Results 81 to 90 of about 3,232,639 (308)

Constipation in neurological diseases [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2003
Hippocrates noted that "it is a general rule, that intestines become sluggish with age", though the precise mechanisms for this association remains uncertain even today.
K, Winge, D, Rasmussen, L M, Werdelin
openaire   +2 more sources

NEUROLOGICAL DISEASES - AS A SOCIAL AND HYGIENIC PROBLEM

, 2022
Neurological diseases are pathologies of the organs of the central and peripheral nervous system. They are often the cause of disability and death of the population.
Rasulova Nilufar,Makhmudova Maftuna
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Immunotherapy for neurological diseases

, 2008
The burden of neurological diseases in western societies has accentuated the need to develop effective therapies to stop the progression of chronic neurological diseases.
Delgado, M. (Mario), Schwartz, M. (Michal), Villoslada, P. (Pablo), Moreno, B. (Beatriz), Avila, J. (Jesús), Obeso, J.A. (José A.), Pablos, J.L. (José L.), Acarin, L. (Laia), Khoury, S.J. (Samia J.), Uccelli, A. (Antonio), McGeer, P. (Patrick), Montalban, X. (Xavier), Ferrer, I. (Isidro), Martino, G. (Gianvito), Appel, S. (Stanley), Rivest, S. (Serge), Melero, I. (Ignacio)   +16 more
core   +2 more sources

Trigeminal neuralgia and posterior fossa meningioma: case report and review of literature

Egyptian Journal of Neurosurgery, 2019
Trigeminal neuralgia may be idiopathic or may involve other causes. It can be secondary to posterior fossa tumors many times. In the present case, posterior fossa meningioma was detected with trigeminal neuralgia together. However, relevant meningioma is
Hasan Burak Gunduz, Yaser Ozgunduz, Abdullah Emre Tacyildiz, Erhan Emel, Murad Asilturk   +4 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The potential roles of m6A modification in regulating the inflammatory response in microglia

Journal of Neuroinflammation, 2021
Background Microglia are key regulators of the inflammatory response in the brain. Adenosine in RNAs can be converted to m6A (N6-methyladenosine), which regulates RNA metabolism and functions as a key epitranscriptomic modification.
Qi Li, Shaohong Wen, Weizhen Ye, Shunying Zhao, Xiangrong Liu   +4 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells

Neurobiology of Disease, 2015
Heterozygous mutations in GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), are a major risk factor for sporadic Parkinson's disease (PD).
Giulia Ambrosi, Cristina Ghezzi, Roberta Zangaglia, Giovanna Levandis, Claudio Pacchetti, Fabio Blandini   +5 more
doaj   +1 more source