Results 131 to 140 of about 1,612 (159)
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An analytical pharmacodynamic model for nondepolarizing neuromuscular blocking agents
Journal of Pharmacokinetics and Biopharmaceutics, 1981A pharmacodynamic model for nondepolarizing neuromuscular blocking agents (NMBA) is developed and tested with different sets of data (NMBA plasma concentration and time evolution of muscular paralysis). This model takes into account the binding of NMBA to the cholinergic motor endplate receptors and thus permits estimation of the apparent equilibrium ...
D'Hollander, Alain, Delcroix, Claude
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World Journal of Surgery, 2009
AbstractBackgroundA short‐acting depolarizing neuromuscular blocking agent (NMBA), succinylcholine, has been utilized for thyroid operations with intraoperative neuromonitoring (IONM). Because of its potential to cause serious side effects, this prospective study tried to determine the feasibility of IONM after administration of a nondepolarizing NMBA ...
I-Cheng Lu +7 more
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AbstractBackgroundA short‐acting depolarizing neuromuscular blocking agent (NMBA), succinylcholine, has been utilized for thyroid operations with intraoperative neuromonitoring (IONM). Because of its potential to cause serious side effects, this prospective study tried to determine the feasibility of IONM after administration of a nondepolarizing NMBA ...
I-Cheng Lu +7 more
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The Journal of Pharmacology and Experimental Therapeutics, 1984
The effects of the nondepolarizing agent pancuronium and three derivatives on end-plate currents (e.p.c.s), evoked by neural stimulation at the amphibian neuromuscular junction, were investigated using conventional voltage clamp techniques. All four agents depressed peak e.p.c.
N N, Durant, R, Horn
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The effects of the nondepolarizing agent pancuronium and three derivatives on end-plate currents (e.p.c.s), evoked by neural stimulation at the amphibian neuromuscular junction, were investigated using conventional voltage clamp techniques. All four agents depressed peak e.p.c.
N N, Durant, R, Horn
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Anesthesia & Analgesia, 1975
It is readily evident that a short-acting nondepolarizing agent suitable for clinical use would be of value in anesthesiology. The most commonly used short-acting relaxant, succinylcholine, is a depolarizing drug, with all the side effects inherent in such agents.
John J. Savarese +2 more
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It is readily evident that a short-acting nondepolarizing agent suitable for clinical use would be of value in anesthesiology. The most commonly used short-acting relaxant, succinylcholine, is a depolarizing drug, with all the side effects inherent in such agents.
John J. Savarese +2 more
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Acta Anaesthesiologica Scandinavica, 1999
Background: Chances are slim that a clinically useful ultra‐short‐acting neuromuscular blocking agent of rapid onset will emerge from the benzylisoquinolinium or the aminosteroid series to which all currently popular relaxants belong. G‐1–64 is a promising prototype of a new series of bis‐quaternary ammonium salt of bistropinyl diester derivatives we ...
Laszlo Gyermek, N Nguyen, C Lee
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Background: Chances are slim that a clinically useful ultra‐short‐acting neuromuscular blocking agent of rapid onset will emerge from the benzylisoquinolinium or the aminosteroid series to which all currently popular relaxants belong. G‐1–64 is a promising prototype of a new series of bis‐quaternary ammonium salt of bistropinyl diester derivatives we ...
Laszlo Gyermek, N Nguyen, C Lee
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Anesthesia & Analgesia, 2017
BACKGROUND:Nondepolarizing neuromuscular blocking drugs (NNMBDs) are commonly used as an adjunct to general anesthesia. Residual blockade is common, but its potential adverse effects are incompletely known. This study was designed to assess the association between NNMBD use with or without neostigmine reversal and postoperative morbidity and mortality ...
Michael P. Mangione +8 more
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BACKGROUND:Nondepolarizing neuromuscular blocking drugs (NNMBDs) are commonly used as an adjunct to general anesthesia. Residual blockade is common, but its potential adverse effects are incompletely known. This study was designed to assess the association between NNMBD use with or without neostigmine reversal and postoperative morbidity and mortality ...
Michael P. Mangione +8 more
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Journal of Cardiothoracic and Vascular Anesthesia, 2019
Nondepolarizing neuromuscular blocking agents (NMBAs) are associated with perioperative complications in noncardiac surgery; however, little is known about their effect on cardiac surgery. This study assessed the effect of neuromuscular blockade (NMB) on the incidence of postoperative pulmonary complications (PPCs) after cardiac surgery and operating ...
Rebecca M. Gerlach +8 more
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Nondepolarizing neuromuscular blocking agents (NMBAs) are associated with perioperative complications in noncardiac surgery; however, little is known about their effect on cardiac surgery. This study assessed the effect of neuromuscular blockade (NMB) on the incidence of postoperative pulmonary complications (PPCs) after cardiac surgery and operating ...
Rebecca M. Gerlach +8 more
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1993
Nondepolarizing neuromuscular blocking agents (NNMBAs) are frequently administered to patients in the intensive care unit (ICU). We conducted a retrospective study of patients in intensive care who received infusions (>48 hrs) of commonly used NNMBAs. The goals were to describe NNMBA use in our ICUs, determine patient characteristics, and assess the
Diann M. Clarens +5 more
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Nondepolarizing neuromuscular blocking agents (NNMBAs) are frequently administered to patients in the intensive care unit (ICU). We conducted a retrospective study of patients in intensive care who received infusions (>48 hrs) of commonly used NNMBAs. The goals were to describe NNMBA use in our ICUs, determine patient characteristics, and assess the
Diann M. Clarens +5 more
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Critical Care Medicine, 2000
Long-term treatment with nondepolarizing neuromuscular blocking agents and corticosteroids in the intensive care unit is not benign, and an increasing number of patients with acute quadriplegic myopathy have been reported with increased use of these drugs.
Stefano Schiaffino +6 more
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Long-term treatment with nondepolarizing neuromuscular blocking agents and corticosteroids in the intensive care unit is not benign, and an increasing number of patients with acute quadriplegic myopathy have been reported with increased use of these drugs.
Stefano Schiaffino +6 more
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1984
Vecuronium provides additional flexibility to the clinician using neuromuscular‐blocking drugs. Its shorter duration of action, lack of significant cardiovascular effects and lack of dependence on the kidney for elimination provide clinical advantages over, or alternatives to, currently available, nondepolarizing neuromuscular‐blocking drugs.
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Vecuronium provides additional flexibility to the clinician using neuromuscular‐blocking drugs. Its shorter duration of action, lack of significant cardiovascular effects and lack of dependence on the kidney for elimination provide clinical advantages over, or alternatives to, currently available, nondepolarizing neuromuscular‐blocking drugs.
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