Results 41 to 50 of about 93,066 (306)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Neuromuscular Blocking Agents

Journal of Pharmacy and Pharmacology, 1959
Abstract NSN- and NNN-Tris-onium compounds related to dihexasulphonium and dihexazonium in which N-alkyl substituents are varied have been synthesised. All compounds tested qualitatively resembled tubocurarine in their action. Stepwise replacement of Et by Me in dihexasulphonium tri-ethiodide decreases potency and some C 10-like effects ...
Fiona Macleod Carey, D Edwards, J J Lewis, J B Stenlake   +3 more
openaire   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats

Nature Communications
Neuromuscular blocking agents are used commonly to induce skeletal muscle relaxation during surgery. While muscle relaxation facilitates surgical procedures and tracheal intubation, adequate recovery of muscle function after surgery is required to ...
Marianne Skals, Martin Broch-Lips, Martin Brandhøj Skov, Anders Riisager, Judith Ceelen, Ole Bækgaard Nielsen, Sorin J. Brull, Hans D. de Boer, Thomas Holm Pedersen   +8 more
doaj   +1 more source

Neuromuscular Weakness and Paralysis Produced by Snakebite Envenoming: Mechanisms and Proposed Standards for Clinical Assessment

Toxins, 2023
Respiratory and airway-protective muscle weakness caused by the blockade of neuromuscular transmission is a major cause of early mortality from snakebite envenoming (SBE).
Philip E. Bickler, Michael Abouyannis, Ashish Bhalla, Matthew R. Lewin   +3 more
doaj   +1 more source

Perioperative and anesthetic deaths: toxicological and medico legal aspects [PDF]

, 2019
Background: Anesthesia has become safer during decades, though there is still a preventable mortality; the complexity of medical and surgical interventions, increasingly older and sicker patients, has created a host of new hazards in anesthesiology.
Argo A., Buscemi R., Karch S. B., Lanzarone A., Roccuzzo R., Zerbo S.   +5 more
core   +1 more source

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Neuromuscular blockade management for intraoperative neural monitoring

Kaohsiung Journal of Medical Sciences, 2020
This article reviews the literature on development of neuromuscular blockade management in thyroid surgery with intraoperative neural monitoring (IONM) in the past decade.
I‐Cheng Lu, Sheng‐Hua Wu, Che‐Wei Wu   +2 more
doaj   +1 more source

Monitorering og reversering av nevromuskulær blokade ved generell anestesi – en tverrsnittsundersøkelse av anestesipersonells praksis og vurderinger

Inspira, 2023
Bakgrunn: Bruk av nevromuskulær blokade er en integrert del av dagens anestesipraksis, og risiko for restcurarisering er til stede. Dette kan medføre postoperative lungekomplikasjoner.
Sigrunn Drageset, Pål André Hegland, Vilde Rødland, Ina Dahl, Gro Hovland   +4 more
doaj   +1 more source

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]

, 2018
Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi, Broad, John, Carroll, Rebecca, Chin-Aleong, Joanne, Darreh-Shori, Taher, Elahi, Shezan, Karami, Azadeh, Knowles, Charles H., Kung, Victor W. S., Martin, Joanne E., Palmer, Alexandra, Saffrey, M. Jill, Sanger, Gareth John, Thaha, Mohamed Adhnan   +13 more
core   +2 more sources