Neurokinin‐1 receptor antagonists for the prevention of postoperative nausea and vomiting
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2023 Despite the availability of several classes of antiemetics, postoperative nausea and vomiting (PONV) remains a substantial burden for patients following surgery, resulting in patient dissatisfaction and prolonged stays in post‐anesthesia care units and ...
T. Meyer, A. Habib, D. Wagner, T. Gan
semanticscholar +3 more sources
Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting [PDF]
British Journal of Anaesthesia, 2009 Despite major advances, emesis remains a major problem in the context of cancer chemotherapy and in the postoperative period. A better understanding of the relevant neurocircuitry, especially the central pattern generator responsible for emesis and the central role of substance P, led to the development of a new class of antiemetics: the neurokinin-1 ...
G P Joshi, P Diemunsch, J-F Brichant
exaly +4 more sources
Overview of the neurokinin-1 receptor antagonists
Biotarget, 2017 Neurokinin-1 (NK-1) receptor antagonists block substance P-mediated NK-1 receptors which are present in the abdominal vagus, the brainstem, and the area postrema in the brainstem.
R. Navari
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Effect of Selective 5-Hydroxytryptamine-3 Receptor and Neurokinin-1 Receptor Antagonists on Hemodynamic Changes and Arrhythmogenic Potential in Patients Receiving Chemotherapy: A Retrospective, Observational Study [PDF]
Journal of Clinical MedicineUtku Burak Bozbulut +2 more
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Advances in the research and application of neurokinin-1 receptor antagonists. [PDF]
J Zhejiang Univ Sci BRecently, the substance P (SP)/neurokinin-1 receptor (NK-1R) system has been found to be involved in various human pathophysiological disorders including the symptoms of coronavirus disease 2019 (COVID-19). Besides, studies in the oncological field have demonstrated an intricate correlation between the upregulation of NK-1R and the activation of SP/NK ...
Hong X, Ma J, Zheng S, Zhao G, Fu C.
europepmc +3 more sources
Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis [PDF]
Revista Brasileira de Anestesiologia, 2020 Background: Postoperative Nausea and Vomiting (PONV) is a common complication of general anesthesia. Several kinds of antiemetics, including 5-Hydroxytryptamine3 (5-HT3) receptor antagonists, and Neurokinin-1 (NK-1) receptor antagonists have been used to
Chiaki Murakami +10 more
doaj +6 more sources
The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors
Current Oncology, 2021 Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neurokinin-1 receptor/
Julian Kolorz +13 more
doaj +1 more source
Neurokinin-1 Receptor (NK-1R) Antagonists as a New Strategy to Overcome Cancer Resistance
Cancers, 2022 Simple Summary Improving the response, quality of life and survival of oncologic patients through the design and application of the most appropriate treatment for each case is a great scientific challenge. Given the role of the axis formed by Substance P
M. García-Aranda +3 more
semanticscholar +1 more source
Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations [PDF]
British Journal of Psychiatry, 2007 SummaryBased upon animal experiments and early clinical trials, neurokinin-1 receptor antagonists showed promise as novel antidepressants. Subsequently, however, more extensive clinical trials did not reveal evidence of efficacy in depression.
S. Hafizi, Prakash Chandra, P. Cowen
semanticscholar +4 more sources
Molecules, 2020 Aprepitant, a lipophilic and small molecular representative of neurokinin 1 receptor antagonists, is known for its anti-proliferative activity on numerous cancer cell lines that are sensitive to Substance P mitogen action.
Paweł K. Halik +5 more
doaj +1 more source