Results 61 to 70 of about 300,344 (311)

HLXB9 gene expression, and nuclear location during in vitro neuronal differentiation in the SK-N-BE neuroblastoma cell line [PDF]

, 2014
Copyright @ 2014 Leotta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Federico, C, Leotta, CG, Tosi, S, Brundo, MV, Saccone, S   +4 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Neuronal induction and regional identity by co-culture of adherent human embryonic stem cells with chicken notochords and somites [PDF]

The role of somites and notochords in neuroectoderm differentiation from the embryonic ectoderm and its subsequent patterning into regional compartments along rostro-caudal and dorso-ventral axes, especially in humans, remains elusive.
سقا, محسن, رضوي, شهناز, صالحی, حسین, نصر اصفهاني, محمد حسين, کربلایی, خدیجه, نعمت الهی, مرضیه, بهاروند, حسين, تنهايي, سميه   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells

Molecular Brain, 2018
Pro-inflammatory cytokine interleukin-1 beta (IL-1β) is a key mediator of inflammation and stress in the central nervous system (CNS), and is highly expressed in the developing brain.
Shin-Young Park, Min-Jeong Kang, Joong-Soo Han   +2 more
doaj   +1 more source

NeuN As a Neuronal Nuclear Antigen and Neuron Differentiation Marker

Acta Naturae, 2015
The NeuN protein is localized in nuclei and perinuclear cytoplasm of most of the neurons in the central nervous system of mammals. Monoclonal antibodies to the NeuN protein have been actively used in the immunohistochemical research of neuronal differentiation to assess the functional state of neurons in norm and pathology for more than 20 years ...
Gusel'nikova, V., Korzhevskiy, D.
openaire   +3 more sources

Silica nanoparticle-exposure during neuronal differentiation modulates dopaminergic and cholinergic phenotypes in SH-SY5Y cells [PDF]

, 2019
Background Silica-ε-polycaprolactone-nanoparticles (SiPCL-NPs) represent a promising tool for laser-tissue soldering in the brain. After release of the SiPCL-NPs in the brain, neuronal differentiation might be modulated.
Martin Frenz, Wiedmer, Linda, Hans-Rudolf Widmer, Meike Mevissen, Linda Wiedmer, Widmer, Hans Rudolf, Mevissen, Meike, Frenz, Martin, Ducray, Angélique, Angélique D. Ducray, Michael H. Stoffel, Stoffel, Michael Hubert   +11 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Metabolic reprogramming during neuronal differentiation.

, 2016
Newly generated neurons pass through a series of well-defined developmental stages, which allow them to integrate into existing neuronal circuits. After exit from the cell cycle, postmitotic neurons undergo neuronal migration, axonal elongation, axon ...
Morone, N, F Romeo, Knight, RA, Melino G., Romeo, F, G Melino, Agostini, M, Mak, TW, Elia A. J., N Morone, Dinsdale, D., Elia, AJ, Romeo F., Melino, G., Niklison-Chirou, MV, T W Mak, Niklison-Chirou M. V., Melino, G, Mak T. W., Knight R. A., Agostini M., Inoue, S, Dinsdale D., Romeo, F., M Agostini, A J Elia, Inoue, S., Inoue S., Morone N., Niklison-Chirou, M. V., Dinsdale, D, Agostini, M., S Inoue, Mak, T. W., R A Knight, D Dinsdale, Knight, R. A., Elia, A. J., M V Niklison-Chirou, Morone, N.   +39 more
core   +1 more source