receptor (NK-1R) system is involved in cancer progression. NK-1R, activated by SP, promotes tumor cell proliferation and migration, angiogenesis, the Warburg effect, and the prevention of apoptosis.
Coveñas R +3 more
europepmc +2 more sources