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Neuromyelitis Optica Spectrum Disorder and Uveitis
Ocular Immunology and Inflammation, 2021Neuromyelitis Optica Spectrum Disorder (NMOSD) is a rare disease marked by CNS demyelination with a predilection for the optic nerve and spinal cord often resulting in severe vision loss. We aimed to characterize uveitis occurring in the setting of NMOSD.Retrospective chart review.Of 572 NMOSD patients, 1% were found to have uveitis with a relative ...
Andrew R, Carey, J Fernando, Arevalo
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Neuromyelitis Optica Spectrum Disorders
Continuum, 2016This article provides a practical approach for providers caring for patients with neuromyelitis optica (NMO) spectrum disorders. Clinical and imaging features, diagnostic criteria, treatment of acute exacerbations, chronic preventive therapy, and symptom management in NMO spectrum disorders are discussed.The rapid pace of research in NMO spectrum ...
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Pediatric Neuromyelitis Optica Spectrum Disorders
Current Treatment Options in Neurology, 2018Neuromyelitis optica spectrum disorders (NMOSDs) are a group of inflammatory and demyelinating disorders of the central nervous system that can occur in children and adults. The classic presentation of NMOSD is characterized by optic neuritis and transverse myelitis, but other presentations are also recognized, expanding the disease as NMO spectrum ...
Grace Y, Gombolay, Tanuja, Chitnis
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Neuromyelitis Optica Spectrum Disorders
Continuum, 2010Neuromyelitis optica is an uncommon inflammatory demyelinating CNS disorder that is distinct from multiple sclerosis with respect to clinical, laboratory, neuroimaging, and prognostic characteristics. Autoantibodies that target aquaporin-4 are highly specific for neuromyelitis optica and have helped define a spectrum of disease beyond the classic ...
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Immunobiology of neuromyelitis optica spectrum disorders
Current Opinion in Neurobiology, 2022Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune inflammatory disease of the central nervous system. Most of the cases are positive for autoantibodies targeting the water channel aquaporin-4 (AQP4-IgG). Activated B and T cells, innate immunity cells, pro-inflammatory cytokines, and activated complement contribute to the formation of ...
Daissy Liliana Mora Cuervo +2 more
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Neuromyelitis Optica Spectrum Disorders
2020Neuromyelitis optica spectrum disorders (NMOSD) are a heterogeneous group of inflammatory, demyelinating and antibody-mediated diseases of the central nervous system (CNS). The anti-aquaporin-4-IgG (AQP4-IgG) seems to be the pathogenetic agent, being present in the large majority of patients, although seronegative forms can occur.
Massimo Filippi, Maria A. Rocca
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Neuromyelitis optica spectrum disorder and menstruation
Revue Neurologique, 2018Gender issues and the female preponderance in neuromyelitis optica spectrum disorder (NMOSD) have been investigated before, yet the interplay between NMOSD and menstrual characteristics has remained unknown. Thus, the aim was to compare menstrual cycle patterns and their symptoms in NMOSD patients and healthy women.This cross-sectional study was ...
Shervin, Badihian +4 more
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Neuromyelitis optica spectrum disorder: pathophysiological approach
International Journal of Neuroscience, 2022Aim: To review the main pathological findings of Neuromyelitis Optica Spectrum Disorder (NMOSD) associated with the presence of autoantibodies to aquaporin-4 (AQP4) as well as the mechanisms of astrocyte dysfunction and demyelination. Methods: An comprehensive search of the literature in the field was carried out using the database of The National ...
Mario A. Mireles-Ramírez +7 more
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Neuromyelitis Optica Spectrum Disorder
2019Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, also known as Devic’s syndrome, that typically manifests with optic neuritis and transverse myelitis and, like other antibody-mediated autoimmune diseases, primarily affects women.
Samira Saadoun +2 more
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Infections in neuromyelitis optica spectrum disorder
Journal of Clinical Neuroscience, 2018Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory astrocytopathy that has both genetic and environmental causes. A growing body of evidence suggests that the presence of several infectious agents correlates with the development of NMOSD.
Zhong, X. +7 more
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