Results 111 to 120 of about 666,453 (371)

MuSK Frizzled-Like Domain Is Critical for Mammalian Neuromuscular Junction Formation and Maintenance

Journal of Neuroscience, 2015
The muscle-specific kinase MuSK is one of the key molecules orchestrating neuromuscular junction (NMJ) formation. MuSK interacts with the Wnt morphogens, through its Frizzled-like domain (cysteine-rich domain [CRD]).
J. Messéant, A. Dobbertin, E. Girard, P. Delers, Marin Manuel, F. Mangione, A. Schmitt, D. Le Denmat, J. Molgó, D. Zytnicki, L. Schaeffer, C. Legay, L. Strochlic   +12 more
semanticscholar   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles [PDF]

, 2018
Available under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.Peer reviewedPublisher ...
Bewick, Guy Smith, Lomo, T., Martinov, V. N., Nja, A., Reid, Brian   +4 more
core   +1 more source

Pathogenesis of myasthenia gravis: update on disease types, models, and mechanisms [version 1; referees: 2 approved]

F1000Research, 2016
Myasthenia gravis is an autoimmune disease of the neuromuscular junction (NMJ) caused by antibodies that attack components of the postsynaptic membrane, impair neuromuscular transmission, and lead to weakness and fatigue of skeletal muscle.
William D. Phillips, Angela Vincent
doaj   +1 more source

Development of the vertebrate neuromuscular junction.

Annual Review of Neuroscience, 1999
We describe the formation, maturation, elimination, maintenance, and regeneration of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses.
J. Sanes, J. Lichtman
semanticscholar   +1 more source

Evolutionary Codesign and Fabrication of Tensegrity Joints with Integrated Pneumatic Artificial Muscles

Advanced Intelligent Systems, EarlyView.
This study presents a tensegrity joint with pneumatic artificial muscles integrated directly into its tensile network. Inspired by tensegrity spine structures, the joint's topology is developed and further optimized through an evolutionary algorithm, taking into account fabrication constraints and target applications.
Jan Petrš, Ryota Kobayashi, Fuda van Diggelen, Hiroyuki Nabae, Koichi Suzumori, Dario Floreano   +5 more
wiley   +1 more source

Peripheral nerve and neuromuscular junction pathology in Pompe disease.

Human Molecular Genetics, 2015
Pompe disease is a systemic metabolic disorder characterized by lack of acid-alpha glucosidase (GAA) resulting in ubiquitous lysosomal glycogen accumulation.
D. Falk, A. G. Todd, Sooyeon Lee, M. Soustek, M. ElMallah, D. Fuller, L. Notterpek, B. Byrne   +7 more
semanticscholar   +1 more source

Patient With Prolidase Deficiency due to an Homozygous PEPD Variant, Induced by Paternal Uniparental Isodisomy of Chromosome 19

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Uniparental disomy (UPD) is a rare phenomenon in which both copies of a chromosome are inherited from a single parent. This can lead to genomic imprinting disorders and recessive disorders due to the presence of recessive pathogenic variants in both alleles. Additionally, depending on the mechanisms by which UPD occurs, mosaic aneuploidies may
Marta Carreño‐Hidalgo, Raquel Muñoz‐Siles, Vanesa López‐González, Lidia Carreño‐Gago, Lluís Armengol Dulcet   +4 more
wiley   +1 more source

The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice [PDF]

, 2013
Gangliosides are glycosphingolipids highly enriched in neural plasma membranes, where they mediate a diverse range of functions and can act as targets for auto-antibodies present in human immune-mediated neuropathy sera.
Cunningham, Madeleine E., Furukawa, Koichi, Rupp, Angie, Willison, Hugh J., Yao, Denggao   +4 more
core   +1 more source

Cross‐disease comparison of amyotrophic lateral sclerosis and spinal muscular atrophy reveals conservation of selective vulnerability but differential neuromuscular junction pathology

The Journal of comparative neurology, 2015
Neuromuscular junctions are primary pathological targets in the lethal motor neuron diseases spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
L. Comley, Jik Nijssen, Johanna Frost-Nylén, E. Hedlund   +3 more
semanticscholar   +1 more source