Results 31 to 40 of about 108,375,652 (210)

NK-1 Receptor Antagonists and Pruritus: Review of Current Literature

Dermatology and Therapy, 2019
The discovery of the first neurokinin 1 (NK-1) receptor antagonist was a turning point in the prevention of chemotherapy-induced nausea and vomiting. The NK-1 antagonists are a novel class of drugs that possess antidepressant, anxiolytic, and antiemetic ...
Marcelina Pojawa-Gołąb, Kamila Jaworecka, Adam Reich   +2 more
doaj   +1 more source

Therapeutic study of the nausea and vomiting caused by chemotherapy medications by olanzapine to triple antiemetic therapy in Iraqi cancer patients

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023
Background:Chemotherapy-caused nausea and vomiting is a health problem in cancer patients. Olanzapine is used with serotonin receptor antagonists plus dexamethasone post Neurokinin 1 receptor antagonists as the antiemetic.
Ghufran salah ahmed, khadim ali khadim2, nabeel mudheher talib   +2 more
doaj   +1 more source

The Effects of Serotonin Receptor Antagonists on Contraction and Relaxation Responses Induced by Electrical Stimulation in the Rat Small Intestine [PDF]

, 2014
Background: The main source of 5-HT in body is in enterchromafin cells of intestine, different studies mentioned different roles for endogenous 5-HT and receptors involved and it is not clearified the mechanism of action of endogenous 5-HT. Objectives:
Javid, Farideh A., Mashhadi, Farzaneh Farajian, Naylor, Robert J.   +2 more
core   +4 more sources

Effect of endogenous substance P on visceral afferent signal integration in the nucleus tractus solitaries of rat brainstem slices

IBRO Neuroscience Reports, 2023
In the first synapse of the blood-pressure-regulating pathway, a neurokinin (NK) family peptide substance P (SP) is release with an excitatory neurotransmitter, glutamate, to enhance the sensitivity of the baroreflex responses.
Zhenhua Jin, Jin-Bae Kim, Young-Ho Jin
doaj   +1 more source

Recent advances in pharmacotherapy of chemotherapy-induced nausea and vomiting.

Journal of Advanced Pharmaceutical Technology & Research, 2012
Nausea and vomiting remain among the most feared side effects of chemotherapy for cancer patients. Significant progress has been made in the last 15 years in developing more effective and better-tolerated measures to minimize chemotherapy-induced nausea ...
Prasan R Bhandari
doaj   +2 more sources

Neurokinin-1 receptor antagonist rolapitant suppresses anxiety and alcohol intake produced by repeated withdrawal episodes

, 2022
Neurokinin-1 receptor (NK1r) antagonists have been shown to suppress operant self-administration of alcohol, voluntary alcohol consumption and stress-induced reinstatement of alcohol-seeking behaviour.
Anokhin, P. K., Kokhan, V. S., Abaimov, D. A., Shamakina, I. Yu., Deykin, A. V., Soldatov, V. O.   +5 more
core   +1 more source

Electroacupuncture alleviates inflammatory pain via adenosine suppression and its mediated substance P expression [PDF]

Arquivos de Neuro-Psiquiatria, 2020
Background: Acupuncture has been widely used for alleviating pain. However, its mechanisms remain largely enigmatic. Objective: In the present study, we focused on whether the analgesic effect of electroacupuncture is related to its regulation on ...
Rong yi ZHANG, Ben fan ZHU, Li kui WANG, Yang SONG, Jia gui ZHAO, Yan GUO, Long ZHAO, Shi CHEN   +7 more
doaj   +1 more source

Presynaptic control of nociceptor signalling: Differential influence of Mu Opioid and GABAergic Systems

Pain Research and Management, 2000
The relative contribution of pre- and postsynaptic controls to the flow of nociceptive information at the level of the spinal cord has been one of Ron Melzack's longstanding interests and a key issue in the formulation of the gate control theory.
Ruth C Riley, Jodie A Trafton, Allan I Basbaum   +2 more
doaj   +1 more source

Elevated Neurokinin-1 Receptor Expression in Uterine Products of Conception Is Associated With First Trimester Miscarriages

Frontiers in Physiology, 2020
BackgroundMiscarriage is a common complication of early pregnancy, mostly occurring in the first trimester. However, the etiological factors and prognostic and diagnostic biomarkers are not well known.
Ahmad Alwazzan, Riffat Mehboob, Riffat Mehboob, Amber Hassan, Shahida Perveen, Sadaf, Syed Amir Gilani, Fridoon Jawad Ahmad, Fridoon Jawad Ahmad, Imrana Tanvir, Masroor Elahi Babar, Muhammad Akram Tariq, Gibran Ali, Shehla Javed Akram, Rizwan Ullah Khan, Javed Akram, Javed Akram   +16 more
doaj   +1 more source

Substance P Increases the Excitability of Dorsal Motor Nucleus of the Vagus Nerve via Inhibition of Potassium Channels

Frontiers in Neuroscience, 2022
Increases in the substance P (SP) concentration in the medial portion of the dorsal motor nucleus of the vagus nerve (mDMV) in the brainstem are closely associated with chemotherapy induced nausea and vomiting (CINV). However, the underlying cellular and
Eunhee Yang, Woojin Kim, Yong Seek Park, Young-Ho Jin   +3 more
doaj   +1 more source