Results 151 to 160 of about 160,936 (251)

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications

Muscle &Nerve, EarlyView.
ABSTRACT Peripheral nerve injuries (PNIs) are a common cause of long‐term motor and sensory disability despite advances in microsurgical repair. Functional recovery following PNI depends not only on axonal regeneration, but also on preservation of distal nerve pathways, maintenance of neuromuscular junction integrity, prevention of irreversible muscle ...
Sarah M. Smith, Kirsten M. Schlosser, Ranee Munaim, Stephanie H. Vu, JulieAnn H. Uh, Yusha K. Liu   +5 more
wiley   +1 more source

Enabling Functional Independence: A Scoping Review of Upper Extremity Assistive Devices for Adults With Progressive Neuromuscular Diseases

Muscle &Nerve, EarlyView.
This scoping review summarizes the spectrum of upper extremity assistive devices for adults with progressive neuromuscular diseases, ranging from low‐tech supports to advanced robotics, exoskeletons, and brain‐computer interface systems. While these technologies show promise for improving enabling function, current evidence is largely limited to ...
Katherine M. Burke, Stephanie Johnson, Kayla Chomko, Angela Escalante, Kendall C. Hall, Melis Lydston, Courtney Uek, Gabriella Casagrande, Hyun Jung Kim, James Arnold, David Pont‐Esteban, Harrison Young, Conor Walsh, Sabrina Paganoni   +13 more
wiley   +1 more source

Sociodemographic and Clinical Profile of Adult Males With Duchenne Muscular Dystrophy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Due to improvements in clinical care, individuals with Duchenne muscular dystrophy (DMD) are living into adulthood, but little has been published about adults with DMD. We describe key characteristics of adults with DMD using US population‐based surveillance data.
Manju Jayasimha Pula Jayaram, Hollie A. Clark, Natalie Street, Yining Yang, Shannon Kilburn, Shiny Thomas, Christina Westfield, Katherine D. Mathews, Emma Ciafaloni, Aida Soim, Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet)   +12 more
wiley   +1 more source

Assessment of Lectin Staining Biomarkers for GNE Myopathy Gene Therapy

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims GNE myopathy (GNEM) is a rare, autosomal recessive disorder caused by mutations in the UDP‐N‐acetylglucosamine (GlcNAc) 2‐epimerase/N‐acetylmannosamine (ManNAc) kinase (GNE) gene, which encodes a required enzyme for sialic acid (SA) biosynthesis.
Kristina M. Sattler, Brian J. Paleo, Mackenzie N. Roth, Kara E. Bradley, Megan N. Winkler, Wakako Yoshioka, Ichizo Nishino, Christoph Lepper, Kelly E. Crowe   +8 more
wiley   +1 more source

How Can We Personalize the Delivery of Onabotulinumtoxin‐A for Patients With Neurogenic Lower Urinary Tract Dysfunction?

Neurourology and Urodynamics, EarlyView.
ABSTRACT Background & Aims Neurogenic lower urinary tract dysfunction (NLUTD) can produce bothersome urinary symptoms, impact quality of life, and in some cases, lead to deterioration of upper urinary tract function. Intradetrusor injection of onabotulinumtoxin‐A (BoNT‐A) is approved for NLUTD in patients who have an inadequate response to or ...
Shirley L. Wang, William I. Jaffe, Ariana L. Smith   +2 more
wiley   +1 more source

Neuromuscular disorders of infancy, childhood, and adolescence : a clinician's approach /

Neuromuscular disorders are diagnosed across the lifespan and create many challenges especially with infants, children and adolescents. This new edition of the definitive reference, edited by the established world renowned authorities on the science ...
Ryan, Monique M.,editor., De Vivo, Darryl C.,editor., Jones, H. Roydeneditor., Darras, Basil T.,editor.   +3 more
core  

Feasibility and Exploratory Outcomes of Foot‐Ankle and Walking Exercises for Diabetic Neuropathy, Stress, and Quality of Life: A Pilot Randomized Controlled Trial

Research in Nursing &Health, EarlyView.
ABSTRACT Foot–ankle and walking exercises have been proposed as potential strategies for managing symptoms in people with diabetic peripheral neuropathy (DPN), yet evidence from primary care remains limited. This pilot study assessed the feasibility and acceptability of these interventions and explored preliminary outcome patterns in DPN, stress, and ...
Siti Fadlilah, Wahyu Rochdiat Murdhiono, Ariyanto Nugroho, Yohanes Andy Rias, Shih Hsin Hsiao, Kai Ling Lee, Po Hao Feng, Hsiu Ting Tsai   +7 more
wiley   +1 more source

Continuous Respiratory Oscillometry in Pediatric Laparoscopic Surgery—The COMET Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Laparoscopic appendectomy is the accepted surgical approach for appendicitis in centers worldwide. Laparoscopic surgery requires the creation of a pneumoperitoneum to facilitate surgical access. Laparoscopic surgery affects the respiratory mechanics of patients under general anesthesia.
Neil Hauser, Emanuela Zannin, Julie Nguyen, Anwen Taplin, Sara Vigevani, David Sommerfield, Raffaele Dellaca, R. Nazim Khan, Aine Sommerfield, Britta S. von Ungern‐Sternberg   +9 more
wiley   +1 more source

Botulinum toxin use in patients with neurological disorders: A U.S.‐based claims database analysis

PM&R, EarlyView.
Abstract Background and Objective Real‐world evidence describing long‐term persistency with botulinum toxin (BoNT) therapy is limited. We assessed treatment patterns and persistency with BoNT in clinical practice over 2 years. Design Retrospective, longitudinal, claims database analysis. Setting Medical claims data from the Merative MarketScan database
David M. Simpson, Jonathan Bouchard, Simon Page, Seth Goldfarb, Atul T. Patel   +4 more
wiley   +1 more source