Results 81 to 90 of about 3,802,907 (250)

Neuronal and astroglial correlates underlying spatiotemporal Intrinsic Optical Signal in the rat hippocampal slice [PDF]

, 2013
Widely used for mapping afferent activated brain areas in vivo, the label-free intrinsic optical signal (IOS) is mainly ascribed to blood volume changes subsequent to glial glutamate uptake.
Ildikó Pál, László Héja (370338), László Héja, Gabriella Nyitrai (370339), Héja, László, Julianna Kardos, Ildikó Pál (384561), Kardos, Julianna, Nyitrai, Gabriella, Gabriella Nyitrai, Julianna Kardos (370347), Pál, Ildikó, Pál Ildikó, Kardos Julianna, Héja László, Nyitrai Gabriella   +15 more
core   +2 more sources

Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control

, 2005
The precise assembly of neuronal circuits requires that the correct number of pre- and postsynaptic neurons form synaptic connections. Neuronal cell number is thus tightly controlled by cell death during development.
NOVELLI E, GALLI RESTA L., DI VIRGILIO, Francesco, RESTA V, Di Virgilio F, Vozzi G, Santini E, Caleo M, Solini A, GalliResta L, Parisi V, Ahluwalia A, Scarpa C, Francesco Di Virgilio, Lucia Galli-Resta, Elena Novelli, Valentina Resta   +16 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Novel insights into early Alzheimer's disease: quantitative gradient recalled echo MRI reveals preatrophic neuronal and myelin injury concurrent with emerging amyloid pathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
BACKGROUND Brain amyloid accumulation is considered an early sign of Alzheimer's disease (AD) pathology, appearing decades before manifestation of clinical symptoms. However, very little is known about neurodegeneration during this early AD stage. Herein
Satya V. V. N. Kothapalli, Tammie L. S. Benzinger, Randall J. Bateman, Melody Li, Cihat Eldeniz, John C. Morris, Dmitriy A. Yablonskiy   +6 more
doaj   +1 more source

Spatial Analysis of the Neuronal Density of Aminergic Brainstem Nuclei in Primary Neurodegenerative and Vascular Dementia: A Comparative Immunocytochemical and Quantitative Study Using a Graph Method

Analytical Cellular Pathology, 1999
A graph method was employed to analyse spatial neuronal patterns of pontine nuclei with ascending aminergic projections to the forebrain (nucleus centralis superior (NCS), raphes dorsalis (NRD) and locus coeruleus (LC)), in Alzheimer disease (AD ...
Yan Yang, Konrad Beyreuther, Horst P. Schmitt   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effects of aging on nitrergic neurons in human striatum and subthalamic nucleus

Arquivos de Neuro-Psiquiatria, 2015
Nitric oxide (NO) is a major neurotransmitter associated with motor control in basal ganglia. Movement disorders, as essential tremor and Parkinson’s disease, are more prevalent on aged individuals.
Bruno Lopes dos Santos-Lobato, Elaine Aparecida Del-Bel, José Eymard Homem Pittella, Vitor Tumas   +3 more
doaj   +1 more source

Neuronal density for the tip region for the sinusoidal probe and microwire probe for 52 (A,B) and 96 (C,D) week time points.

, 2016
Increased neuronal density was found at 52 and 96 weeks for the flexible probe.
Gavin J. Clowry (49890), Stuart N. Baker (298109), Harbaljit S. Sohal (3279861), Anthony O’Neill (1326087), Andrew Jackson (376958)   +4 more
core   +1 more source

"Role of the neuronal protein Cap23 in the maturation and maintenance of dendritic arbors in-vivo" [PDF]

, 2006
Dendrites in the central nervous system are the postsynaptic counterparts in the neural circuitry, and the principal sites of excitatory synaptic inputs.
Sadhu, Anirban
core   +1 more source