Results 51 to 60 of about 300,344 (311)

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation

, 2009
Objectives:  Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process.
Smulders-Srinivasan, T. K., Turnbull, Doug, Trevelyan, Andrew, Smulders-Srinivasan, Tora, Rennie, Katherine, Acin-Perez, Rebecca, Enriquez, J. A., Rennie, K. J., Lightowlers, R. N., Smulders-Srinivasan, T. K.; id_orcid, Kirby, D. M., Whittington, M., Trevelyan, A. J., Turnbull, D. M., Acin-Perez, R., Kirby, Denise, Lightowlers, Robert, Whittington, Miles, Enriquez, Jose   +18 more
core   +1 more source

BMAA effects neuronal differentiation.

, 2023
Treatment with all-trans retinoic acid (ATRA) induces neuronal differentiation of IMR-32 cells. Wnt enhances this process (A). Micrographs show neuronal differentiation of IMR-32 cells treated with BMAA and ATRA for 5 days (B).
Bryan Burton (14768907), Ellie Moore (14768919), Karly Marx (14768910), Kaylei Wilcox (14768916), Keith Osowski (14768922), Kate Collins (7193567), Jarron Rowe (14768928), Jordan Riley (14768925), Matthew Pawlus (14768931), Jordan Brooks (11151486), Abigail Renner (14768913)   +10 more
core   +1 more source

Non-catalytic roles for TET1 protein negatively regulating neuronal differentiation through srGAP3 in neuroblastoma cells

Protein & Cell, 2016
The methylcytosine dioxygenases TET proteins (TET1, TET2, and TET3) play important regulatory roles in neural function. In this study, we investigated the role of TET proteins in neuronal differentiation using Neuro2a cells as a model.
Jie Gao, Yue Ma, Hua-Lin Fu, Qian Luo, Zhen Wang, Yu-Huan Xiao, Hao Yang, Da-Xiang Cui, Wei-Lin Jin   +8 more
doaj   +1 more source

Neuronal differentiation and neurodegeneration: the role of Nogo-A?

, 2022
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. One of the main characteristics of this disorder is the degenerative loss of midbrain dopaminergic (DAergic) neurons of the substantia nigra pars compacta (SNpc ...
Lanci, Luigina
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Caveolin-1 plays a crucial role in inhibiting neuronal differentiation of neural stem/progenitor cells via VEGF signaling-dependent pathway. [PDF]

PLoS ONE, 2011
In the present study, we aim to elucidate the roles of caveolin-1(Cav-1), a 22 kDa protein in plasma membrane invaginations, in modulating neuronal differentiation of neural progenitor cells (NPCs).
Yue Li, Jianmin Luo, Wui-Man Lau, Guoqing Zheng, Shuping Fu, Ting-Ting Wang, He-Ping Zeng, Kwok-Fai So, Sookja Kim Chung, Yao Tong, Kejian Liu, Jiangang Shen   +11 more
doaj   +1 more source

p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death [PDF]

, 2005
In large models of neuronal cell death, there is a tight correlation between Cdk5 deregulation and cell-cycle dysfunction. However, pathways that link Cdk5 to the cell cycle during neuronal death are still unclear.
Sambo, Anne-Véronique, Philippe Bertrand, Bégard, Séverine, Luc Buée, André Delacourte, Séverine Bégard, Bertrand, Philippe, Hamdane, Malika, Katharina Schindowski, Bretteville, Alexis, Anne-Véronique Sambo, Schindowski, Katharina, Delacourte, André, Buée, Luc, Malika Hamdane, Alexis Bretteville   +15 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The effect of in vitro culture on the stability, expansion and neuronal differentiation of human pluripotent cell lines [PDF]

, 2010
Pluripotent cells are defined by their ability to both self-renew and to differentiation into any cell type within the human body. As such, pluripotent cell lines are of great interest as starting material for drug screening and cell therapies for ...
Gillett, M L, Gillett, M.L.
core  

Purification of Immature Neuronal Cells from Neural Stem Cell Progeny [PDF]

Large-scale proliferation and multi-lineage differentiation capabilities make neural stem cells (NSCs) a promising renewable source of cells for therapeutic applications.
Brent A Reynolds, اسفندياري, ابراهيم, Reynolds, Brent A, Maryam Rahman, Osborne, Geoffrey W, Dennis A Steindler, Adams, David J, Dennis A. Steindler, Takahiro Yasuda, Bjorn Scheffler, Brent A. Reynolds, Scheffler, Bjorn, Mohammad G Golmohammadi, گل محمدی, محمد قاسم, Geoffrey W Osborne, Hassan Azari, David J. Adams, Mohammad G. Golmohammadi, Deleyrolle, Loic P, Steindler, Dennis A, Ebrahim Esfandiari, Loic P Deleyrolle, آذری, حسن, Yasuda1, Takahiro, رحمان, مریم, David J Adams, Loic P. Deleyrolle, Geoffrey W. Osborne   +27 more
core   +1 more source