Neuromuscular depolarizing agents

2017
Succinylcholine was first introduced into clinical practice in the 1950s, and is currently the only depolarizing neuromuscular blocker in use. It is unique among the drugs used for muscle relaxation in its rapid onset and short duration of action. These characteristics account for its extensive use in scenarios requiring emergency control of the airway.
Caroline S. Gross, Zhiling Xiong
exaly +2 more sources

Interactions between ORG9426 and other non-depolarizing neuromuscular blocking agents in ratsin vivo

Journal of Anesthesia, 1992
In this study, combined neuromuscular blocking effects of ORG9426 with other non-depolarizing neuromuscular blocking agents were investigated. About 20% steady state neuromuscular block was established by a continuous infusion of one of 6 neuromuscular blocking agents (ORG9426, vecuronium, pancuronium, pipecuronium, d-tubocurarine and metocurine). Then
Kazuhiko Watanabe
exaly +3 more sources

Increased Sensitivity to Depolarizing and Nondepolarizing Neuromuscular Blocking Agents in Young Rat Hemidiaphragms

Anesthesiology, 2001
Background Newborn neuromuscular junctions are more sensitive to d-tubocurarine than more mature preparations. It is unclear whether the same modifications occur with newer nondepolarizing agents and depolarizing agent succinylcholine.
François Donati
exaly +3 more sources

neuromuscular nondepolarizing agents
3. good health
humans

animals
neuromuscular blocking agents
sugammadex

female
neuromuscular junction
rocuronium