Results 21 to 30 of about 257,577 (143)
Cell Reports, 2016 In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss.
Christian M. Simon +5 more
doaj +1 more source
Molecular Brain, 2017 Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion.
Zhen Tian +4 more
doaj +1 more source
Error correction and fast detectors implemented by ultra-fast neuronal plasticity [PDF]
Phys. Rev. E 89, 042712 (2014), 2014 We experimentally show that the neuron functions as a precise time-integrator, where the accumulated changes in neuronal response latencies, under complex and random stimulation patterns, are solely a function of a global quantity, the average time-lag between stimulations.
arxiv +1 more source
Molecular Brain, 2020 Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control could have a major therapeutic impact for those ...
Matteo Manzati +3 more
doaj +1 more source
Nature Communications, 2023 Spinal muscular atrophy is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein Survival of Motor Neuron, or SMN.
Shaqraa Musawi +15 more
doaj +1 more source
Disease Models & Mechanisms, 2021 Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 protein ...
Katherine J. Robinson +7 more
doaj +1 more source
An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents
eLife, 2022 The respiratory system maintains homeostatic levels of oxygen (O2) and carbon dioxide (CO2) in the body through rapid and efficient regulation of breathing frequency and depth (tidal volume).
Mitchell Bishop +4 more
doaj +1 more source
Impact of adaptation currents on synchronization of coupled exponential integrate-and-fire neurons [PDF]
PLOS Computational Biology 8(4), e1002478 (2012), 2013 Author summary: Synchronization of neuronal spiking in the brain is related to cognitive functions, such as perception, attention, and memory. It is therefore important to determine which properties of neurons influence their collective behavior in a network and to understand how.
arxiv +1 more source
Neuron to Graph: Interpreting Language Model Neurons at Scale [PDF]
arXiv, 2023 Advances in Large Language Models (LLMs) have led to remarkable capabilities, yet their inner mechanisms remain largely unknown. To understand these models, we need to unravel the functions of individual neurons and their contribution to the network. This paper introduces a novel automated approach designed to scale interpretability techniques across a
arxiv
Single Biological Neurons as Temporally Precise Spatio-Temporal Pattern Recognizers [PDF]
arXiv, 2023 This PhD thesis is focused on the central idea that single neurons in the brain should be regarded as temporally precise and highly complex spatio-temporal pattern recognizers. This is opposed to the prevalent view of biological neurons as simple and mainly spatial pattern recognizers by most neuroscientists today.
arxiv