Results 11 to 20 of about 45,078 (254)

Carboxymethyl-γ-cyclodextrin, a novel selective relaxant binding agent for the reversal of neuromuscular block induced by aminosteroid neuromuscular blockers: an ex vivo laboratory study

BMC Anesthesiology, 2021
Background Residual neuromuscular block at the end of surgery may compromise the patient’s safety. The risk of airway complications can be minimized through monitoring of neuromuscular function and reversal of neuromuscular block if needed.
Ákos I. Fábián, Edömér Tassonyi, Vera Csernoch, Marianna Fedor, Tamás Sohajda, Lajos Szente, Béla Fülesdi   +6 more
doaj   +1 more source

Neuromuscular Weakness and Paralysis Produced by Snakebite Envenoming: Mechanisms and Proposed Standards for Clinical Assessment

Toxins, 2023
Respiratory and airway-protective muscle weakness caused by the blockade of neuromuscular transmission is a major cause of early mortality from snakebite envenoming (SBE).
Philip E. Bickler, Michael Abouyannis, Ashish Bhalla, Matthew R. Lewin   +3 more
doaj   +1 more source

Actual versus ideal body weight dosing of sugammadex in morbidly obese patients offers faster reversal of rocuronium- or vecuronium-induced deep or moderate neuromuscular block: a randomized clinical trial

BMC Anesthesiology, 2021
Background This randomized, double-blind trial evaluated sugammadex-mediated recovery time from rocuronium- or vecuronium-induced moderate (M-) or deep (D-) neuromuscular block in morbidly obese adults dosed by actual (ABW) or ideal body weight (IBW ...
Jay C. Horrow, Wen Li, Manfred Blobner, John Lombard, Marcel Speek, Matthew DeAngelis, W. Joseph Herring   +6 more
doaj   +1 more source

SUGAMMADEX versus neostigmine after ROCURONIUM continuous infusion in patients undergoing liver transplantation

BMC Anesthesiology, 2020
Background Rapid neuromuscular block reversal at the end of major abdominal surgery is recommended to avoid any postoperative residual block. To date, no study has evaluated sugammadex performance after rocuronium administration in patients undergoing ...
Cristian Deana, Federico Barbariol, Stefano D’Incà, Livia Pompei, Giorgio Della Rocca   +4 more
doaj   +1 more source

The influence of moderate or deep neuromuscular block status on anesthetic depth monitoring system during total intravenous anesthesia using propofol and remifentanil: A randomized trial

Science Progress, 2021
The neuromuscular block state may affect the electroencephalogram-derived index representing the anesthetic depth. We applied an Anesthetic Depth Monitoring for Sedation (ADMS) to patients undergoing laparoscopic cholecystectomy under total intravenous ...
Hyo-Seok Na, Dae-Jin Lim, Bon-Wook Koo, Ah-Young Oh, Pyung-Bok Lee   +4 more
doaj   +1 more source

Is lower-dose sugammadex a cost-saving strategy for reversal of deep neuromuscular block? Facts and fiction

BMC Anesthesiology, 2018
Background Sugammadex, a γ-cyclodextrin derivative, belongs to a new class of selective relaxant binding agents. Sugammadex was approved 10-years ago by the European medicines agency and today is used in clinical anesthesia and emergency medicine ...
Hans D de Boer, Ricardo V Carlos, Sorin J Brull   +2 more
doaj   +1 more source

Neuromuscular block [PDF]

British Journal of Pharmacology, 2006
Descriptions of the South American arrow poisons known as curares were reported by explorers in the 16th century, and their site of action in producing neuromuscular block was determined by Claude Bernard in the mid‐19th century. Tubocurarine, the most important curare alkaloid, played a large part in experiments to determine the role of acetylcholine ...
openaire   +2 more sources

A randomized trial evaluating the safety profile of sugammadex in high surgical risk ASA physical class 3 or 4 participants

BMC Anesthesiology, 2021
Background The aim of this randomized, double-blind trial was to evaluate the safety and tolerability profile, including cardiac safety, of sugammadex-mediated recovery from neuromuscular block in participants undergoing surgery who met the American ...
W. Joseph Herring, Yuki Mukai, Aobo Wang, Jeannine Lutkiewicz, John F. Lombard, Li Lin, Molly Watkins, David M. Broussard, Manfred Blobner   +8 more
doaj   +1 more source

Farmacodinâmica do cisatracúrio no transplante renal Farmacodinámica del cisatracúrio en el transplante renal Cisatracurium pharmacodynamics in renal transplantation

Revista Brasileira de Anestesiologia, 2002
JUSTIFICATIVA E OBJETIVOS: A escolha do cisatracúrio, especialmente nos doentes com insuficiência orgânica, parece ser benéfica, devido a sua eliminação órgão independente de Hofmann e menor tendência a liberar histamina.
Ismar Lima Cavalcanti, Maria Angela Tardelli, Rita de Cássia Rodrigues   +2 more
doaj   +1 more source

Effect of epidural block on surgical conditions during pediatric subumbilical laparoscopic surgery involving a supraglottic airway: a randomized clinical trial

Frontiers in Medicine, 2023
BackgroundFew studies have examined the effect of epidural block on surgical conditions during pediatric subumbilical laparoscopic surgery involving a supraglottic airway (SGA). This study investigated the surgical condition scores for such procedures in
Lei Wu, Siwei Wei, Zhen Xiang, Eryou Yu, Zheng Chen, Zhen Du, Shuang Quan Qu   +6 more
doaj   +1 more source