Results 21 to 30 of about 1,368,537 (360)
Molecular Brain, 2021 Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement.
Maxinne Watchon +12 more
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Intrinsic functional neuron-type selectivity of transcranial focused ultrasound neuromodulation
Nature Communications, 2021 Transcranial focused ultrasound (tFUS) is a promising neuromodulation technique, but its mechanisms remain unclear. We hypothesize that if tFUS parameters exhibit distinct modulation effects in different neuron populations, then the mechanism can be ...
Kai Yu +3 more
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Sex difference in synaptic plasticity in the anterior cingulate cortex of adult mice
Molecular Brain, 2020 Sex differences in certain types of pain sensitivity and emotional responses have been previously reported. Synaptic plasticity is a key cellular mechanism for pain perception and emotional regulation, including long-term potentiation (LTP) and long-term
Ren-Hao Liu +3 more
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Opinion: more mouse models and more translation needed for ALS
Molecular Neurodegeneration, 2023 Amyotrophic lateral sclerosis is a complex disorder most of which is ‘sporadic’ of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes.
Elizabeth M.C. Fisher +9 more
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Molecular Brain, 2023 Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and recent studies in the hippocampus found that LTP was impaired in aged animals. Previous studies of cortical LTP have focused primarily on the homosynaptic plasticity in
Si-Bo Zhou +9 more
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Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex
Molecular Brain, 2020 Anterior cingulate cortex (ACC) plays important roles in sensory perception including pain and itch. Neurons in the ACC receive various neuromodulatory inputs from subcortical structures, including locus coeruleus noradrenaline (LC-NA) neurons.
Kohei Koga +10 more
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Contagious itch can be induced in humans but not in rodents
Molecular Brain, 2019 Itch contagion has been reported in human when people watch someone scratching in a video. The basic mechanism of contagious itch induced by scratching video is still being investigated.
Jing-Shan Lu +7 more
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Journal of Neuroscience, 2006 Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of β-amyloid 42 (Aβ42) and cause familial Alzheimer's disease (FAD).
Holly Oakley +11 more
semanticscholar +1 more source
Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy
Cell Reports, 2017 The hallmark of spinal muscular atrophy (SMA), an inherited disease caused by ubiquitous deficiency in the SMN protein, is the selective degeneration of subsets of spinal motor neurons.
Christian M. Simon +10 more
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Journal of Neuroscience, 1982 The development of stimulus selectivity in the primary sensory cortex of higher vertebrates is considered in a general mathematical framework. A synaptic evolution scheme of a new kind is proposed in which incoming patterns rather than converging ...
E. Bienenstock, L. Cooper, P. Munro
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