Results 81 to 90 of about 1,209,467 (344)

Spin-Based Neuron Model with Domain Wall Magnets as Synapse

, 2012
We present artificial neural network design using spin devices that achieves ultra low voltage operation, low power consumption, high speed, and high integration density.
Augustine, Charles, Panagopoulos, Georgios, Roy, Kaushik, Sharad, Mrigank   +3 more
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Ion Concentration Dynamics as a Mechanism for Neuronal Bursting

, 2011
We describe a simple conductance-based model neuron that includes intra- and extra-cellular ion concentration dynamics and show that this model exhibits periodic bursting. The bursting arises as the fast spiking behavior of the neuron is modulated by the
Barreto, Ernest, Cressman, John R.
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

Nature Communications, 2016
The mechanism by which FUS mutations cause familial ALS remains unclear. Here, the authors use mouse transgenic models to show that a toxic gain-of-function underlies motor neuron degeneration, and that the toxicity of mutant FUS does not depend on a ...
Aarti Sharma, Alexander K. Lyashchenko, Lei Lu, Sara Ebrahimi Nasrabady, Margot Elmaleh, Monica Mendelsohn, Adriana Nemes, Juan Carlos Tapia, George Z. Mentis, Neil A. Shneider   +9 more
doaj   +1 more source

Neuron dynamics in the presence of 1/f noise

, 2011
Interest in understanding the interplay between noise and the response of a non-linear device cuts across disciplinary boundaries. It is as relevant for unmasking the dynamics of neurons in noisy environments as it is for designing reliable nanoscale ...
A. L. Hodgkin, Arif Babul, C. Koch, Cameron Sobie, G. Svirskis, J. M. Hausdorff, J. Timmer, L. Lapicque, Rogério de Sousa, Sh. Kogan, W. H. Press   +10 more
core   +1 more source

Super Neurons

IEEE Transactions on Emerging Topics in Computational Intelligence
Self-Organized Operational Neural Networks (Self-ONNs) have recently been proposed as new-generation neural network models with nonlinear learning units, i.e., the generative neurons that yield an elegant level of diversity; however, like its predecessor, conventional Convolutional Neural Networks (CNNs), they still have a common drawback: localized ...
Serkan Kiranyaz, Junaid Malik, Mehmet Yamac, Mert Duman, Ilke Adalioglu, Esin Guldogan, Turker Ince, Moncef Gabbouj   +7 more
openaire   +4 more sources

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Cyclin F can alter the turnover of TDP-43

Neurobiology of Disease
Previously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43.
Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Tyler Chapman, Flora Cheng, Luan Luu, Sharlynn Wu, Selina Zhang, Shu Yang, Ian Blair, Marco Morsch, Roger Chung, Albert Lee   +12 more
doaj   +1 more source

Energy efficiency of information transmission by electrically coupled neurons

, 2012
The generation of spikes by neurons is energetically a costly process. This paper studies the consumption of energy and the information entropy in the signalling activity of a model neuron both when it is supposed isolated and when it is coupled to ...
Abarbanel, Abdelmalik Moujahid, Alicia d’Anjou, Attwell, Balasubramanian, Belykh, Cecilia Sarasola, Clarke, Connors, Dhamala, Donald, FitzHugh, Francisco J. Torrealdea, Galarreta, Hansel, Hasegawa, Hayashi, Herz, Hindmarsh, Hodgkin, Huerta, Kasischke, Kepler, Koch, Kolb, Lago-Fernandez, Laughlin, Lennie, Levy, Levy, Mackay, Morrison, N. Vélez de Mendizábal, Nagai, Nemenman, Olver, Ozden, Pinto, Rieke, Rose, Rose, Rose, Rose, Rosenblum, Roy, Rulkov, Sarasola, Schreiber, Selverston, Shannon, Siekevitz, Smith, Strong, Torrealdea, Torrealdea, Venaille, Veruki, Veruki, Vincent, Wu, Yoshioka   +60 more
core   +1 more source