Results 21 to 30 of about 1,014,356 (296)
Timing Control of Single Neuron Spikes with Optogenetic Stimulation [PDF]
, 2018 This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron'
Eckford, Andrew W. +3 more
core +2 more sources
Nature Communications, 2022 Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.
Alexis Osseni +10 more
doaj +1 more source
Why Neurons Have Thousands of Synapses, A Theory of Sequence Memory in Neocortex [PDF]
, 2015 Neocortical neurons have thousands of excitatory synapses. It is a mystery how neurons integrate the input from so many synapses and what kind of large-scale network behavior this enables.
Ahmad, Subutai, Hawkins, Jeff
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Microvascular decompression for hemifacial spasm: a review of twenty-one operated cases
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2020 Background Microvascular decompression of facial nerve provides definitive and long-term cure for hemifacial spasm. We review our experience of treating hemifacial spasm by microvascular decompression.
Amey P. Patankar
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Development, 2015 Neurons are highly polarized cells with structurally and functionally distinct processes called axons and dendrites. This polarization underlies the directional flow of information in the central nervous system, so the establishment and maintenance of neuronal polarization is crucial for correct development and function.
Tetsuya, Takano +4 more
openaire +2 more sources
Cell Reports, 2016 In spinal muscular atrophy, a neurodegenerative disease caused by ubiquitous deficiency in the survival motor neuron (SMN) protein, sensory-motor synaptic dysfunction and increased excitability precede motor neuron (MN) loss.
Christian M. Simon +5 more
doaj +1 more source
Nature Communications, 2023 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, with additional pathophysiological involvement of non-neuronal cells such as microglia.
Björn F. Vahsen +18 more
doaj +1 more source
Molecular Brain, 2020 Neuronal progenitor cells (NPC) play an essential role in homeostasis of the central nervous system (CNS). Considering their ability to differentiate into specific lineages, their manipulation and control could have a major therapeutic impact for those ...
Matteo Manzati +3 more
doaj +1 more source
Neurons other than motor neurons in motor neuron disease.
Histology and histopathology, 2017 Amyotrophic lateral sclerosis (ALS) is typically defined by a loss of motor neurons in the central nervous system. Accordingly, morphological analysis for decades considered motor neurons (in the cortex, brainstem and spinal cord) as the neuronal population selectively involved in ALS.
Ruffoli R +7 more
openaire +5 more sources
Finite element modeling of the neuron-electrode interface: stimulus transfer and geometry [PDF]
, 1999 The relation between stimulus transfer and the geometry of the neuron-electrode interface can not be determined properly using electrical equivalent circuits, since current that flows from the sealing gap through the neuronal membrane is difficult to ...
Buitenweg, J.R. +2 more
core +3 more sources