Results 81 to 90 of about 3,097,745 (309)

The potential roles of m6A modification in regulating the inflammatory response in microglia

Journal of Neuroinflammation, 2021
Background Microglia are key regulators of the inflammatory response in the brain. Adenosine in RNAs can be converted to m6A (N6-methyladenosine), which regulates RNA metabolism and functions as a key epitranscriptomic modification.
Qi Li, Shaohong Wen, Weizhen Ye, Shunying Zhao, Xiangrong Liu   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Changes in Length of Stay for Neurological Geriatric Diseases in Korea between 2003 and 2007

, 2011
Background and Purpose The elderly population and the prevalence of stroke, dementia, and Parkinson's disease are increasing rapidly in Korea. The aim of this study was to establish the length of stay (LOS) for neurological geriatric diseases, and ...
Im-Seok Koh, Bae, Hee-Joon, Koh, Im-Seok, Chang, Soung Hoon, Kim, Hyeong Su, Lee, Kun Sei, Hee-Joon Bae, Do-Hui Im, Soung Hoon Chang, Jae-Hyeok Heo, Hyeong Su Kim, Kun Sei Lee, Heo, Jae-Hyeok, Im, Do-Hui   +13 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Neurological Diseases: Implications in Medical and Dental Practices

, 2019
Neurological and neurodegenerative diseases have a significant impact on a patient's functionality, independence, and overall quality of life. Multidisciplinary clinical care, coordination, and treatment modifications are key to increasing survival rates
Ariana, Armin
core  

STN Versus GPi Deep Brain Stimulation for Action and Rest Tremor in Parkinson’s Disease

Frontiers in Human Neuroscience, 2020
ObjectiveTo investigate the effects of subthalamic nucleus (STN) and globus pallidus internus (GPi), deep brain stimulation (DBS) on individual action tremor/postural tremor (AT) and rest tremor (RT) in Parkinson’s disease (PD).
Joshua K. Wong, Vyas T. Viswanathan, Kamilia S. Nozile-Firth, Robert S. Eisinger, Emma L. Leone, Anuj M. Desai, Kelly D. Foote, Adolfo Ramirez-Zamora, Michael S. Okun, Aparna Wagle Shukla   +9 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Idebenone: Clinical Potential Beyond Neurological Diseases [PDF]

Bin Yi,1– 4,* Jun Zeng,1– 4,* Jiashuo Li,1– 4,* Kunfeng Liu,1– 4 Xiaocheng Zhu,4,5 Xiang Chen,4,5 Yang Gao1– 4 1Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ...
Li J, Liu K, Yi B, Zeng J, Gao Y, Zhu X, Chen X   +6 more
core  

The characteristics of autonomic nerve dysfunction and sympathetic skin response in patients with gout

Chinese Journal of Contemporary Neurology and Neurosurgery, 2019
Objective To analyze the clinical features of autonomic nerve dysfunction and sympathetic skin response (SSR) in patients with gout. Methods A total of 25 patients with gout diagnosed from March 2017 to January 2018 were enrolled, including 10 patients ...
Li SONG, Qiao⁃jun PENG, Yu⁃feng WANG, Yang LAN , Chao WU, Qing⁃rong OUYANG, Yu⁃feng QING , Xiao⁃ming WANG   +7 more
doaj   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source