Results 41 to 50 of about 59,521 (252)

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Diaphragm ultrasonography as a monitor in assessing antagonistic effect of sugammadex on rocuronium in patients with Child-Pugh grades A and B

Frontiers in Medicine
BackgroundAlthough diaphragm ultrasound can be used for detecting residual neuromuscular blockade post-surgery, there exists notable dearth in contemporary research exploring the correlation between preoperative Child-Pugh classification and the ...
Yan Sun, Yan Sun, Yan Sun, Shujun Sun, Shujun Sun, Shujun Sun, Rui Chen, Rui Chen, Rui Chen, Jiwei Shen, Jiwei Shen, Jiwei Shen, Xiangdong Chen, Xiangdong Chen, Xiangdong Chen, Yun Lin, Yun Lin, Yun Lin, Shanglong Yao, Shanglong Yao, Shanglong Yao   +20 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Current status of neuromuscular reversal and neuromuscular monitoring in China: a cross-sectional survey

BMC Anesthesiology
Background and objective Residual neuromuscular blockade (rNMB) is associated with perioperative pulmonary complications. Effective neuromuscular monitoring and the use of reversal agents can help reduce rNMB.
Jia-chun Tao, Xiang-yong Zhou, Ting-ting Wang, Qi Gao, Yuan-yuan Yao   +4 more
doaj   +1 more source

Mechanism-Based Modeling of Neuromuscular Monitoring Measures During General Anesthesia

IEEE Access
This study presents a mechanism-based model of neuromuscular transmission that incorporates the effects of Non-depolarizing Neuromuscular Blockers (NDNBs) used in general anesthesia. NDNBs act on acetylcholine receptors at both the pre- and post-synaptic
Hikaru Hoshino, Hiroki Miyaguchi, Eiko Furutani, Tomonori Sugawara, Toshihiro Takeda, Gotaro Shirakami   +5 more
doaj   +1 more source

Not just small adults–practical pearls in pediatric anesthesia: a narrative review [PDF]

The Ewha Medical Journal
Pediatric anesthesia presents unique challenges due to children’s distinct physiological and anatomical characteristics, including variations in drug metabolism, airway structure, and respiratory and circulatory regulation.
Hee Young Kim
doaj   +1 more source

Comparison of the neuromuscular effects of two infusion rates of rocuronium in anesthetized pigs

Acta Veterinaria Scandinavica, 2022
Background: Neuromuscular blocking agents are frequently administered to pigs used for research. In humans, administration of the drugs is not without risk and may result in accidental awareness under general anaesthesia and postoperative residual ...
Kamilla Pedersen, Linda Loisa Kruhøffer, Jens Lykkesfeldt, Birgitte Saima Kousholt   +3 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Dose–Response Evaluation of Sugammadex for Reversal of Deep Rocuronium-Induced Neuromuscular Block in Cats

Veterinary Sciences
Background: Sugammadex is a selective γ-cyclodextrin compound that encapsulates steroidal neuromuscular blocking agents such as rocuronium, allowing rapid and predictable recovery from neuromuscular block (NMB).
Natália Mesquita Cesnik, Karina D’Angelo Campos, Jéssica Sperandio Cavaco, Carolina Soares Navarro, André Gustavo Alves Holanda, Julia Maria Matera, Aline Magalhães Ambrósio   +6 more
doaj   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source