Results 51 to 60 of about 3,802,907 (250)

Constraints of Metabolic Energy on the Number of Synaptic Connections of Neurons and the Density of Neuronal Networks

Frontiers in Computational Neuroscience, 2018
Neuronal networks in the brain are the structural basis of human cognitive function, and the plasticity of neuronal networks is thought to be the principal neural mechanism underlying learning and memory. Dominated by the Hebbian theory, researchers have
Ye Yuan, Ye Yuan, Hong Huo, Hong Huo, Peng Zhao, Peng Zhao, Jian Liu, Jian Liu, Jiaxing Liu, Jiaxing Liu, Fu Xing, Fu Xing, Tao Fang, Tao Fang   +13 more
doaj   +1 more source

Motivations and APS-based solution for high-resolution extracellular recording from in-vitro neuronal networks [PDF]

Mapping neuronal networks activity of in-vitro cell cultures with microelectrode array (MEA) based systems, providing a spatial resolution down to cellular/sub-cellular levels and an adequate temporal resolution for resolving action potential propagation
Martinoia, Sergio, Garenne, André, Imfeld, Kilian, Berdondini, Luca, Koudelka-Hep, Milena   +4 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Protein malnutrition during gestation and early life decreases neuronal size in the medial prefrontal cortex of post-pubertal rats

IBRO Reports, 2017
Retrospective studies in human populations indicate that protein deprivation during pregnancy and early life (early protein malnutrition, EPM) is associated with cognitive impairments, learning disabilities and may represent a risk factor for the late ...
Roelf J. Cruz-Rizzolo, Laís Leal Limieri, Isabela Rogério de Paiva, Jéssica O. Barbosa Ribeiro, Taís Fernandes Pimenta, Luciana Pinato, Edilson Ervolino, Cláudio Aparecido Casatti, Leila M. Guissoni Campos, Edson Aparecido Liberti   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Interferon-γ induced nitric oxide mediates in vitro neuronal damage by Trypanosoma cruzi-infected macrophages

Neurobiology of Disease, 2007
Neuronal lesions and peripheral denervation in Chagas' disease are related to local inflammation; however, the pathogenic mechanisms of neuronal lesions in the heart and megavisceras are still unclear. We investigated the involvement of nitric oxide (NO)
Camila Megale de Almeida-Leite, Lúcia Maria da Cunha Galvão, Luis C.C. Afonso, Fernando de Queiróz Cunha, Rosa Maria Esteves Arantes   +4 more
doaj   +1 more source

The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons

Frontiers in Neuroscience, 2023
The lysosomal protein TMEM106B was identified as a risk modifier of multiple dementias including frontotemporal dementia and Alzheimer’s disease. The gene comes in two major haplotypes, one associated with disease risk, and by comparison, the other with ...
Quynh Nguyen, Caleb A. Wood, Peter J. Kim, Joanna L. Jankowsky, Joanna L. Jankowsky   +4 more
doaj   +1 more source

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique, Philippe Bertrand, Bégard, Séverine, Luc Buée, André Delacourte, Séverine Bégard, Bertrand, Philippe, Hamdane, Malika, Katharina Schindowski, Bretteville, Alexis, Anne-Véronique Sambo, Schindowski, Katharina, Delacourte, André, Buée, Luc, Malika Hamdane, Alexis Bretteville   +15 more
core   +1 more source

Astrocyte-neuronal network interplay is disrupted in Alzheimers disease mice [PDF]

, 2022
Alzheimers disease (AD) is associated with senile plaques of beta-amyloid (Aß) that affect the function of neurons and astrocytes. Brain activity results from the coordinated function of neurons and astrocytes in astroglial-neuronal networks.
Aguilar Lepe, Juan de los Reyes
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source