Neuronal-epithelial cell fusion involved mixed bundles of fusing and penetrating axons.
, 2019 Four examples of neuronal-epithelial cell fusion (A-D). The electron translucent portion of each nerve bundle (*) was fused with a basal epithelial cell.
Ian Smith (20961) +9 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Effects of aging on nitrergic system in human basal nuclei
Arquivos de Neuro-Psiquiatria, 2014 Nitric oxide (NO) is a gaseous molecule that plays a role in a number of physiologic processes. The available evidence suggests that NO is a major neurotransmitter involved in motor control and emotion/behavior modulation. To investigate the distribution
Bruno Lopes dos Santos
doaj +1 more source
Reporting whole-body vibration intervention studies: Recommendations of the International Society of Musculoskeletal and Neuronal Interactions [PDF]
, 2010 Whole-body vibration (WBV) is receiving increasing interest as a therapeutic modality to improve neuromuscular performance or to increase bone mass or density. In order to help improve the quality of reports about WBV treatment studies, the International
Sievänen, Harrir +19 more
core
Neuronal avalanches differ from wakefulness to deep sleep - evidence from intracranial depth recordings in humans [PDF]
, 2013 Neuronal activity differs between wakefulness and sleep states. In contrast, an attractor state, called self-organized critical (SOC), was proposed to govern brain dynamics because it allows for optimal information coding.
Viola Priesemann +15 more
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Induced neuronal activity does not attenuate amyloid beta‐induced synaptic loss in vitro
Neuropsychopharmacology Reports, 2019 Aim The accumulation of amyloid beta (Aβ) is one of the characteristics of Alzheimer's disease. The excessive accumulation of Aβ has been suggested to result in a decrease in the number of synapses.
Rena Kono +4 more
doaj +1 more source
Neuronal actin dynamics, spine density and neuronal dendritic complexity are regulated by CAP2
Frontiers in Cellular Neuroscience, 2016 Actin remodeling is crucial for dendritic spine development, morphology and density. CAP2 is a regulator of actin dynamics through sequestering G-actin and severing F-actin.
Atul Kumar +5 more
doaj +1 more source
SIRT3 activation promotes enteric neurons survival and differentiation
Scientific Reports, 2022 Enteric neuron degeneration has been observed during aging, and in individuals with metabolic dysfunction including obesity and diabetes. Honokiol, a naturally occurring compound, is an activator of Sirtuin-3 (SIRT3) that has antioxidant activity.
Arun Balasubramaniam +6 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source