Results 121 to 130 of about 1,162 (153)
Seminars in Anesthesia, Perioperative Medicine and Pain, 2002 T HE INTRODUCTION of muscle relaxants into clinical anesthesia had an enormous impact on the possibilities of the surgical treatment of patients. The development of cleaner and shorteracting nondepolarizers with a benzylisoquinoline or a steroidal chemical structure further improved clinical anesthesia.
L.H.D.J. Booij +2 more
openalex +3 more sources
The Quest for a Short‐Acting Nondepolarizing Neuromuscular Blocking Agent
Acta Anaesthesiologica Scandinavica, 1974 Current developments in the pharmacology of neuromuscular blocking agents indicate that within the next several years, nondepolarizing drugs of short and intermediate duration of action, devoid of significant side effects, may become a reality. The important factors which may permit their development are reviewed.
John J. Savarese, Richard J. Kitz
openalex +4 more sources
Acta Anaesthesiologica Scandinavica, 1999 Background: Chances are slim that a clinically useful ultra‐short‐acting neuromuscular blocking agent of rapid onset will emerge from the benzylisoquinolinium or the aminosteroid series to which all currently popular relaxants belong. G‐1–64 is a promising prototype of a new series of bis‐quaternary ammonium salt of bistropinyl diester derivatives we ...
Laszlo Gyermek +2 more
openalex +4 more sources
An analytical pharmacodynamic model for nondepolarizing neuromuscular blocking agents
Journal of Pharmacokinetics and Biopharmaceutics, 1981 A pharmacodynamic model for nondepolarizing neuromuscular blocking agents (NMBA) is developed and tested with different sets of data (NMBA plasma concentration and time evolution of muscular paralysis). This model takes into account the binding of NMBA to the cholinergic motor endplate receptors and thus permits estimation of the apparent equilibrium ...
Alain D’Hollander, Claude Delcroix
openalex +5 more sources
World Journal of Surgery, 2009 AbstractBackgroundA short‐acting depolarizing neuromuscular blocking agent (NMBA), succinylcholine, has been utilized for thyroid operations with intraoperative neuromonitoring (IONM). Because of its potential to cause serious side effects, this prospective study tried to determine the feasibility of IONM after administration of a nondepolarizing NMBA ...
Koung‐Shing Chu +7 more
openalex +4 more sources
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1996 Guidelines for selecting nondepolarizing neuromuscular blocking agents (NNMBAs) were developed and implemented by an interdisciplinary team for use in our intensive care units. They suggest pancuronium as the drug of choice if the patient does not have renal insufficiency and is hemodynamically stable. If either of these criteria is not met and hepatic
Suzanne J. Tschida +2 more
openalex +3 more sources
Critical Care Medicine, 2000 Long-term treatment with nondepolarizing neuromuscular blocking agents and corticosteroids in the intensive care unit is not benign, and an increasing number of patients with acute quadriplegic myopathy have been reported with increased use of these drugs.
Lars Larsson +6 more
+6 more sources
The Journal of Pharmacology and Experimental Therapeutics, 1984 The effects of the nondepolarizing agent pancuronium and three derivatives on end-plate currents (e.p.c.s), evoked by neural stimulation at the amphibian neuromuscular junction, were investigated using conventional voltage clamp techniques. All four agents depressed peak e.p.c.
N. N. Durant, R Horn
openalex +3 more sources
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1984 Vecuronium provides additional flexibility to the clinician using neuromuscular‐blocking drugs. Its shorter duration of action, lack of significant cardiovascular effects and lack of dependence on the kidney for elimination provide clinical advantages over, or alternatives to, currently available, nondepolarizing neuromuscular‐blocking drugs.
Ronald D. Miller
openalex +4 more sources
Anesthesia & Analgesia, 2017 BACKGROUND:Nondepolarizing neuromuscular blocking drugs (NNMBDs) are commonly used as an adjunct to general anesthesia. Residual blockade is common, but its potential adverse effects are incompletely known. This study was designed to assess the association between NNMBD use with or without neostigmine reversal and postoperative morbidity and mortality ...
Michael R. Bronsert +8 more
openalex +4 more sources