Results 171 to 180 of about 18,865 (225)
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Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001Peribronchial smooth muscle constriction causes airway stretch, an important mechanical force in developing lung. Little is known about factors influencing these spontaneously active muscle elements. We measured contractile activity of neurokinin (NK) receptors on fetal intrapulmonary smooth muscle by tracheal perfusion assay ( n = 11).
K J, Haley +7 more
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The effects of neurokinin A, neurokinin B, and eledoisin on substance P analysis
Journal of Clinical Monitoring, 1991Commercial sources for neuropeptide radioimmunoassays have made this sensitive tool available to clinical investigators for monitoring the potential involvement of neuropeptides in pain modulation. We measured substance P-like immunoreactivity in the plasma, saliva, and pericardial fluid of subjects with and without pain (chronic and acute) to ...
R J, Naukam +3 more
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Relative bronchoconstrictor activity of neurokinin A and neurokinin A fragments in guinea pigs
Journal of Applied Physiology, 1991We examined the effect of rapid intravenous infusion of neurokinin A (NKA) and selected COOH-terminal NKA fragments on pulmonary conductance (GL) and dynamic compliance in anesthetized mechanically ventilated guinea pigs. The rank order of the dose of peptide required to reduce GL by 50% (ED50GL) was NKA = NKA2–10 = NKA3–10 = NKA4–10 less than NKA5–10
S A, Shore, J M, Drazen
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Structure-Activity Study of Neurokinins: Antagonists for the Neurokinin-2 Receptor
Pharmacology, 2008A series of 21 peptides were synthesized and tested in a variety of isolated organs in order to determine their potential as neurokinin-2 (NK-2) antagonists. The peptides have been tested in the three monoreceptor systems, the dog carotid artery (NK-1), the rabbit pulmonary artery (NK-2) and the rat portal vein (NK-3) as well as on other preparations ...
S. Dion +12 more
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Neurokinin-1 and neurokinin-3 receptors in primate substantia nigra
Neuroscience Research, 2007Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral level in squirrel monkeys ...
Martin, Lévesque +4 more
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Developmental expression of neurokinin‐1 and neurokinin‐3 receptors in the rat retina
The Journal of Comparative Neurology, 2000Tachykinin (TK) peptides act on retinal neurons through neurokinin (NK) receptors. We examined the expression of neurokinin-1 (NK1; the substance P receptor), NK3 [the neurokinin B (NKB) receptor], and TK peptides in developing rat retinas. NK1 immunolabeling was found in newborn retinas in rare amacrine cells and in putative ganglion cells.
CASINI, GIOVANNI +3 more
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Biofizika, 2005
The spatial structure of a neurokinin B molecule was investigated by the method of theoretical conformational analysis. The conformational analysis of this molecule indicated that the possible structure of neurokinin B under polar conditions may be described by five families of low-energy conformations possessing a conformationally relatively rigid C ...
G A, Agaeva, N N, Kerimli, N M, Godzhaev
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The spatial structure of a neurokinin B molecule was investigated by the method of theoretical conformational analysis. The conformational analysis of this molecule indicated that the possible structure of neurokinin B under polar conditions may be described by five families of low-energy conformations possessing a conformationally relatively rigid C ...
G A, Agaeva, N N, Kerimli, N M, Godzhaev
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Allergie et immunologie, 1993
Neurokinins are a family of peptides which are released from sensory nerves. This family involves substance P, neurokinin A and B which stimulate neurokinin-NK1, -NK2 and -NK3 receptors respectively. The neurokinins as well as C.G.R.P. (calcitonin gene related peptide) and V.I.P.
C, Advenier, P, Devillier
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Neurokinins are a family of peptides which are released from sensory nerves. This family involves substance P, neurokinin A and B which stimulate neurokinin-NK1, -NK2 and -NK3 receptors respectively. The neurokinins as well as C.G.R.P. (calcitonin gene related peptide) and V.I.P.
C, Advenier, P, Devillier
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Neurokinin Receptor Antagonism: A Patent Review (2014-Present)
Expert Opinion on Therapeutic Patents, 2020Rafael Coveñas, Miguel Muñoz
exaly