Results 81 to 90 of about 1,037,185 (302)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Impact of Neuro-Behcet Disease Immunoglobulin G on Neuronal Apoptosis

, 2017
Introduction: Parenchymal neuro-Behcet disease (NBD) is encountered in 5%-15% of Behcet disease (BD) patients and is characterized by inflammation of the brainstem and diencephalon structures.
Bireller, Sinem, Hanagasi, Haşmet Ayhan, Hanagasi, Hasmet, Degirmencioglu, Sevgin, Kucukali, Cem Ismail, Tuzun, Erdem, Giris, Murat   +6 more
core   +1 more source

Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain [PDF]

, 2005
It has been proposed that death of inhibitory interneurons in the dorsal horn contributes to the neuropathic pain that follows partial nerve injury. In this study, we have used two approaches to test whether there is neuronal death in the dorsal horn in ...
Polgar, Erika, Todd, A.J., Arham, A.Z., Hughes, D.I.   +3 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

PARP9 exacerbates apoptosis and neuroinflammation via the PI3K pathway in the thalamus and hippocampus and cognitive decline after cortical infarction

Journal of Neuroinflammation
Background Cerebral infarction induces substantial neuronal apoptosis and neuroinflammation in the ipsilateral nonischemic thalamus and hippocampus, with a critical correlation to post-stroke cognitive impairment.
Mengshi Liao, Xiya Long, Yicong Chen, Jiaqi An, Weixian Huang, Xiangming Xu, Yuhua Fan   +6 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Imipramine, an Acid Sphingomyelinase Inhibitor, Promotes Newborn Neuron Survival in the Hippocampus After Seizure

Cells
Epilepsy, a chronic neurological disorder, is triggered by various insults, including traumatic brain injury and stroke. Acid sphingomyelinase (ASMase), an enzyme that hydrolyzes sphingomyelin into ceramides, is implicated in oxidative stress ...
Song Hee Lee, Hyun Wook Yang, Beom Seok Kang, Min Kyu Park, Dong Yeon Kim, Hong Ki Song, Hui Chul Choi, Minwoo Lee, Bo Young Choi, Dae-Soon Son, Sang Won Suh   +10 more
doaj   +1 more source

Neuronal apoptosis in the brains of focal cerebral ischemia/reperfusion rats as shown by TUNEL assay.

, 2016
A, B, C, D, E, and F represent the sham group, the VT group, the rLj-RGD3 100.0 μg·kg-1 group, the rLj-RGD3 50.0 μg·kg-1 group, the Edaravone 1.5 mg·kg-1 group, and the Eptifibatide 100.0 μg·kg-1 group, respectively.
Yue Wang (65477), Weiping Li (43906), Shengnan Wang (398641), Jihong Wang (2077267), Li Lv (382638), Qingwei Li (168118), Qian Lu (387695), Qilan Jia (3234489), Qin Zhou (239082), Junshu Jiang (3234486)   +9 more
core   +1 more source

METTL14 promotes apoptosis of spinal cord neurons by inducing EEF1A2 m6A methylation in spinal cord injury

Cell Death Discovery, 2022
Spinal cord injury (SCI) is a devastating traumatic condition. METTL14-mediated m6A modification is associated with SCI. This study was intended to investigate the functional mechanism of RNA methyltransferase METTL14 in spinal cord neuron apoptosis ...
Gang Gao, Yufen Duan, Feng Chang, Ting Zhang, Xinhu Huang, Chen Yu   +5 more
doaj   +1 more source

miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis [PDF]

, 2011
The execution of apoptosis is critical for proper development of the nervous system. However, it is equally important that neurons strictly inhibit apoptosis after development to ensure their survival throughout the lifetime of the organism. Here we show
Kole, A. J., Deshmukh, M., Hammond, S. M., Adam J. Kole, Scott M. Hammond, Swahari, V., Mohanish Deshmukh, Vijay Swahari   +7 more
core   +1 more source