Results 81 to 90 of about 2,421,984 (303)

Improving physical fitness in neuromuscular diseases [PDF]

Physical inactivity is common among people with neuromuscular diseases due to symptoms such as muscle weakness, fatigue, and pain. Inactivity reduces physical fitness and is assumed to negatively impact on general health, daily functioning, and societal ...
Oorschot, S.
core   +4 more sources

Anaesthesia in children with inherited neuromuscular diseases [PDF]

, 2010
Children with inherited neuromuscular diseases often require anaesthesia for diagnostic or therapy procedures. These patients have an increased risk of perioperative complications due to the nature of the disease and medications administered during ...
Marković Marija, Simić Dušica, Bogićević Dragana, Budić Ivana, Milojević Irina   +4 more
core   +2 more sources

The Neuromuscular diseases in Pediatric Dental Office

, 2017
The neuromuscular disorders may be hereditary, autoimmune, and in some cases with unknown etiology. These diseases are characterized by progressive course, muscle weakness, and in an advanced stage with binding the patient to a wheelchair.
Vesna Ambarkova, Ambarkova Vesna*
core   +1 more source

Advances in Treatment of ATTRv Amyloidosis: State of the Art and Future Prospects

Brain Sciences, 2020
Hereditary amyloid transthyretin (ATTRv) amyloidosis with polyneuropathy is a progressive disease that is transmitted as an autosomal dominant trait and characterized by multiple organ failure, including axonal sensory-motor neuropathy, cardiac ...
Massimo Russo, Luca Gentile, Antonio Toscano, M’Hammed Aguennouz, Giuseppe Vita, Anna Mazzeo   +5 more
doaj   +1 more source

Anorectal Dysfunction in Systemic Sclerosis: Clinical Phenotypes and Functional Patterns

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to characterize specific physiologic defects in anorectal dysfunction in systemic sclerosis (SSc) using anorectal manometry (ARM), evaluate associations with gastrointestinal (GI) and extraintestinal clinical phenotypes, and explore potential serologic markers for risk stratification.
Timothy Kaniecki, Alireza Amindarolzarbi, Tsion Abdi, John Clarke, Michael Hughes, Ami A. Shah, Zsuzsanna H. McMahan   +6 more
wiley   +1 more source

Diseases of the neuromuscular junction

Current Opinion in Pharmacology, 2002
The neuromuscular junction is a prototype synapse and it is also the site of well-characterised autoimmune and hereditary disorders. In the presynaptic terminal, voltage-gated potassium channels and voltage-gated calcium channels are subtly altered in genetic disorders and mutations in the enzyme that synthesises acetylcholine have been demonstrated in
McConville, J, Vincent, A
openaire   +3 more sources

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High BMI: A Secondary Analysis of the IDEA Trial

Arthritis Care &Research, Accepted Article.
Objective High body mass index (BMI≥27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

DIAGNOSIS IN NEUROMUSCULAR DISEASES

Neurologic Clinics, 1996
The diagnosis of neuromuscular diseases can be challenging and successful in the majority of patients, due to advancements in electrophysiology, muscle and nerve biopsy immunohistochemistry, and cytogenetics. This article reviews diverse topics, highlighting these recent achievements, with an emphasis on how they affect the clinical and laboratory ...
D S, Younger, P H, Gordon
openaire   +2 more sources

Cognitive impairment in neuromuscular diseases: A systematic review

, 2018
Neuromuscular diseases are multifactorial pathologies characterized by extensive muscle fiber damage that leads to the activation of satellite cells and to the exhaustion of their pool, with consequent impairment of neurobiological aspects, such as ...
Anna Carolina Damm de Assis, Rossano Fiorelli, Ana Carolina Andorinho de F. Ferreira, Silmar Teixeira, Acary Bulle Oliveira, Thais Magalhães, Thomaz Oliveira, Victor Marinho, Marcos R. G. de Freitas, Victor Hugo Bastos, Marco Orsini   +10 more
core   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source