Results 91 to 100 of about 18,093 (237)

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Neuromuscular blocking agents and intubation [PDF]

Anaesthesia, 2018
M, Sorbello, S, Falcetta, I, Di Giacinto, R, Cataldo   +3 more
openaire   +2 more sources

Three‐Dimensional Assessment of Upper Airway Morphology and Sleep‐Disordered Breathing Risk in Unilateral Craniofacial Microsomia: A Pilot Study

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objective Unilateral craniofacial microsomia (UCM) presents varying unilateral deficiencies of the temporomandibular joint, mandibular ramus, masticatory muscles, and adjacent soft tissues and ear. Reduced mandibular and maxillary dimensions may decrease upper airway volume and may increase the risk of sleep‐disordered breathing (SDB).
Akila Aiyar, Peter Stoustrup, Thomas Klit Pedersen, Xiaowen Niu   +3 more
wiley   +1 more source

Neuromuscular Blocking Agents and Reversal Agents Usage, and Neuromuscular Blockade Monitoring in the Intensive Care Unit – Review Article

International Journal of General Medicine
Maciej Szewczyk,1 Aleksandra Bieniecka,2 Kamil Sobolewski,3,4 Łukasz Banasiak,5 Łukasz Grabarczyk6 1Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology with the Department of ...
Szewczyk M, Bieniecka A, Sobolewski K, Banasiak Ł, Grabarczyk Ł   +4 more
doaj  

Breaking the Debilitating Cycle: Pathophysiology, Assessment, and Multimodal Intervention of Secondary Debilitation After Hip Fracture in Older Adults—A Narrative Review

Orthopaedic Surgery, EarlyView.
This article provides a comprehensive overview of the pathophysiological mechanisms underlying “secondary debilitation after hip fracture,” discusses the clinical application of risk assessment tools, and presents a phased, stepwise intervention strategy aimed at interrupting the “vicious cycle.” ABSTRACT Hip fractures pose a serious threat to the ...
Wenyang Xu, Fan Xu, Maoqiang Fan, Yao Liu, Zhe Song   +4 more
wiley   +1 more source

First Experience With Extravascular Implantable Cardioverter‐Defibrillator Under Deep Sedation

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background The Extravascular Implantable Cardioverter‐Defibrillator (EV‐ICD) utilizes a substernal lead to provide defibrillation and anti‐tachycardia pacing (ATP) while avoiding transvenous complications. General anesthesia (GA) was applied for implantation procedures in the EV‐ICD pivotal trial and is currently recommended by the ...
Nibras Soubh, Bernhard C. Danner, Ulrich Krause, Matthias J. Müller, Markus Zabel, Gerd Hasenfuß, Constanze Schmidt, Helge Haarmann, Eva Rasenack, Leonard Bergau   +9 more
wiley   +1 more source

Aktuelni problemi u primeni mišićnih relaksanata u kliničkoj praksi [PDF]

Vojnosanitetski Pregled, 2003
Konstantinović Slavko, Balkanov Trajan
doaj   +1 more source

Vision outcomes in dogs with primary glaucoma surgically treated with lensectomy and endolaser cyclophotocoagulation after an Ahmed valve gonioimplantation failure

Veterinary Ophthalmology, Volume 28, Issue 2, Page 207-217, March 2025.
Abstract Objective The aim of this study was to retrospectively evaluate vision outcomes of dogs with primary angle closure glaucoma (PACG) that underwent Ahmed valve gonioimplantation (AVG) followed by lensectomy and endolaser cyclophotocoagulation (ECP) with or without bleb resection after AVG failure.
Bactelius Turicea, Christian L. Munevar, Sydney G. Edwards, Lana L. Linton   +3 more
wiley   +1 more source

Translaryngeal Anesthesia and Deep Sedation for Dilation of Tracheal Stenosis with Rigid Bronchoscope in a Burn Patient

Advanced Biomedical Research
Tracheal stenosis may follow a period of tracheal intubation. Postintubation tracheal stenosis is caused by either cuff-induced ischemic damage, injury after formation of a tracheostomy, or a combination of the two.
Mir Mousa Aghdashi, Shahram Shokohi
doaj   +1 more source