Results 101 to 110 of about 3,097,745 (309)

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Machine learning prediction of discharge destination in patients with Parkinson’s disease; a nationwide cohort study

npj Parkinson's Disease
Risk stratification during hospitalization may support real-world discharge planning. We developed and validated machine learning models and an interpretable risk score to predict discharge destination among patients hospitalized with Parkinson’s disease
Hikaru Kamo, Tejas R. Mehta, Matthew Remz, Rachael M. Burke, Anne Brooks, Adrianne Smiley, Michael S. Okun, Christopher W. Hess   +7 more
doaj   +1 more source

Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA stratified by age and renal function: CHANCE-2 trial substudy

Renal Failure
Objective To compare the efficacy and safety of ticagrelor versus clopidogrel in stroke patients who were CYP2C19 loss-of-function (LOF) carriers stratified by age and renal function.Methods Patients in the CHANCE-2 trial were randomized to ticagrelor ...
Yu Wu, Yilun Zhou, Yuesong Pan, Aoming Jin, Xia Meng, Hao Li, Yilong Wang, Yong Jiang, Yongjun Wang   +8 more
doaj   +1 more source

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To (1) validate GAD65‐ELISA detection and quantification for type 1 diabetes mellitus and autoimmune neurological diagnoses, (2) correlate ELISA results (reference range < 5 IU/mL) with established radioimmunoprecipitation assay (RIA; ≤ 0.02 nmol/L), and (3) define ELISA clinical utility and pitfalls.
Andrew McKeon, Dana Olofson, Diana Anissian, Divyanshu Dubey, Eoin P. Flanagan, Max C. Herman, Sarosh R. Irani, Daniel H. Lachance, Maria A. Willrich, Sean Pittock, John R. Mills, Anastasia Zekeridou   +11 more
wiley   +1 more source

Standards of care for people with disabling (progressive and static) neurological conditions in the hospital and community: standards of care for people with disabling progressive and static neurological conditions in the hospital and community.

, 2001
Neurological conditions are common, affecting over 500,000 people in the Irish population. Recent advances in the neurosciences have improved the outlook many conditions, as major breakthroughs have been achieved. Standing pathogenesis, the prospect of
Neurological Alliance of Ireland
core  

Significance of Brain Glucose Hypometabolism, Altered Insulin Signal Transduction, and Insulin Resistance in Several Neurological Diseases

, 2022
Several neurological diseases share pathological alterations, even though they differ in their etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress, mitochondrial dysfunction and amyloidosis are biological events found in those
Pozo, Miguel Ángel, Velázquez, Esther, Ruiz Albusac, Juan Miguel, Hurtado Carneiro, Verónica, Ávila, Jesús, Pozo García, Miguel Ángel, Blázquez Fernández, Enrique, Blázquez, Enrique, LeBaut-Ayuso, Yannick, Angel Pozo, Miguel, Le Baut Ayuso, Yannick, Miguel Ruiz-Albusac, Juan, Ruiz-Albusac, Juan Miguel, Gómez Oliver, Francisca, García-García, Luis, García García, José Luis, Gómez-Oliver, Francisca, Velázquez Sánchez, Esther, Hurtado-Carneiro, Verónica   +18 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Standards of care for people with non-physically disabling neurological (and associated psychiatric) conditions.

, 2001
The standards of care recommended within this document are based on the collective experiences and recommendations of the Neurological Alliance of Ireland, in conjunction with members of the Elan Neurology Advisory Board (see Appendix B).
Neurological Alliance of Ireland
core  

Neurological manifestations and implications of COVID-19 pandemic.

, 2020
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide, with a vast majority of confirmed cases presenting with respiratory symptoms.
Fischer, Urs Martin, Chan, Amanda C, Zand, Ramin, Voumvourakis, Konstantinos I, Schellinger, Peter D, Kelly, Peter, Alexandrov, Andrei V, Köhrmann, Martin, Caso, Valeria, Palaiodimou, Lina, Cordonnier, Charlotte, Sharma, Vijay K, Grigoriadis, Nikolaos, Katsanos, Aristeidis H, Sarraj, Amrou, Tsiodras, Sotirios, Tsivgoulis, Georgios, Molina, Carlos   +17 more
core   +1 more source

Responsive deep brain stimulation for the treatment of Tourette syndrome

Scientific Reports
To report the results of ‘responsive’ deep brain stimulation (DBS) for Tourette syndrome (TS) in a National Institutes of Health funded experimental cohort.
Michael S. Okun, Jackson Cagle, Julieth Gomez, Dawn Bowers, Joshua Wong, Kelly D. Foote, Aysegul Gunduz   +6 more
doaj   +1 more source