Results 31 to 40 of about 585,120 (318)

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Nature Communications, 2023
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia.
Björn F. Vahsen, Sumedha Nalluru, Georgia R. Morgan, Lucy Farrimond, Emily Carroll, Yinyan Xu, Kaitlyn M. L. Cramb, Benazir Amein, Jakub Scaber, Antigoni Katsikoudi, Ana Candalija, Mireia Carcolé, Ruxandra Dafinca, Adrian M. Isaacs, Richard Wade-Martins, Elizabeth Gray, Martin R. Turner, Sally A. Cowley, Kevin Talbot   +18 more
doaj   +1 more source

A Stem Cell Model of the Motor Circuit Uncouples Motor Neuron Death from Hyperexcitability Induced by SMN Deficiency

Cell Reports, 2016
In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss.
Christian M. Simon, Anna M. Janas, Francesco Lotti, Juan Carlos Tapia, Livio Pellizzoni, George Z. Mentis   +5 more
doaj   +1 more source

International data governance for neuroscience [PDF]

, 2021
open access article This paper was produced by the International Brain Initiative Data Standards and Sharing Working Group's Taskforce on International Data Governance chaired by Damian Eke (from CCSR)As neuroscience projects increase in scale and ...
Ricardo Chavarriaga, Chavarriaga, Ricardo, Bjaalie, Jan G., Damian Eke, Franco Pestilli, McMahon, Agnes, Anthony Hannan, Jan G. Bjaalie, Hanakawa, Takashi, Hill, Sean L., Thiels, Edda, Crook, Sharon, Eke, Damian O, Hill, Sean L, McMahon, Anges, Hannan, Anthony J., Hannan, Anthony J, Martone, Maryann E, Eke, Damian, Bjaalie, Jan G, Eke, Damian O., Sharon Crook, Sean Hill, Martone, Maryann E., Pestilli, Franco, Amy Bernard, Bjaalie, G. Jan, Ruebel, Oliver, Agnes McMahon, Maryann Elizabeth Martone, Reubel, Oliver, Takashi Hanakawa, Edda Thiels, Eke, Damian Okaibedi, Oliver Ruebel, Bernard, Amy   +35 more
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Foetal neural progenitors contribute to postnatal circuits formation ex vivo: an electrophysiological investigation

Molecular Brain, 2020
Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control could have a major therapeutic impact for those ...
Matteo Manzati, Teresa Sorbo, Michele Giugliano, Laura Ballerini   +3 more
doaj   +1 more source

Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments

Nature Communications, 2023
Spinal muscular atrophy is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein Survival of Motor Neuron, or SMN.
Shaqraa Musawi, Lise-Marie Donnio, Zehui Zhao, Charlène Magnani, Phoebe Rassinoux, Olivier Binda, Jianbo Huang, Arnaud Jacquier, Laurent Coudert, Patrick Lomonte, Cécile Martinat, Laurent Schaeffer, Denis Mottet, Jocelyn Côté, Pierre-Olivier Mari, Giuseppina Giglia-Mari   +15 more
doaj   +1 more source

Neuron Merging: Compensating for Pruned Neurons

CoRR, 2020
NeurIPS ...
Woojeong Kim, Suhyun Kim 0001, Mincheol Park, Geunseok Jeon   +3 more
openaire   +3 more sources

Predicting olfactory receptor neuron responses from odorant structure [PDF]

, 2007
Background Olfactory receptors work at the interface between the chemical world of volatile molecules and the perception of scent in the brain. Their main purpose is to translate chemical space into information that can be processed by neural circuits ...
De Bruyne, Marien, de Bruyne Marien, Melanie Hähnel (16193975), Marien de Bruyne (170456), Hähnel, Melanie, Michael Schmuker (4736406), Schmuker Michael, Schneider, Gisbert (Prof. Dr.), Schmuker, Michael, Gisbert Schneider (17096), Hähnel Melanie, Schneider Gisbert   +11 more
core   +1 more source

FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA [PDF]

, 2012
Mutations in the RNA binding protein FUS cause amyotrophic lateral sclerosis (ALS), a fatal adult motor neuron disease. Decreased expression of SMN causes the fatal childhood motor neuron disorder spinal muscular atrophy (SMA).
Das, Rita, Maniatis, Tom, Sharma, A, Yan, Biao, Tapia, JC, Gygi, Steve P., Monica A. Carrasco, Shneider, NA, Nishimura, AL, Chen, Shi, Yu, Yong, Sharma, Aarti, Yan, B, Gygi, SP, Christopher E. Shaw, Yamazaki, T, Steve P. Gygi, Siddharthan Chandran, Reed, Robin, Yu, Y, Aarti Sharma, Reed, R, Yong Yu, Rita Das, Das, R, Carrasco, Monica A., Zhai, Bo, Shneider, Neil A., Chen, S, Juan C. Tapia, Tapia, Juan C., Agnes Lumi Nishimura, Lalancette-Hebert, Melanie, Haertlein, TC, Tom Maniatis, Lalancette-Hebert, M, Biao Yan, Carrasco, MA, Neil A. Shneider, Yamazaki, Tomohiro, Nishimura, Agnes Lumi, Sullivan, G, Maniatis, T, Shaw, Christopher E., Shi Chen, Zhai, B, Melanie Lalancette-Hebert, Sullivan, Gareth, Tyler C. Haertlein, Shaw, CE, Chandran, S, Haertlein, Tyler C., Tomohiro Yamazaki, Gareth Sullivan, Robin Reed, Bo Zhai, Chandran, Siddharthan   +56 more
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Neuron-level Interpretation of Deep NLP Models: A Survey [PDF]

, 2022
The proliferation of Deep Neural Networks in various domains has seen an increased need for interpretability of these models. Preliminary work done along this line, and papers that surveyed such, are focused on high-level representation analysis. However,
Nadir Durrani (5297438), Fahim Dalvi, Hassan Sajjad (5297441), Fahim Dalvi (18427905), Hassan Sajjad, Nadir Durrani   +5 more
core   +1 more source

Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease

Molecular Brain, 2021
Parkinson’s disease (PD) is a multi-system neurodegenerative disorder. Patients with PD often suffer chronic pain. In the present study, we investigated motor, sensory and emotional changes in three different PD mice models.
Zhaoxiang Zhou, Penghai Ye, Xu-Hui Li, Yuxiang Zhang, Muhang Li, Qi-Yu Chen, Jing-Shan Lu, Man Xue, Yanan Li, Weiqi Liu, Lin Lu, Wantong Shi, Ping-Yi Xu, Min Zhuo   +13 more
doaj   +1 more source