The binding of botulinum neurotoxins to different peripheral neurons [PDF]
, 2017 Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
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Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome
Case Reports in Neurological Medicine, 2016 Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of
Stéphane Mathis +7 more
doaj +1 more source
E‐Textiles in Biomedicine: Real Time Sensing, Energy Storage, and Therapeutic Applications
Advanced Materials Interfaces, EarlyView.E‐textiles merge electronics with fabrics to create intelligent, wearable systems for health, sports, and fashion. By embedding sensors, actuators, and conductive components, these textiles provide real‐time physiological monitoring. Complemented by flexible power sources including embedded batteries and energy‐harvesting technologies, e‐textiles ...
Shiva Sharma +4 more
wiley +1 more source
Early exposure to environmental toxin contributes to neuronal vulnerability and axonal pathology in a model of familial ALS [PDF]
, 2011 Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons.
Christopher A. Shaw, Grace Lee
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Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer [PDF]
, 2005 Lysosomal storage is the most common cause of neurodegenerative brain disease in preadulthood. However, the underlying cellular mechanisms that lead to neuronal dysfunction are unknown.
Bellen, Hugo J +7 more
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Flexible Sensor‐Based Human–Machine Interfaces with AI Integration for Medical Robotics
Advanced Robotics Research, EarlyView.This review explores how flexible sensing technology and artificial intelligence (AI) significantly enhance human–machine interfaces in medical robotics. It highlights key sensing mechanisms, AI‐driven advancements, and applications in prosthetics, exoskeletons, and surgical robotics.
Yuxiao Wang +5 more
wiley +1 more source
Dropped head syndrome due to neuromuscular disease: clinical manifestation and evaluation
Neurology International, 2019 In this article, we discuss the clinical approach to patients with dropped head syndrome and identify the various neuromuscular causes of dropped head syndrome, including muscle, neuromuscular junction, peripheral nerve, and motor neuron etiologies.
Ahmet Burakgazi +2 more
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Soft Actuators Integrated with Control and Power Units: Approaching Wireless Autonomous Soft Robots
Advanced Robotics Research, EarlyView.Soft robots exhibit significant development potential in various applications. However, there are still key technical challenges regarding material improvement, structure design and components integration. This review focuses on the development and challenge of soft actuators, power components, and control components in untethered intelligent soft ...
Renwu Shi, Feifei Pan, Xiaobin Ji
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Skeletal muscle mTORC1 regulates neuromuscular junction stability
Journal of Cachexia, Sarcopenia and Muscle, 2020 Background Skeletal muscle is a plastic tissue that can adapt to different stimuli. It is well established that Mammalian Target of Rapamycin Complex 1 (mTORC1) signalling is a key modulator in mediating increases in skeletal muscle mass and function ...
Martina Baraldo +12 more
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Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity
Advanced Science, EarlyView.This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong +16 more
wiley +1 more source