Results 121 to 130 of about 1,612 (159)

Interaction Between Nondepolarizing Neuromuscular Blocking Agents and Inhalational Anesthetics

Anesthesia & Analgesia, 1989
Although many studies have presented data based on administration of nondepolarizing neuromuscular blocking agents to patients given inhalation anesthesia for 30-45 min, no data exist on the interaction in a clinical situation where the relaxant is administered immediately after the start of anesthesia.
Jantine M. Ket, Joseph Swen, Jo Hermans, Omar M. Rashkovsky, Sandor Agoston, Henk W. J. Koot   +5 more
openaire   +4 more sources

Fumarates: Unique nondepolarizing neuromuscular blocking agents that are antagonized by cysteine

Journal of Critical Care, 2009
It has been almost 20 years since the introduction of the last new nondepolarizing neuromuscular blocking agent into clinical practice, and research is ongoing to fill a clinical need for a nondepolarizing agent with a fast onset of effect and a short duration of action, as described by Savarese and Kitz [1] in 1975.
Cynthia A. Lien, Hiorshi Sunaga, Matthew R. Belmont, John J. Savarese, Peter M. Savard   +4 more
openaire   +3 more sources

Prolonged paralysis due to nondepolarizing neuromuscular blocking agents and corticosteroids

Muscle & Nerve, 1994
AbstractThe long‐term use of nondepolarizing neuromuscular blocking agents (ND‐NMBA) has recently been implicated as a cause of prolonged muscle weakness, although the site of the lesion and the predisposing factors have been unclear. We report 3 patients (age 37–52 years) with acute respiratory insufficiency who developed prolonged weakness following ...
Carlayne E. Jackson, Susan J. Rogers, April L. McVey, Larry W. Ridings, Richard J. Barohn   +4 more
openaire   +3 more sources

Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia

Survey of Anesthesiology, 2016
AbstractBackgroundResidual postoperative paralysis from nondepolarizing neuromuscular blocking agents (NMBAs) is a known problem. This paralysis has been associated with impaired respiratory function, but the clinical significance remains unclear. The aims of this analysis were two-fold: (1) to investigate if intermediate-acting NMBA use during surgery
Maxim A. Terekhov, Barbara J. Martin, Catherine M. Bulka, Roger R. Dmochowski, Jesse M. Ehrenfeld, Rachel M. Hayes   +5 more
openaire   +3 more sources

The Impact of Practice Guidelines on Prescribing Patterns of Nondepolarizing Neuromuscular Blocking Agents

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1996
Guidelines for selecting nondepolarizing neuromuscular blocking agents (NNMBAs) were developed and implemented by an interdisciplinary team for use in our intensive care units. They suggest pancuronium as the drug of choice if the patient does not have renal insufficiency and is hemodynamically stable. If either of these criteria is not met and hepatic
Suzanne J. Tschida, Kyle Vance-Bryan, Lori L. Hoey   +2 more
openaire   +2 more sources

Increased Sensitivity to Depolarizing and Nondepolarizing Neuromuscular Blocking Agents in Young Rat Hemidiaphragms

Anesthesiology, 2001
Background Newborn neuromuscular junctions are more sensitive to d-tubocurarine than more mature preparations. It is unclear whether the same modifications occur with newer nondepolarizing agents and depolarizing agent succinylcholine.
Richard Robitaille, François Donati, L. Philippe Fortier   +2 more
openaire   +3 more sources

Reversal agents for nondepolarizing neuromuscular blockade: Reasons for and development of a new concept

Seminars in Anesthesia, Perioperative Medicine and Pain, 2002
T HE INTRODUCTION of muscle relaxants into clinical anesthesia had an enormous impact on the possibilities of the surgical treatment of patients. The development of cleaner and shorteracting nondepolarizers with a benzylisoquinoline or a steroidal chemical structure further improved clinical anesthesia.
Jan van Egmond, Leo H. D. J. Booij, Hans D. de Boer   +2 more
openaire   +2 more sources

Nondepolarizing Neuromuscular Blocking Agents

2017
Neuromuscular blocking medications are an important part of the anesthetic management of many patients undergoing surgery. These drugs act at the neuromuscular junction on postsynaptic acetylcholine receptors. Muscle relaxants can be divided into depolarizing and nondepolarizing categories. Succinylcholine is the only depolarizing neuromuscular blocker
Zhiling Xiong, Erin Bettendorf
openaire   +2 more sources

Inhibition of human plasma cholinesterase and erythrocyte acetylcholinesterase by nondepolarizing neuromuscular blocking agents

Journal of Anesthesia, 2000
The kinetics of the inhibition of human plasma cholinesterase (ChE) and erythrocyte acetylcholinesterase (AChE) by alcuronium, atracurium, d-tubocurarine, pancuronium, pipecuronium, and vecuronium were studied in blood drawn from 35 surgical patients.The activities of plasma ChE and erythrocyte AChE were determined by the calorimetric method of Ellman ...
Yasuhiko Hashimoto, Hiroyuki Yamanaka, Takashi Horinouchi, Jun Ito, Taishi Ando, Masato Kato   +5 more
openaire   +3 more sources

Effects of Neostigmine Reversal of Nondepolarizing Neuromuscular Blocking Agents on Postoperative Respiratory Outcomes

Anesthesiology, 2014
Abstract Background: We tested the hypothesis that neostigmine reversal of neuromuscular blockade reduced the incidence of signs and symptoms of postoperative respiratory failure. Methods: We enrolled 3,000 patients in this prospective, observer-blinded, observational ...
Sasaki, Nobuo, Meyer, Matthew J, Malviya, Sanjana A, Stanislaus, Anne B, MacDonald, Teresa, Doran, Mary E, Igumenshcheva, Arina, Hoang, Alan H, Eikermann, Matthias   +8 more
openaire   +4 more sources