Results 171 to 180 of about 108,380,509 (205)

Neurokinin 1 receptor antagonists--current prospects.

Current opinion in drug discovery & development, 2007
The isolation of substance P (SP) in 1931, and the later discovery of its preferred neurokinin (NK)1 receptor, led to an intense research effort aimed at elucidating the biological role of SP, particularly within the central nervous system. There is now a large body of evidence to support the hypothesis that SP is one of the most important ...
Giuseppe, Alvaro, Romano, Di Fabio
openaire   +1 more source

Spiro-piperidine non-peptide neurokinin-1 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 1995
Abstract The synthesis and activity of a novel spiro-piperidine non-peptide antagonist (2) of the neurokinin-1 (NK 1 ) receptor is described. Despite having essentially the same solution conformation as CP 99,994 (1) at physiological pH, (2) has reduced affinity for the NK 1 receptor.
D.R. Armour, S.P. Watson, N.A. Pegg, N.M. Heron, D. Middlemiss, C. Chan, T.J. Cholerton, T. Hubbard, M.V. Vinader, H.G. Davies, J.D. Cocker, D.E. Bays, P. Ward   +12 more
openaire   +1 more source

[Neurokinin 1 receptor antagonists--between hope and disappointment].

Medizinische Monatsschrift fur Pharmazeuten, 2006
Substance P (SP)/Neurokinin 1 (NK1) receptor pathways have been repeatedly implicated in the pathophysiology of central, pulmonary, and gastric disorders. A large body of evidence that has been generated from animal experiments indicates that treatment with selective NK1 receptor antagonists might be effective in the treatment of certain forms of ...
Kristin, Rost, Franziska, Fleischer, Karen, Nieber   +2 more
openaire   +1 more source

Neurokinin Receptor Antagonist, Fezolinetant, for Treatment of Menopausal Vasomotor Symptoms

Journal of Clinical Endocrinology and Metabolism, 2023
Joann V Pinkerton, Andrew M Kaunitz
exaly  

Recent Advances in Neurokinin-3 Receptor Antagonists

Expert Opinion on Therapeutic Patents, 2000
Luca F Raveglia
exaly  

Neurokinin Receptor Antagonists

Expert Opinion on Therapeutic Patents, 1999
Christopher J Swain
exaly  

Neurokinin-1 Receptor Antagonists in Lung Cancer Therapy

Letters in Drug Design & Discovery, 2017
Miguel Munoz, Marisa Rosso, Rafael Covenas   +2 more
openaire   +1 more source

COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF

2020
XIANG JIA-NING, XU XUESONG, FENG YI, LIU XIANBO, ENG WAI-SI   +4 more
openaire   +6 more sources

Neurokinin-1 Receptors Located in Human Retinoblastoma Cell Lines: Antitumor Action of Its Antagonist, L-732,138

Investigative Ophthalmology and Visual Science, 2007
Rafael Coveñas, Miguel Muñoz, Miguel Ángel González-Moles   +2 more
exaly  

SR 48968, a Neurokinin a (NK2) Receptor Antagonist

Regulatory Peptides, 1993
Gérard le Fur, Luciano Manara, Xavier Emonds-Alt   +2 more
exaly