Results 71 to 80 of about 5,245,598 (349)

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein [PDF]

Proceedings of the National Academy of Sciences, 2009
Neuronal accumulation of α-synuclein and Lewy body formation are characteristic to many neurodegenerative diseases, including Parkinson's disease (PD). This Lewy pathology appears to spread throughout the brain as the disease progresses. Furthermore, recent studies showed the occurrence of Lewy pathology in neurons grafted into the brains of PD ...
Paula, Desplats, He-Jin, Lee, Eun-Jin, Bae, Christina, Patrick, Edward, Rockenstein, Leslie, Crews, Brian, Spencer, Eliezer, Masliah, Seung-Jae, Lee   +8 more
openaire   +2 more sources

How Reliably Does a Neuron in the Visual Motion Pathway of fhe Fly Encode Behaviourally Relevant Information? [PDF]

, 1997
Warzecha A-K, Egelhaaf M. How Reliably Does a Neuron in the Visual Motion Pathway of fhe Fly Encode Behaviourally Relevant Information? European Journal of Neuroscience. 1997;9(7):1365-1374.How reliably neurons convey information depends on the extent to
Egelhaaf, Martin ; https://orcid.org/, Martin Egelhaaf, Anne‐Kathrin Warzecha, Warzecha, Anne-Kathrin   +3 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Behavioral Simulation of Biological Neuron Systems in SystemC

, 2004
The investigation of neuron structures is an incredibly difficult and complex task that yields relatively low rewards in terms of information from biological forms (either animals or tissue).
Brown, Andrew D., Wilson, Peter R., Modi, Sankalp, Chad, John E.   +3 more
core   +1 more source

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

Frontiers in Physiology, 2019
The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes.
Susan Yu. Gordleeva, Anastasia V. Ermolaeva, Innokentiy A. Kastalskiy, Victor B. Kazantsev   +3 more
doaj   +1 more source

Neuron‐to‐neuron transmission of α‐synuclein fibrils through axonal transport [PDF]

Annals of Neurology, 2012
Abstract Objective: The lesions of Parkinson disease spread through the brain in a characteristic pattern that corresponds to axonal projections. Previous observations suggest that misfolded α‐synuclein could behave as a prion, moving from neuron to neuron and causing endogenous α‐synuclein to ...
Eric C, Freundt, Nate, Maynard, Eileen K, Clancy, Shyamali, Roy, Luc, Bousset, Yannick, Sourigues, Markus, Covert, Ronald, Melki, Karla, Kirkegaard, Michel, Brahic   +9 more
openaire   +2 more sources

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Coupling of Semiconductor Nanowires with Neurons and Their Interfacial Structure

Nanoscale Research Letters, 2009
We report on the compatibility of various nanowires with hippocampal neurons and the structural study of the neuron–nanowire interface. Si, Ge, SiGe, and GaN nanowires are compatible with hippocampal neurons due to their native oxide, but ZnO ...
Rhim Hyewhon, Kim Sunoh, Park Seung-Han, Ahn Jae-Pyeong, Lee Ki-Young, Shim Sojung, Kim Il-Soo, Oh Hwangyou, Choi Heon-Jin   +8 more
doaj   +1 more source

Adaptation and selective information transmission in the cricket auditory neuron AN2. [PDF]

PLoS Computational Biology, 2008
Sensory systems adapt their neural code to changes in the sensory environment, often on multiple time scales. Here, we report a new form of adaptation in a first-order auditory interneuron (AN2) of crickets. We characterize the response of the AN2 neuron
Klaus Wimmer, K Jannis Hildebrandt, R Matthias Hennig, Klaus Obermayer   +3 more
doaj   +1 more source

Precise timing in fly motion vision is mediated by fast components of combined graded and spike signals [PDF]

, 2009
Beckers U, Egelhaaf M, Kurtz R. Precise timing in fly motion vision is mediated by fast components of combined graded and spike signals. Neuroscience.
Beckers, U., Egelhaaf, Martin ; https://orcid.org/, Kurtz, Rafael   +2 more
core   +1 more source