Results 161 to 170 of about 3,526 (188)
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THE MECHANISMS UNDERLYING NEUROMUSCULAR BLOCK FOLLOWING PROLONGED EXPOSURE TO DEPOLARIZING AGENTS
Annals of the New York Academy of Sciences, 1966W L Nastuk
exaly +3 more sources
Two new short-acting non-depolarizing neuromuscular blocking agents
Experientia, 1972Le chlorure de 1,1′-octamethylene et le methylsulfate de 5,5′-octamethylenebis ont chez le chat un effet de blocage neuro-musculaire non depolarisant, de courte duree. Les comparaisons faites avec des analogues voisins suggerent que l'activite de ces composes est influencee par le degre d'empechement sterique autour des atomes d'azote quaternaire.
F C, Copp +4 more
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Clinical pharmacology of ORG 7617, a short-acting non-depolarizing neuromuscular blocking agent
European Journal of Clinical Pharmacology, 1994The dose-response relationship and the time course of action of Org 7617, a short acting non-depolarizing neuromuscular blocking agent, were evaluated during thiopentone, fentanyl, halothane and N2O anaesthesia. Neuromuscular transmission was monitored mechanomyographically. The ED50 and ED90 were calculated after single bolus doses of the drug. Twelve,
van den Broek, L +4 more
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Acta Anaesthesiologica Scandinavica, 1984
The effect of lignocaine on the depolarization and contracture responses produced by acetylcholine (ACh) or tetraethylammonium (TEA) was studied in the isolated chick biventer cervicis (BVC) nerve‐muscle preparation using the moving fluid electrode technique.
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The effect of lignocaine on the depolarization and contracture responses produced by acetylcholine (ACh) or tetraethylammonium (TEA) was studied in the isolated chick biventer cervicis (BVC) nerve‐muscle preparation using the moving fluid electrode technique.
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Acta Anaesthesiologica Scandinavica, 1980
We describe the clinical use, for intubation purposes, of Org‐NC45, a new non‐depolarizing neuromuscular blocking agent. Administration of 50 and 72 μg/kg of this drug allowed good to excellent endotracheal intubation conditions within 3 and 2 min, respectively. In none of the cases was a signifcant change in blood pressure or heart rate seen after the
N, Krieg +3 more
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We describe the clinical use, for intubation purposes, of Org‐NC45, a new non‐depolarizing neuromuscular blocking agent. Administration of 50 and 72 μg/kg of this drug allowed good to excellent endotracheal intubation conditions within 3 and 2 min, respectively. In none of the cases was a signifcant change in blood pressure or heart rate seen after the
N, Krieg +3 more
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Combining non-depolarizing neuromuscular blocking agents: synergism, addition or antagonism?
Current Opinion in Anaesthesiology, 1999As the quality of currently available relaxants has improved, the need to combine relaxants to minimize the incidence and severity of their side-effects has decreased. Little work has been done in the past year characterizing the effects of combining different non-depolarizing neuromuscular blocking agents.
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General Pharmacology: The Vascular System, 1999
Pancuronium, vecuronium, and rocuronium produce different cardiac effects. Using spontaneously beating right and electrically stimulated left rat atria, while measuring developed force, effective refractory period, and heart rate, we determined and compared the concentration-dependent cardiac effects of the compounds.
A L, Melnikov +3 more
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Pancuronium, vecuronium, and rocuronium produce different cardiac effects. Using spontaneously beating right and electrically stimulated left rat atria, while measuring developed force, effective refractory period, and heart rate, we determined and compared the concentration-dependent cardiac effects of the compounds.
A L, Melnikov +3 more
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An analytical pharmacodynamic model for nondepolarizing neuromuscular blocking agents
Journal of Pharmacokinetics and Biopharmaceutics, 1981A pharmacodynamic model for nondepolarizing neuromuscular blocking agents (NMBA) is developed and tested with different sets of data (NMBA plasma concentration and time evolution of muscular paralysis). This model takes into account the binding of NMBA to the cholinergic motor endplate receptors and thus permits estimation of the apparent equilibrium ...
D'Hollander, Alain, Delcroix, Claude
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Arzneimittel-Forschung, 1982
The pharmacokinetics of 2 beta, 16 beta-bis-(4'-dimethyl-1'-piperazino)-3 alpha, 17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, Arduan), a new non-depolarizing neuromuscular blocking agent, was studied in surgical patients. Plasma concentration-time curves of pipecurium bromide were evaluated by fitting the data to a bi-exponential
E, Tassonyi, G, Szabó, L, Vereczkey
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The pharmacokinetics of 2 beta, 16 beta-bis-(4'-dimethyl-1'-piperazino)-3 alpha, 17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, Arduan), a new non-depolarizing neuromuscular blocking agent, was studied in surgical patients. Plasma concentration-time curves of pipecurium bromide were evaluated by fitting the data to a bi-exponential
E, Tassonyi, G, Szabó, L, Vereczkey
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Acta anaesthesiologica Sinica, 1998
Rocuronium is a new nondepolarizing muscle relaxant. It features a rapid onset and lack of histamine release: It has an intermediate onset of action as vecuronium. The purpose of this study was to compare the neuromuscular action and condition of intubation after a bolus dose of rocuronium or vecuronium (2 x ED90).
P L, Lin +5 more
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Rocuronium is a new nondepolarizing muscle relaxant. It features a rapid onset and lack of histamine release: It has an intermediate onset of action as vecuronium. The purpose of this study was to compare the neuromuscular action and condition of intubation after a bolus dose of rocuronium or vecuronium (2 x ED90).
P L, Lin +5 more
openaire +1 more source