Current clinical application of dantrolene sodium [PDF]
Anesthesia and Pain Medicine, 2023 Dantrolene sodium (DS) was first introduced as an oral antispasmodic drug. However, in 1975, DS was demonstrated to be effective for managing malignant hyperthermia (MH) and was adopted as the primary therapeutic drug after intravenous administration ...
Hong Seuk Yang +5 more
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Comparison of the neuromuscular effects of two infusion rates of rocuronium in anesthetized pigs
Acta Veterinaria Scandinavica, 2022 Background: Neuromuscular blocking agents are frequently administered to pigs used for research. In humans, administration of the drugs is not without risk and may result in accidental awareness under general anaesthesia and postoperative residual ...
Kamilla Pedersen +3 more
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Comparative Effectiveness of Calabadion and Sugammadex to Reverse Non-depolarizing Neuromuscular-blocking Agents [PDF]
Anesthesiology, 2015 AbstractAbstract Calabadion 2 rapidly reversed deep rocuronium-, vecuronium-, and cisatracurium-induced neuromuscular blockade in a dose-dependent manner. Calabadion 2 reversed rocuronium- and vecuronium-induced neuromuscularblockade with a 1:1 binding ratio, like sugammadex, but it had a higher in vitro binding affinity and a higher ...
Haerter, Friederike +11 more
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Rocuronium-Sugammadex in Anesthesia for Electroconvulsive Therapy [PDF]
Psikiyatride Güncel Yaklaşımlar, 2016 Electroconvulsive therapy (ECT) is a form of treatment which is very effective in many psychiatric disorders. The administration of anesthesia plays a positive role in the success of ECT and improves the oxygenation of the body during the process ...
Nilay Tas, Esra Yancar Demir
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Pharmacodynamic interactions between muscle relaxants and other medications in practice of anesthesia [PDF]
Farmacja Polska, 2023 Knowledge of drug interactions is an essential element of medical practice. Along with the increasing occurrence of multimorbidity and the associated multi-drug use, the number of possible combinations of preparations is constantly rising.
Paweł Radkowski, Rafał Marek Okoński
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Neuromuscular blockers and their reversal: have we finally found the on-off switches?
Ain Shams Journal of Anesthesiology, 2021 Background A nondepolarizing neuromuscular blocking agent (NMBA) with a succinylcholine-like quick onset and offset has been the holy grail of the science of neuromuscular blockade.
Shagun Bhatia Shah +3 more
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Function and distribution of three types of rectifying channel in rat spinal root myelinated axons [PDF]
, 1987 1. The nature, distribution and function of rectifying channels in rat spinal root myelinated axons has been assessed with selective blocking agents and a variety of intracellular and extracellular recording techniques. 2.
Baker, M. +3 more
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INFLUENCE OF “PRIMING” ON THE POTENCY OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKING AGENTS
British Journal of Anaesthesia, 1987 Dose-response curves have been constructed to determine the ED50 and ED95 (doses required to produce a 50% and a 95% block, respectively) following administration of a small "priming" dose of atracurium 50 micrograms kg-1, vecuronium 10 micrograms kg-1 or pancuronium 10 micrograms kg-1.
M M, Brady, R K, Mirakhur, F M, Gibson
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Are non-depolarizing neuromuscular blocking agents innocuous for the neonates? [PDF]
Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 2005 tions and for the initial injection when a continuous infusion is used (for continuous plexus nerve block analgesia). Unfortunately, the labelled syringe used for continuous infusion is not a dedicated one (30 mL is too small: too frequent changes are needed). We use dedicated coiled lines as well (Figure, Vygon laboratories, Ecouen, France).
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Studies on fazadinium bromide (AH 8165): A new non-depolarizing neuromuscular blocking agent [PDF]
Canadian Anaesthetists’ Society Journal, 1976 Intravenous dose-response relationships were used to correlate neuromuscular paralysis with the effects of fazadinium (AH 8165) on autonomic mechanisms in anaesthetized cats and rhesus monkeys and with cardiovascular effects in man. In cats and monkeys neuromuscular paralysis of the twitch responses of the gastrocnemius muscle by fazadinium was ...
R, Hughes, J P, Payne, N, Sugai
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