Results 111 to 120 of about 10,652,159 (339)

Antioxidant Supplementation in the Treatment of Aging-Associated Diseases [PDF]

, 2016
Oxidative stress is generally considered as the consequence of an imbalance between pro- and antioxidants species, which often results into indiscriminate and global damage at the organismal level.
Conti, V, Corbi, G, De Lise, F, Di Donato, A, Filippelli, A, Izzo, V, Manzo, V, Russomanno, G   +7 more
core   +2 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Molecular Mechanism Involved in the Pathogenesis of Early-Onset Epileptic Encephalopathy [PDF]

, 2019
Recent studies have shown that neurologic inflammation may both precipitate and sustain seizures, suggesting that inflammation may be involved not only in epileptogenesis but also in determining the drug-resistant profile.
Corsello G, Falsaperla R, Marino S, Pavone P, Saporito MAN, Vitaliti G   +5 more
core   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Interleukin-17 in Chronic Inflammatory Neurological Diseases

Frontiers in Immunology, 2020
A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated in the pathogenesis of chronic inflammatory and autoimmune diseases.
J. Milovanović, A. Arsenijevic, B. Stojanovic, T. Kanjevac, Dragana Arsenijević, G. Radosavljević, M. Milovanovic, N. Arsenijević   +7 more
semanticscholar   +1 more source

Neurological complications of immune checkpoint inhibitors: what happens when you \u27take the brakes off\u27 the immune system. [PDF]

, 2018
Patients with advanced malignancies treated with immune checkpoint inhibitors are at increased risk for developing immune-related neurological complications.
Dalakas, Marinos
core   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Examination and diagnosis of electronic patient records and their associated ethics: a scoping literature review

BMC Medical Ethics, 2020
Background Electronic patient record (EPR) technology is a key enabler for improvements to healthcare service and management. To ensure these improvements and the means to achieve them are socially and ethically desirable, careful consideration of the ...
Tim Jacquemard, Colin P. Doherty, Mary B. Fitzsimons   +2 more
doaj   +1 more source

Association Between the Change of Coagulation Parameters and Clinical Prognosis in Acute Ischemic Stroke Patients After Intravenous Thrombolysis With rt-PA

Clinical and Applied Thrombosis/Hemostasis, 2021
Acute ischemic stroke patients with intravenous (IV) recombinant tissue plasminogen activator (rt-PA) thrombolysis have different outcomes. The degree of thrombolysis depends largely on the delicate balance of coagulation and fibrinolysis.
Yu Wang MD, Jia Zhang MD, Zhentang Cao MD, Qian Zhang MD, PhD, Xingquan Zhao MD, PhD   +4 more
doaj   +1 more source

Dysphagia in neurological diseases: a literature review

Neurological Sciences, 2020
Dysphagia is defined as an impairment of this complex and integrated sensorimotor system. It is estimated that 400,000 to 800,000 individuals worldwide develop neurogenic dysphagia per year.
Mariangela Panebianco, R. Marchese-Ragona, Stefano Masiero, D. A. Restivo   +3 more
semanticscholar   +1 more source