Results 91 to 100 of about 585,120 (318)
Neurological Research and PracticeObjective Robotic arms are innovative assistive devices for ALS patients with progressive motor deficits of arms and hands. The objective was to explore the patients´ expectations towards a robotic arm system and to assess the actual experiences after ...
Susanne Spittel +18 more
doaj +1 more source
Mode locking in a periodically forced "ghostbursting" neuron model [PDF]
, 2004 We study a minimal integrate-and-fire based model of a "ghostbursting" neuron under periodic stimulation. These neurons are involved in sensory processing in weakly electric fish.
Laing, Carlo +2 more
core +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Cell Reports, 2013 Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by a deficiency in the survival motor neuron (SMN) protein. SMN mediates the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs) and possibly other RNPs.
Sarah Tisdale +7 more
doaj +1 more source
A VLSI-design of the minimum entropy neuron [PDF]
, 2010 One of the most interesting domains of feedforward networks is the processing of sensor signals. There do exist some networks which extract most of the information by implementing the maximum entropy principle for Gaussian sources.
Brause, Rüdiger W.
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
On the excitation and inhibition of the inspiratory neuron in the respiratory centers [PDF]
, 1956 In decerebrated cats the impulse discharges were detected by means of an unipolar microelectrode from a single inspiratory neuron in the respiratory centers, and the change in discharge produced by administration of stimulating, as well as depressant ...
Hukuhara, Takesi, Okada, Hiromasa
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Extracting non-linear integrate-and-fire models from experimental data using dynamic I–V curves [PDF]
, 2008 The dynamic I–V curve method was recently introduced for the efficient experimental generation of reduced neuron models. The method extracts the response properties of a neuron while it is subject to a naturalistic stimulus that mimics in vivo-like ...
Wulfram Gerstner +11 more
core +1 more source