Results 1 to 10 of about 1,143,572 (245)

A Surgeon-Centered Neuromuscular Block Protocol Improving Intraoperative Neuromonitoring Outcome of Thyroid Surgery [PDF]

Frontiers in Endocrinology, 2022
BackgroundNeuromuscular blocking agents provide muscular relaxation for tracheal intubation and surgery. However, the degree of neuromuscular block may disturb neuromuscular transmission and lead to weak electromyography during intraoperative ...
I-Cheng Lu, I-Cheng Lu, Chiung-Dan Hsu, Pi-Ying Chang, Sheng-Hua Wu, Sheng-Hua Wu, Tzu-Yen Huang, Tzu-Yen Huang, Yi-Chu Lin, How-Yun Ko, Gianlorenzo Dionigi, Gianlorenzo Dionigi, Young Jun Chai, Feng-Yu Chiang, Yi-Wei Kuo, Che-Wei Wu, Che-Wei Wu   +16 more
doaj   +2 more sources

Is lower-dose sugammadex a cost-saving strategy for reversal of deep neuromuscular block? Facts and fiction

BMC Anesthesiology, 2018
Background Sugammadex, a γ-cyclodextrin derivative, belongs to a new class of selective relaxant binding agents. Sugammadex was approved 10-years ago by the European medicines agency and today is used in clinical anesthesia and emergency medicine ...
Hans D de Boer, Ricardo V Carlos, Sorin J Brull   +2 more
doaj   +2 more sources

Reversal of neuromuscular block with sugammadex in five heart transplant pediatric recipients [PDF]

Brazilian Journal of Anesthesiology, 2018
Heart transplantation is a frequent procedure in the treatment of end-stage cardiac dysfunction. Therefore, these patient populations will also be more frequent exposed to other more common surgical procedures after their transplantation ...
Ricardo Vieira Carlos, Marcelo Luis Abramides Torres, Hans Donald de Boer   +2 more
doaj   +5 more sources

Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell hemolysis

Biochemistry and Biophysics Reports, 2022
Our laboratory focuses on the development of novel neuroprotective cationic peptides, such poly-arginine-18 (R18: 18-mer of l-arginine; net charge +18) and its d-enantiomer R18D in stroke and other brain injuries. In the clinical development of R18/R18D,
Adam B. Edwards, Frank L. Mastaglia, Neville W. Knuckey, Kwok-Ho Yip, Bruno Meloni   +4 more
doaj   +1 more source

Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: an ex vivo laboratory study

BMC Anesthesiology, 2021
Background Residual neuromuscular block at the end of surgery may compromise the patient’s safety. The risk of airway complications can be minimized through monitoring of neuromuscular function and reversal of neuromuscular block if needed.
Ákos I. Fábián, Edömér Tassonyi, Vera Csernoch, Marianna Fedor, Tamás Sohajda, Lajos Szente, Béla Fülesdi   +6 more
doaj   +1 more source

Neuromuscular Weakness and Paralysis Produced by Snakebite Envenoming: Mechanisms and Proposed Standards for Clinical Assessment

Toxins, 2023
Respiratory and airway-protective muscle weakness caused by the blockade of neuromuscular transmission is a major cause of early mortality from snakebite envenoming (SBE).
Philip E. Bickler, Michael Abouyannis, Ashish Bhalla, Matthew R. Lewin   +3 more
doaj   +1 more source

Actual versus ideal body weight dosing of sugammadex in morbidly obese patients offers faster reversal of rocuronium- or vecuronium-induced deep or moderate neuromuscular block: a randomized clinical trial

BMC Anesthesiology, 2021
Background This randomized, double-blind trial evaluated sugammadex-mediated recovery time from rocuronium- or vecuronium-induced moderate (M-) or deep (D-) neuromuscular block in morbidly obese adults dosed by actual (ABW) or ideal body weight (IBW ...
Jay C. Horrow, Wen Li, Manfred Blobner, John Lombard, Marcel Speek, Matthew DeAngelis, W. Joseph Herring   +6 more
doaj   +1 more source

SUGAMMADEX versus neostigmine after ROCURONIUM continuous infusion in patients undergoing liver transplantation

BMC Anesthesiology, 2020
Background Rapid neuromuscular block reversal at the end of major abdominal surgery is recommended to avoid any postoperative residual block. To date, no study has evaluated sugammadex performance after rocuronium administration in patients undergoing ...
Cristian Deana, Federico Barbariol, Stefano D’Incà, Livia Pompei, Giorgio Della Rocca   +4 more
doaj   +1 more source

The influence of moderate or deep neuromuscular block status on anesthetic depth monitoring system during total intravenous anesthesia using propofol and remifentanil: A randomized trial

Science Progress, 2021
The neuromuscular block state may affect the electroencephalogram-derived index representing the anesthetic depth. We applied an Anesthetic Depth Monitoring for Sedation (ADMS) to patients undergoing laparoscopic cholecystectomy under total intravenous ...
Hyo-Seok Na, Dae-Jin Lim, Bon-Wook Koo, Ah-Young Oh, Pyung-Bok Lee   +4 more
doaj   +1 more source

A randomized trial evaluating the safety profile of sugammadex in high surgical risk ASA physical class 3 or 4 participants

BMC Anesthesiology, 2021
Background The aim of this randomized, double-blind trial was to evaluate the safety and tolerability profile, including cardiac safety, of sugammadex-mediated recovery from neuromuscular block in participants undergoing surgery who met the American ...
W. Joseph Herring, Yuki Mukai, Aobo Wang, Jeannine Lutkiewicz, John F. Lombard, Li Lin, Molly Watkins, David M. Broussard, Manfred Blobner   +8 more
doaj   +1 more source