Results 61 to 70 of about 362,451 (418)

Preclinical common data elements for general pharmacological studies (pharmacokinetic sample collection, tolerability, and drug administration). A report of the TASK3‐WG1A General Pharmacology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2023
Abstract Growing concerns over rigor and reproducibility of preclinical studies, including consistency across laboratories and translation to clinical populations, have triggered efforts to harmonize methodologies. This includes the first set of preclinical common data elements (CDEs) for epilepsy research studies, as well as Case Report Forms (CRFs ...
Lisa Coles, Patrick A. Forcelli, Karine Leclercq, Anna‐Maria Katsarou, Brian D. Klein, Heidrun Potschka, Rudiger Koehling, Lauren Harte‐Hargrove, Aristea S. Galanopoulou, Cameron S. Metcalf   +9 more
wiley   +1 more source

Sugammadex, the Guardian of Deep Muscle Relaxation During Conventional and Robot-Assisted Laparoscopic Surgery: A Narrative Review

Drug Design, Development and Therapy, 2021
Yan Sun,* Zhilin Wu,* Qi Wang,* Rui Chen, Shujun Sun, Yun Lin Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China*These authors ...
Sun Y, Wu Z, Wang Q, Chen R, Sun S, Lin Y   +5 more
doaj  

Perioperative and anesthetic deaths: toxicological and medico legal aspects [PDF]

, 2019
Background: Anesthesia has become safer during decades, though there is still a preventable mortality; the complexity of medical and surgical interventions, increasingly older and sicker patients, has created a host of new hazards in anesthesiology.
Argo A., Buscemi R., Karch S. B., Lanzarone A., Roccuzzo R., Zerbo S.   +5 more
core   +1 more source

On the validation of Newcomb-Benford law and Weibull distribution in neuromuscular transmission [PDF]

, 2020
The neuromuscular junction represents a relevant substrate for revealing important biophysical mechanisms of synaptic transmission. In this context, calcium ions are important in the synapse machinery, providing the nervous impulse transmission to the muscle fiber.
arxiv   +1 more source

Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study

Revista Brasileira de Anestesiologia, 2015
BACKGROUND AND OBJECTIVES: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental ...
Angélica de Fátima Braga, Vanessa Henriques Carvalho, Franklin Sarmento Braga, Gloria Maria Braga Potério, Filipe Nadir Caparica Santos   +4 more
doaj   +1 more source

Influence of different local anesthetics on atracurium neuromuscular blockade on rats [PDF]

Revista Brasileira de Anestesiologia, 2020
Introduction: The association between local anesthetics (LA) and neuromuscular blocking (NMB) drugs in clinical practice, and the possibility of interaction between these drugs has been investigated.
João Paulo Soares da Silva Trizotti, Angélica de Fátima de Assunção Braga, Vanessa Henriques Carvalho, Franklin Sarmento da Silva Braga   +3 more
doaj   +3 more sources

Neostigmine Versus Sugammadex for Reversal of Neuromuscular Blockade and Effects on Reintubation for Respiratory Failure or Newly Initiated Noninvasive Ventilation: An Interrupted Time Series Design

Anesthesia and Analgesia, 2019
BACKGROUND: Pulmonary complications related to residual neuromuscular blockade lead to morbidity and mortality. Using an interrupted time series design, we tested whether proportions of reintubation for respiratory failure or new noninvasive ventilation ...
Martin Krause, Shannon K. McWilliams, Kenneth Bullard, Lena M. Mayes, L. Jameson, S. Mikulich-Gilbertson, A. Fernandez-Bustamante, K. Bartels   +7 more
semanticscholar   +1 more source

Ca2+-activated K+ channels modulate microglia affecting motor neuron survivalin hSOD1G93A mice [PDF]

, 2018
Recent studies described a critical role for microglia in amyotrophic lateral sclerosis (ALS), where these CNS-resident immune cells participate in the establishment of an inflammatory microenvironment that contributes to motor neuron degeneration ...
Antonangeli, Fabrizio, Carbonari, Laura, Cocozza, Germana, D'Alessandro, Giuseppina, di Castro, Maria Amalia, Garofalo, Stefano, Grassi, Francesca, Grimaldi, Alfonso, Limatola, Cristina, Madonna, Michele, Mainiero, Fabrizio, Porzia, Alessandra, Santoni, Angela, Wulff, Heike   +13 more
core   +2 more sources

Effects of dexamethasone and hydrocortisone on rocuroniuminduced neuromuscular blockade and reversal by sugammadex in phrenic nerve-hemidiaphragm rat model [PDF]

Korean Journal of Anesthesiology, 2019
Background The facilitator effects of steroids on neuromuscular transmission may cause resistance to neuromuscular blocking agents. Additionally, steroids may hinder sugammadex reversal of neuromuscular blockade, but these findings remain controversial ...
Heyran Choi, Sun Young Park, Yong Beom Kim, Junyong In, Hong Seuk Yang, Jeong-seok Lee, Sanghyun Kim, Suyeon Park   +7 more
doaj   +1 more source

A comparison of a prototype electromyograph vs. a mechanomyograph and an acceleromyograph for assessment of neuromuscular blockade†

Anaesthesia, 2019
The extent of neuromuscular blockade during anaesthesia is frequently measured using a train‐of‐four stimulus. Various monitors have been used to quantify the train‐of‐four, including mechanomyography, acceleromyography and electromyography ...
A. Bowdle, L. Bussey, K. Michaelsen, S. Jelacic, B. Nair, K. Togashi, J. Hulvershorn   +6 more
semanticscholar   +1 more source