Results 51 to 60 of about 46,257 (309)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study

Revista Brasileira de Anestesiologia, 2015
BACKGROUND AND OBJECTIVES: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental ...
Angélica de Fátima Braga, Vanessa Henriques Carvalho, Franklin Sarmento Braga, Gloria Maria Braga Potério, Filipe Nadir Caparica Santos   +4 more
doaj   +1 more source

Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries [PDF]

, 2016
IMPORTANCE: Limited information exists about the epidemiology, recognition, management, and outcomes of patients with the acute respiratory distress syndrome (ARDS).
Alejandro, Risso V., Alvarez, Javier, Bellani, Giacomo, Bettini, Lisandro R., Bisso, Mariano Carboni, Brochard, Laurent, Cani, Alma, Cardonnet, Luis P., Chena, Ariel, Conti, Sara, Daldin, Julio, Dellera, Christian, Esteban, Andres, Estenssoro, Elisa, Fan, Eddy, Fernandez, Ruben O., Francois, Guy M., Gattinoni, Luciano, Grubissich, Nicolas, Ilutovich, Santiago, Insaurralde, Carolina S., Laffey, John G., Larsson, Anders, Lovazzano, Pablo, Madotto, Fabiana, McAuley, Daniel F., Nunci, Lordian, Osman, Emilio M., Pellegrini, Carlos A., Pesenti, Antonio, Pham, Tài, Plotnikow, Gustavo A., Pozo, Norberto C., Rabboni, Francesca, Ranieri, Marco, Rubenfeld, Gordon, Saenz, María G., Schultz, Marcus J., Setten, Mariano G., Simonis, Fabienne D., Slutsky, Arthur S., Sula, Hektor, Thompson, B. Taylor, Tiribelli, Norberto, van Haren, Frank, Vasquez, Daniela N., Villar, Veronica, Vinzio, Mauricio, Wrigge, Hermann, Zazu, Alan   +49 more
core   +3 more sources

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

Role of amino acid infusion in delayed recovery from neuromuscular blockers

Indian Journal of Anaesthesia, 2010
This case report highlights the anaesthetic management of a patient who had residual muscle paralysis following neuromuscular blockade, which was attributed to hypothermia and corrected by administration of amino acid solution.
Seema Kalra, Rachna Wadhwa
doaj   +1 more source

Tracheal intubation without neuromuscular blocking drugs in children [PDF]

, 2009
No abstract ...
Aantaa, Abdallah, Aouad, Batra, Blair, Blair, Bode, Crawford, De Fatima De Assuncao Braga, Drenger, Duman, Gupta, Hansen, Hansen, Helbo-Hansen, Hiller, Humphries, Inomata, Inomata, Inomata, Inomata, Inomata, Klemola, Lerman, Meakin, Mertes, Min, Morgan, Nishina, O’Brien, Politis, Politis, Robinson, Senel, Simon, Splinter, Steyn, Swan, Taguchi, Thwaites, Wappler, Warner, Watcha, Watcha, Watcha, Watcha, Weber, Woods, Xue, Xue, Xue, Xue, Yaguchi   +52 more
core   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Convulsant actions of 4-aminopyridine on the guinea-pig olfactory cortex slice [PDF]

, 1982
The effects of bath-applied 4-aminopyridine on neurones and extracellular potassium and calcium concentrations were recorded in slices of guinea-pig olfactory cortex. Neurones were orthodromically activated by stimulating the lateral olfactory tract.
Baranyi, Ben-Ari, Brismar, Brown, Buckle, Collins, Constanti, DiFrancesco, Dingemanse, Galvan, Galvan, Galvan, Gerrit Ten Bruggencate, Gilbey, Golenhofen, Halliwell, Heinemann, Jankowska, Jefferys, Kocsis, Lemeignan, Lipicky, Llinaś, Lundh, Martin Galvan, Matthews, McAfee, Mori, Neuman, Nicholson, Nicoll, Pelhate, Peter Grafe, Pichon, Scholfield, Scholfield, Schwartzkroin, Schwartzkroin, Sherratt, Shimahara, Spyker, Szente, Thesleff, Thompson, Ulbricht, von Haxthausen, Yanagisawa, Yeh   +47 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Effects of dexamethasone and hydrocortisone on rocuroniuminduced neuromuscular blockade and reversal by sugammadex in phrenic nerve-hemidiaphragm rat model [PDF]

Korean Journal of Anesthesiology, 2019
Background The facilitator effects of steroids on neuromuscular transmission may cause resistance to neuromuscular blocking agents. Additionally, steroids may hinder sugammadex reversal of neuromuscular blockade, but these findings remain controversial ...
Heyran Choi, Sun Young Park, Yong Beom Kim, Junyong In, Hong Seuk Yang, Jeong-seok Lee, Sanghyun Kim, Suyeon Park   +7 more
doaj   +1 more source