Results 31 to 40 of about 635,756 (308)

Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3

open access: yesDisease Models & Mechanisms, 2021
Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 protein ...
Katherine J. Robinson   +7 more
doaj   +1 more source

Checkpoints for Parallel-Spiking-Neuron

open access: yes, 2023
https://github.com/fangwei123456/Parallel-Spiking ...
Wei Fang (9080993)
core   +1 more source

Characterization of serotonin-induced inhibition of excitatory synaptic transmission in the anterior cingulate cortex

open access: yesMolecular Brain, 2017
Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion.
Zhen Tian   +4 more
doaj   +1 more source

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom   +15 more
wiley   +1 more source

FedericoLeva/neuron-sensor_model: v1.0.2

open access: yes, 2021
<p>First release of the neuron-sensor model updated with datasets</p ...
Federico
core   +1 more source

Neuron Shapley: Discovering the Responsible Neurons

open access: yesCoRR, 2020
We develop Neuron Shapley as a new framework to quantify the contribution of individual neurons to the prediction and performance of a deep network. By accounting for interactions across neurons, Neuron Shapley is more effective in identifying important filters compared to common approaches based on activation patterns.
Amirata Ghorbani, James Y. Zou
openaire   +3 more sources

Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury [PDF]

open access: yesActa Neuropathologica Communications, 2015
Interneuronal propagation of α-synuclein has been demonstrated in a variety of experimental models and may be involved in disease progression during the course of human synucleinopathies. The aim of this study was to assess the role that neuronal injury or, vice versa, cell integrity could have in facilitating interneuronal α-synuclein transfer and ...
Ulusoy, Ayse   +6 more
openaire   +4 more sources

Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism

open access: yesActa Neuropathologica Communications
Dysregulation of the TAR DNA-binding protein 43 (TDP-43), including intraneuronal cytoplasmic mislocalisation and aggregation is a feature of multiple neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia
Alison L. Hogan   +11 more
doaj   +1 more source

Human iPSC co-culture model to investigate the interaction between microglia and motor neurons

open access: yesScientific Reports, 2022
Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor neuron degeneration with additional involvement of non-neuronal cells, in particular, microglia.
Björn F. Vahsen   +13 more
doaj   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy