Results 41 to 50 of about 527,553 (336)

Targeting foam cell formation in inflammatory brain diseases by the histone modifier MS‐275

open access: yesAnnals of Clinical and Translational Neurology, 2020
Objective To assess class I‐histone deacetylase (HDAC) inhibition on formation of lipid‐accumulating, disease‐promoting phagocytes upon myelin load in vitro, relevant for neuroinflammatory disorders like multiple sclerosis (MS) and cerebral X‐linked ...
Bettina Zierfuss   +11 more
doaj   +1 more source

A History of Dystonia: Ancient to Modern [PDF]

open access: yes, 2017
Before 1911, when Hermann Oppenheim introduced the term dystonia, this movement disorder lacked a unifying descriptor. While words like epilepsy, apoplexy, and palsy have had their meanings since antiquity, references to dystonia are much harder to ...
Deborah Thorpe   +3 more
core   +1 more source

Apoptosis in development and disease of the nervous system: II. Apoptosis in childhood neurologic disease

open access: yesPediatric Neurology, 1997
The loss of cells in the human nervous system has long been known as the hallmark of incurable degenerative disease. Recent studies that began with attempts to understand cell loss during normal development have now begun to contribute to our understanding of the process of pathological cell loss.
H A, Gelbard, R M, Boustany, N F, Schor
openaire   +2 more sources

Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders. [PDF]

open access: yes, 2019
Purpose of reviewThe aim of this study was to examine the synaptic biomarker neurogranin in cerebrospinal fluid (CSF) in different stages of HIV infection and in relation to what is known about CSF neurogranin in other neurodegenerative diseases.Recent ...
Blennow, Kaj   +6 more
core   +2 more sources

Repopulation of microglia and its implications for CNS disorders: Insights from the single-cell era

open access: yesNeurobiology of Disease
Microglia, as resident macrophages in the central nervous system (CNS), have been the focus of the scientific community. The pace of exploration in the origin and development of microglia, though tortuous, never stops.
Cong Chen   +6 more
doaj   +1 more source

Diagnostic value of exosomal miR-1246 for Parkinson’s disease [PDF]

open access: yesXin yixue
Objective To investigate the diagnostic value of exosomal miR-1246 for Parkinson’s disease (PD). Methods Serum samples were collected from 30 PD patients (PD group) and 30 healthy controls (control group) receiving physical examination in the Second ...
WANG Xiaobei, YANG Shan, LI Yatan, YANG Xinling
doaj   +1 more source

Study on differential gene expression profile of serum exosomes in patients with acute cerebral infarction

open access: yesDigital Chinese Medicine, 2021
Objective: To analyze the differential gene expression profile of serum exosomes in patients with acute cerebral infarction (ACI) and clarify the changes in gene expression related to cerebral infarction injury and the potential serum markers.
Tang Rongmei   +4 more
doaj   +1 more source

Neurology in the 21st century: contemporary state of diagnostics and therapeutics [PDF]

open access: yes, 2004
Although neurological disease has been recognized since antiquity, neurology as a systematic clinical discipline is less than 130 years old. Neurological practice has traditionally been constrained by the complexity of the human nervous system, which has
Shafqat, Saad, Wasay, Mohammad
core   +1 more source

Central nervous system neuronal surface antibody associated syndromes: review and guidelines for recognition

open access: yesJournal of Neurology Neurosurgery & Psychiatry, 2012
The concept of antibody mediated CNS disorders is relatively recent. The classical CNS paraneoplastic neurological syndromes are thought to be T cell mediated, and the onconeural antibodies merely biomarkers for the presence of the tumour.
L. Zuliani   +4 more
semanticscholar   +1 more source

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