Results 61 to 70 of about 615,784 (234)
Frontiers in Neuroscience, 2016 We report the methodology for the chronic delivery of an excitotoxin to the mouse spinal cord via surgically implanted osmotic mini-pumps. Previous studies have investigated the effect of chronic application of excitotoxins in the rat, however there has ...
Catherine A Blizzard +2 more
doaj +1 more source
A system for studying mechanisms of neuromuscular junction development and maintenance
Development, 2016 The neuromuscular junction (NMJ), a cellular synapse between a motor neuron and a skeletal muscle fiber, enables the translation of chemical cues into physical activity.
Valérie Vilmont +3 more
semanticscholar +1 more source
Aging, 2016 Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Leslie M. Baehr +6 more
semanticscholar +1 more source
The importance of early diagnosis and treatment in treatable neuromuscular diseases
Chinese Journal of Contemporary Neurology and Neurosurgery, 2018 Neuromuscular diseases represent a heterogeneous group of disorders involving peripheral nerves, neuromuscular junction (NMJ) and skeletal muscle. The most common symptoms are muscular weakness and amyotrophy in different body parts to varying degrees ...
Cheng ZHANG, Yu-ling ZHU
doaj +1 more source
Pre- and postsynaptic changes in the neuromuscular junction in dystrophic mice
Frontiers in Physiology, 2015 Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which weakness, increased susceptibility to muscle injury, and inadequate repair appear to underlie the pathology.
S. J. Pratt +4 more
semanticscholar +1 more source
Tissue Engineering. Part A, 2015 Neuromuscular and neurodegenerative diseases are conditions that affect both motor neurons and the underlying skeletal muscle tissue. At present, the majority of neuromuscular research utilizes animal models and there is a growing need to develop novel ...
N. R. Martin +6 more
semanticscholar +1 more source
MuSK Frizzled-Like Domain Is Critical for Mammalian Neuromuscular Junction Formation and Maintenance
Journal of Neuroscience, 2015 The muscle-specific kinase MuSK is one of the key molecules orchestrating neuromuscular junction (NMJ) formation. MuSK interacts with the Wnt morphogens, through its Frizzled-like domain (cysteine-rich domain [CRD]).
J. Messéant +12 more
semanticscholar +1 more source
Development of the vertebrate neuromuscular junction.
Annual Review of Neuroscience, 1999 We describe the formation, maturation, elimination, maintenance, and regeneration of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses.
J. Sanes, J. Lichtman
semanticscholar +1 more source
alpha-Actinin interacts with rapsyn in agrin-stimulated AChR clustering
Molecular Brain, 2008 AChR is concentrated at the postjunctional membrane at the neuromuscular junction. However, the underlying mechanism is unclear. We show that α-actinin, a protein known to cross-link F-actin, interacts with rapsyn, a scaffold protein essential for ...
Dobbins G Clement +4 more
doaj +1 more source
Peripheral nerve and neuromuscular junction pathology in Pompe disease.
Human Molecular Genetics, 2015 Pompe disease is a systemic metabolic disorder characterized by lack of acid-alpha glucosidase (GAA) resulting in ubiquitous lysosomal glycogen accumulation.
D. Falk +7 more
semanticscholar +1 more source