Results 81 to 90 of about 717,165 (311)

The role of NURR1 in metabolic abnormalities of Parkinson’s disease

Molecular Neurodegeneration, 2022
A constant metabolism and energy supply are crucial to all organs, particularly the brain. Age-dependent neurodegenerative diseases, such as Parkinson’s disease (PD), are associated with alterations in cellular metabolism.
Murad Al-Nusaif, Yuting Yang, Song Li, Cheng Cheng, Weidong Le   +4 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Neurological symptoms in infectious diseases

, 2019
Poleszak Julita, Szabat Przemysław, Szabat Marta, Wójcik Magdalena, Boreński Grzegorz, Milanowska Joanna. Neurological symptoms in infectious diseases. Journal of Education, Health and Sport. 2019;9(9):930-945. eISNN 2391-8306.
Wójcik, Magdalena, Szabat, Przemysław, Poleszak, Julita, Szabat, Marta, Boreński, Grzegorz, Milanowska, Joanna   +5 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Epigenetics in rare neurological diseases [PDF]

Rare neurological diseases include a vast group of heterogenous syndromes with primary impairment(s) in the peripheral and/or central nervous systems. Such rare disorders may have overlapping phenotypes, despite their distinct genetic etiology.
Mojgan Rastegar, Ashraf Kadar Shahib, Chris-Tiann Roberts, Khatereh Saei Arezoumand, James R. Davie   +4 more
core   +1 more source

Automated Vowel Articulation Analysis in Connected Speech Among Progressive Neurological Diseases, Dysarthria Types, and Dysarthria Severities.

, 2023
PURPOSE Although articulatory impairment represents distinct speech characteristics in most neurological diseases affecting movement, methods allowing automated assessments of articulation deficits from the connected speech are scarce.
Jan Rusz, Illner, Vojtech, Vojtech Illner, Dominik Skrabal, Skrabal, Dominik, Rusz, Jan, Jiri Klempir, Klempir, Jiri, Tereza Tykalova, Tykalova, Tereza   +9 more
core   +1 more source

STN Versus GPi Deep Brain Stimulation for Action and Rest Tremor in Parkinson’s Disease

Frontiers in Human Neuroscience, 2020
ObjectiveTo investigate the effects of subthalamic nucleus (STN) and globus pallidus internus (GPi), deep brain stimulation (DBS) on individual action tremor/postural tremor (AT) and rest tremor (RT) in Parkinson’s disease (PD).
Joshua K. Wong, Vyas T. Viswanathan, Kamilia S. Nozile-Firth, Robert S. Eisinger, Emma L. Leone, Anuj M. Desai, Kelly D. Foote, Adolfo Ramirez-Zamora, Michael S. Okun, Aparna Wagle Shukla   +9 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Neurological Diseases: Implications in Medical and Dental Practices

, 2019
Neurological and neurodegenerative diseases have a significant impact on a patient's functionality, independence, and overall quality of life. Multidisciplinary clinical care, coordination, and treatment modifications are key to increasing survival rates
Ariana, Armin
core  

Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells

Neurobiology of Disease, 2015
Heterozygous mutations in GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), are a major risk factor for sporadic Parkinson's disease (PD).
Giulia Ambrosi, Cristina Ghezzi, Roberta Zangaglia, Giovanna Levandis, Claudio Pacchetti, Fabio Blandini   +5 more
doaj   +1 more source