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Succinylcholine is still used in clinical practice. Its duration is highly variable and neuromuscular monitoring is recommended to assess its recovery. Unfortunately, depolarizing neuromuscular block cannot be evaluated by train-of-four (TOF) as no fade ...
Denis Schmartz
exaly +2 more sources
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An analytical pharmacodynamic model for nondepolarizing neuromuscular blocking agents
Journal of Pharmacokinetics and Biopharmaceutics, 1981A pharmacodynamic model for nondepolarizing neuromuscular blocking agents (NMBA) is developed and tested with different sets of data (NMBA plasma concentration and time evolution of muscular paralysis). This model takes into account the binding of NMBA to the cholinergic motor endplate receptors and thus permits estimation of the apparent equilibrium ...
D'Hollander, Alain, Delcroix, Claude
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Acta anaesthesiologica Sinica, 1998
Rocuronium is a new nondepolarizing muscle relaxant. It features a rapid onset and lack of histamine release: It has an intermediate onset of action as vecuronium. The purpose of this study was to compare the neuromuscular action and condition of intubation after a bolus dose of rocuronium or vecuronium (2 x ED90).
P L, Lin +5 more
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Rocuronium is a new nondepolarizing muscle relaxant. It features a rapid onset and lack of histamine release: It has an intermediate onset of action as vecuronium. The purpose of this study was to compare the neuromuscular action and condition of intubation after a bolus dose of rocuronium or vecuronium (2 x ED90).
P L, Lin +5 more
openaire +1 more source
Arzneimittel-Forschung, 1982
The pharmacokinetics of 2 beta, 16 beta-bis-(4'-dimethyl-1'-piperazino)-3 alpha, 17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, Arduan), a new non-depolarizing neuromuscular blocking agent, was studied in surgical patients. Plasma concentration-time curves of pipecurium bromide were evaluated by fitting the data to a bi-exponential
E, Tassonyi, G, Szabó, L, Vereczkey
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The pharmacokinetics of 2 beta, 16 beta-bis-(4'-dimethyl-1'-piperazino)-3 alpha, 17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, Arduan), a new non-depolarizing neuromuscular blocking agent, was studied in surgical patients. Plasma concentration-time curves of pipecurium bromide were evaluated by fitting the data to a bi-exponential
E, Tassonyi, G, Szabó, L, Vereczkey
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Arzneimittel-Forschung, 1981
A method for the determination of 2 beta, 16 beta-bis (4'dimethyl-1'-piperazino)-3a, 17 beta-diacetoxy-5 alpha-androstane is described. After deproteinization a pipecurium bromide Rose Bengal complex is formed and extracted with chloroform from a mildly basic medium.
G, Szabó, E, Tassonyi
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A method for the determination of 2 beta, 16 beta-bis (4'dimethyl-1'-piperazino)-3a, 17 beta-diacetoxy-5 alpha-androstane is described. After deproteinization a pipecurium bromide Rose Bengal complex is formed and extracted with chloroform from a mildly basic medium.
G, Szabó, E, Tassonyi
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Neuromuscular blocking agents and reversal agents
Anaesthesia and Intensive Care Medicine, 2021Jennifer Hunter
exaly
European journal of anaesthesiology. Supplement, 1994
The safety of neuromuscular relaxants can be assessed according to their cardiovascular and autonomic effects, their liability to release histamine, their tendency to cause anaphylactic/anaphylactoid reactions, their effect on cholinesterase, on intra-ocular and intracranial pressure, their tendency to cumulation and their reversibility.
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The safety of neuromuscular relaxants can be assessed according to their cardiovascular and autonomic effects, their liability to release histamine, their tendency to cause anaphylactic/anaphylactoid reactions, their effect on cholinesterase, on intra-ocular and intracranial pressure, their tendency to cumulation and their reversibility.
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The depolarizing and non-depolarizing neuromuscular blocking agents.
Wisconsin medical journal, 1974S, Lamid, R I, Wang
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The interactions of hexafluorenium with depolarizing and competitive neuromuscular blocking agents.
Archives internationales de pharmacodynamie et de therapie, 1974SCAF, AHJ +2 more
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