Results 31 to 40 of about 160,899 (200)

Effect of endogenous substance P on visceral afferent signal integration in the nucleus tractus solitaries of rat brainstem slices

IBRO Neuroscience Reports, 2023
In the first synapse of the blood-pressure-regulating pathway, a neurokinin (NK) family peptide substance P (SP) is release with an excitatory neurotransmitter, glutamate, to enhance the sensitivity of the baroreflex responses.
Zhenhua Jin, Jin-Bae Kim, Young-Ho Jin
doaj   +1 more source

Neurokinin-1 receptor antagonists: A new revolution in antiretroviral treatment?

Indian J Sex Transm Dis AIDS, 2016
Grewal US.
europepmc   +4 more sources

Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat

Journal of Occupational Medicine and Toxicology, 2008
Background Platelet activating factor and tachykinins (substance P, neurokinin A, neurokinin B) are important mediators contributing to increased airway secretion in the context of different types of respiratory diseases including acute and chronic ...
Groneberg David A, Staats Petra, Schmidt Rene, Wagner Ulrich   +3 more
doaj   +1 more source

Electroacupuncture alleviates inflammatory pain via adenosine suppression and its mediated substance P expression [PDF]

Arquivos de Neuro-Psiquiatria, 2020
Background: Acupuncture has been widely used for alleviating pain. However, its mechanisms remain largely enigmatic. Objective: In the present study, we focused on whether the analgesic effect of electroacupuncture is related to its regulation on ...
Rong yi ZHANG, Ben fan ZHU, Li kui WANG, Yang SONG, Jia gui ZHAO, Yan GUO, Long ZHAO, Shi CHEN   +7 more
doaj   +1 more source

Recent advances in pharmacotherapy of chemotherapy-induced nausea and vomiting.

Journal of Advanced Pharmaceutical Technology & Research, 2012
Nausea and vomiting remain among the most feared side effects of chemotherapy for cancer patients. Significant progress has been made in the last 15 years in developing more effective and better-tolerated measures to minimize chemotherapy-induced nausea ...
Prasan R Bhandari
doaj   +2 more sources

Efficacy and Safety of Neurokinin-1 Receptor Antagonists for Prevention of Chemotherapy-Induced Nausea and Vomiting: Systematic Review and Meta-analysis of Randomized Controlled Trials.

Asian Pacific Journal of Cancer Prevention, 2016
OBJECTIVES Can addition of neurokinin-1 receptor antagonists (NK1-RAs) be considered as an ideal strategy for the prevention of chemotherapy-induced nausea and vomiting (CINV)? Researchers differ on this question.
D. Yuan, Qian Li, Qin Zhang, Xinwu Xiao, Yan-wen Yao, Y. Zhang, Yan-ling Lv, Hong-Bin Liu, T. Lv, Yong Song   +9 more
semanticscholar   +1 more source

Presynaptic control of nociceptor signalling: Differential influence of Mu Opioid and GABAergic Systems

Pain Research and Management, 2000
The relative contribution of pre- and postsynaptic controls to the flow of nociceptive information at the level of the spinal cord has been one of Ron Melzack's longstanding interests and a key issue in the formulation of the gate control theory.
Ruth C Riley, Jodie A Trafton, Allan I Basbaum   +2 more
doaj   +1 more source

Elevated Neurokinin-1 Receptor Expression in Uterine Products of Conception Is Associated With First Trimester Miscarriages

Frontiers in Physiology, 2020
BackgroundMiscarriage is a common complication of early pregnancy, mostly occurring in the first trimester. However, the etiological factors and prognostic and diagnostic biomarkers are not well known.
Ahmad Alwazzan, Riffat Mehboob, Riffat Mehboob, Amber Hassan, Shahida Perveen, Sadaf, Syed Amir Gilani, Fridoon Jawad Ahmad, Fridoon Jawad Ahmad, Imrana Tanvir, Masroor Elahi Babar, Muhammad Akram Tariq, Gibran Ali, Shehla Javed Akram, Rizwan Ullah Khan, Javed Akram, Javed Akram   +16 more
doaj   +1 more source

Substance P Increases the Excitability of Dorsal Motor Nucleus of the Vagus Nerve via Inhibition of Potassium Channels

Frontiers in Neuroscience, 2022
Increases in the substance P (SP) concentration in the medial portion of the dorsal motor nucleus of the vagus nerve (mDMV) in the brainstem are closely associated with chemotherapy induced nausea and vomiting (CINV). However, the underlying cellular and
Eunhee Yang, Woojin Kim, Yong Seek Park, Young-Ho Jin   +3 more
doaj   +1 more source

Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance Sustained GPCR signaling from endosomes mediates pathologies, including pain. Optimal therapy requires development of antagonists that penetrate cells, are retained in endosomes, and disrupt endosomal signaling.
Alan Hegron, C. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, H. Huebner, D. Weikert, J. Rientjes, N. Veldhuis, D. Poole, D. Jensen, A. Thomsen, B. Schmidt, Wendy L. Imlach, Peter Gmeiner, N. Bunnett   +16 more
semanticscholar   +1 more source