Results 71 to 80 of about 585,120 (318)
The era of cryptic exons: implications for ALS-FTD
Molecular Neurodegeneration, 2023 TDP-43 is an RNA-binding protein with a crucial nuclear role in splicing, and mislocalises from the nucleus to the cytoplasm in a range of neurodegenerative disorders.
Puja R. Mehta +3 more
doaj +1 more source
I, NEURON: the neuron as the collective [PDF]
Kybernetes, 2017 Purpose In the last half-century, individual sensory neurons have been bestowed with characteristics of the whole human being, such as behavior and its oft-presumed precursor, consciousness. This anthropomorphization is pervasive in the literature. It is also absurd, given what we know about neurons, and it needs to be abolished.
openaire +1 more source
Firing proprieties of an adaptive analog VLSI neuron [PDF]
, 2004 Ben Dayan Rubin D, Chicca E, Indiveri G. Firing proprieties of an adaptive analog VLSI neuron. Presented at the Proceedings of Bio-ADIT, Lausanne, Switzerland.We describe the response properties of a compact, low power, analog circuit that implements a ...
Ben Dayan Rubin, D. +2 more
core +1 more source
Decoding the molecular mechanism underpinning motor neuron degeneration in ALS [PDF]
, 2023 reservedMotor neuron degeneration is one of the main feature of different neuromuscular diseases, including Amyotrophic Lateral Sclerosis (ALS). The molecular mechanism underpinning motor neuron degeneration has not been well understood yet, hampering ...
SARTORE, LUIGI
core
Neuron-specific Edis depletion leads to hyperactivation of innate immunity, impaired locomotion and shortened lifespan. [PDF]
, 2022 (A) The UAS-Edis or control UAS-empty vector transgenic flies were crossed to the Elav-Gal4 driver line. Total RNA was prepared from dissected fly heads, and levels of the circular Edis RNA or Dpt mRNA were measured (student t test, n = 3, * ppB) The UAS-
Shiyu Xu (9662931) +11 more
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The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Spermidine treatment: induction of autophagy but also apoptosis?
Molecular BrainMachado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis.
Maxinne Watchon +7 more
doaj +1 more source
Redox Biology, 2018 Generation of reactive oxygen species (ROS) has been shown to be important for many physiological processes, ranging from cell differentiation to apoptosis. With the development of the genetically encoded photosensitiser KillerRed (KR) it is now possible
Isabel Formella +8 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
, 2010 "My research project is about Parkinson’s disease, and creating an interactive Adobe Flash® module designed to help those newly diagnosed and their loved ones understand the disease.
Eric Small (4907719)
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