Results 41 to 50 of about 585,120 (318)
Neuron-specific Edis depletion leads to hyperactivation of innate immunity. [PDF]
, 2022 The UAS-shEdis or control UAS-shGFP flies were crossed to the neuron-specific Elav-Gal4 driver line. Levels of the circRNA Edis or the Dpt mRNA in male or female fly head samples were measured (student t test, n = 3, * ppp (TIF)
Shiyu Xu (9662931) +11 more
core +1 more source
Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
Scientific Reports, 2022 Motor neuron diseases such as amyotrophic lateral sclerosis are primarily characterized by motor neuron degeneration with additional involvement of non-neuronal cells, in particular, microglia.
Björn F. Vahsen +13 more
doaj +1 more source
Molecular Brain, 2017 Excitatory synaptic transmission in central synapses is modulated by serotonin (5-HT). The anterior cingulate cortex (ACC) is an important cortical region for pain perception and emotion.
Zhen Tian +4 more
doaj +1 more source
Disease Models & Mechanisms, 2021 Spinocerebellar ataxia 3 (SCA3, also known as Machado–Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 protein ...
Katherine J. Robinson +7 more
doaj +1 more source
Modulation of Neuronal Interactions Through Neuronal Synchronization [PDF]
Science, 2007 Brain processing depends on the interactions between neuronal groups. Those interactions are governed by the pattern of anatomical connections and by yet unknown mechanisms that modulate the effective strength of a given connection. We found that the mutual influence among neuronal groups depends on the phase relation between rhythmic activities within
Womelsdorf, T. +6 more
openaire +4 more sources
Neuron-specific Edis depletion using a second shRNA transgene leads to innate immunity hyperactivation and MB morphology phenotypes. [PDF]
, 2022 (A) Control UAS-shgfp or UAS-shEdis-B flies were crossed to the neuron-specific Elav-Gal4 driver animals. Total RNA samples were prepared from fly heads of the indicated genotypes. Levels of the Edis, Ect4 and Dpt transcripts were measured and normalized
Shiyu Xu (9662931) +11 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Acta Neuropathologica CommunicationsDysregulation of the TAR DNA-binding protein 43 (TDP-43), including intraneuronal cytoplasmic mislocalisation and aggregation is a feature of multiple neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar dementia
Alison L. Hogan +11 more
doaj +1 more source
Neuron Shapley: Discovering the Responsible Neurons
CoRR, 2020 We develop Neuron Shapley as a new framework to quantify the contribution of individual neurons to the prediction and performance of a deep network. By accounting for interactions across neurons, Neuron Shapley is more effective in identifying important filters compared to common approaches based on activation patterns.
Amirata Ghorbani, James Y. Zou
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source