Results 121 to 130 of about 18,093 (237)

New Insights Into Immunomodulatory Strategies for Drug Hypersensitivity Reactions: An EAACI Task Force Report

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT Drug hypersensitivity reactions (DHRs) are a global health concern and remain challenging to investigate owing to the heterogeneity of endotypes and phenotypes, as well as the lack of standardized biomarkers. Until recently, strict drug avoidance was the only management strategy for severe DHRs.
Ana Maria Copaescu, Valentina Gueli, Jitesh Chahuan, Waad Albalawi, Giovanna Sfriso, Mattia Giovannini, Leticia de las Vecillas, Aspasia Karavelia, Marina Labella, Ruben Fernandez‐Santamaria, Francesca Mori, Lene H. Garvey, Patrizia Bonadonna, Maria Jose Torres   +13 more
wiley   +1 more source

Effective dose of remimazolam co-administered with remifentanil to facilitate I-gel insertion without neuromuscular blocking agents: an up-and-down sequential allocation trial. [PDF]

BMC Anesthesiol, 2023
Oh J, Park SY, Lee GY, Park JH, Joe HB.
europepmc   +1 more source

Comparative Neuroanatomy of Hydrothermal Vent Shrimps: Ecological Differentiation Among Four Alvinocaridid Species

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
Hydrothermal vent shrimps share a conserved brain architecture with enlarged mushroom bodies and terminal medullae, shaped by similar environmental pressures. Despite this similarity, some anatomical features near the brain vary between species, suggesting that some ecological factors, such as microhabitat and trophic strategies, also influence nervous
Adrien Mathou, Julia Machon, Rebecca Meth, Magali Zbinden, Juliette Ravaux, Steffen Harzsch   +5 more
wiley   +1 more source

Cholesterol Drives IFITM3+ Microglia Activation and Induces STING Mediated Neuroinflammation After Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
After ischemic stroke, cholesterol accumulation in microglia is accompanied by the emergence of a pro‐inflammatory IFITM3+ subset with aberrant esterification and lipid droplet buildup. This metabolic stress is linked to mitochondrial dysfunction, STING activation, sustained neuroinflammation, and white matter injury.
Yue Cheng, Yuxi Zhou, Yonghui Chen, Tianni Shen, Yan Li, Chen Chen, Qiuyue Fan, Jie Qi, Peiying Li, Yueman Zhang   +9 more
wiley   +1 more source

Narrative Review of the Role of Nondepolarizing Neuromuscular Blocking Agents in Anesthesia: Perspective 2026. [PDF]

Med Sci Monit
Radkowski P, Rafałowicz A, Wojciechowka UJ, Muża M, Marczuk K, Mamala M, Grabarczyk Ł.   +6 more
europepmc   +1 more source

Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones. [PDF]

Front Immunol, 2021
Elst J, Maurer M, Sabato V, Faber MA, Bridts CH, Mertens C, Van Houdt M, Van Gasse AL, van der Poorten MM, De Puysseleyr LP, Hagendorens MM, Van Tendeloo VF, Lion E, Campillo-Davo D, Ebo DG.   +14 more
europepmc   +1 more source

Recombinant Artemin‐Fc Fusion Protein Attenuates TLR4/NF‐κB‐Associated Neuroinflammation and Modulates Inhibitory/Excitatory Synaptic Marker Expression After Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Intrathecal ARTN‐Fc treatment attenuates TLR4/NF‐κB‐associated neuroinflammation, promotes microglia/macrophage polarization towards an anti‐inflammatory phenotype, and improves functional recovery after spinal cord injury. ARTN‐Fc also modulates inhibitory/excitatory synaptic marker expression in the L4–L5 spinal dorsal horn, which may contribute to ...
Wenjie Lu, Yurong Tu, Renkai Wang, Minghao Jiang, Junyu Zhuang, Jiahui Song, Ping Wu, Sunren Sheng, Sipin Zhu, Zhouguang Wang   +9 more
wiley   +1 more source

Neuromuscular Blocking Agents in Anesthesia: A Narrative Review of Contemporary Challenges and Reversal Approaches. [PDF]

J Clin Med
Radkowski P, Jutrzenka M, Szewczyk M, Witkowska A, Muża M, Onichimowski D, Grabarczyk Ł.   +6 more
europepmc   +1 more source

Multifaceted Roles of Chloroquines in Gastrointestinal Disorders and Beyond

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Chloroquine (CQ) and hydroxychloroquine (HCQ) modulate lysosomal activity and autophagy, suppressing gastrointestinal inflammation and reshaping pathogenic microbiota. These mechanisms alleviate inflammatory bowel disease, inhibit associated tumor growth, and provide benefits in certain autoimmune and viral conditions.
Sihyun Jeong, Eunsoo Kim, Yong Sung Kim, Eunok Im   +3 more
wiley   +1 more source

Use of Neuromuscular Blocking Agents in Elderly Patients: A Narrative Review in Geriatric Medicine. [PDF]

Int J Gen Med
Radkowski P, Szewczyk M, Dabdoub T, Murthy R, Grabarczyk Ł.   +4 more
europepmc   +1 more source