Results 41 to 50 of about 300,344 (311)

CIC is a Critical Regulator of Neuronal Differentiation [PDF]

JCI Insight, 2019
ABSTRACT Capicua (CIC), a member of the high mobility group (HMG)-box superfamily of transcriptional repressors, is frequently mutated in human oligodendrogliomas. But its function in brain development and tumorigenesis remains poorly understood. Here, we report that brain-specific deletion of Cic
Inah Hwang, Heng Pan, Jun Yao, Olivier Elemento, Hongwu Zheng, Jihye Paik   +5 more
openaire   +3 more sources

Cellular Acetylcholine Content and Neuronal Differentiation [PDF]

Journal of Neurochemistry, 1997
Abstract: N18TG2 neuroblastoma clone is defective for biosynthetic neurotransmitter enzymes; its inability to establish functional synapses is overcome in the neuroblastoma × glioma 108CC15, where acetylcholine synthesis is also activated. These observations suggest a possible relation between the ability to produce acetylcholine and the capability to ...
F. Bignami, P. Bevilacqua, BIAGIONI, Stefano, DE JACO, Antonella, F. Casamenti, A. Felsani, TOCCO, Gabriella   +6 more
openaire   +5 more sources

A two-step strategy for neuronal differentiation in vitro of human dental follicle cells

, 2012
Human dental follicle cells (DFCs) derived from wisdom teeth are precursor cells for cementoblasts. In this study, we recognized that naive DFCs express constitutively the early neural cell marker b-IIItubulin.
Völlner, Florian
core   +1 more source

Ionizing Radiation Induces Altered Neuronal Differentiation by mGluR1 through PI3K-STAT3 Signaling in C17.2 Mouse Neural Stem-Like Cells. [PDF]

PLoS ONE, 2016
Most studies of IR effects on neural cells and tissues in the brain are still focused on loss of neural stem cells. On the other hand, the effects of IR on neuronal differentiation and its implication in IR-induced brain damage are not well defined.
Hyeon Soo Eom, Hae Ran Park, Sung Kee Jo, Young Sang Kim, Changjong Moon, Sung-Ho Kim, Uhee Jung   +6 more
doaj   +1 more source

iASPP regulates neurite development by interacting with Spectrin proteins

Frontiers in Molecular Neuroscience, 2023
IntroductionSince its discovery in 1999, a substantial body of research has shown that iASPP is highly expressed in various kinds of tumors, interacts with p53, and promotes cancer cell survival by antagonizing the apoptotic activity of p53. However, its
Junhao Wang, Chunhong Jia, Qiong Gao, Jiwen Zhang, Xi Gu   +4 more
doaj   +1 more source

Unidirectional Neuronal Cell growth and Differentiation on Aligned Polyhydroxyalkanoate Blend Microfibres with Varying Diameters [PDF]

, 2019
Polyhydroxyalkanoates (PHAs) are a family of prokaryotic-derived biodegradable and biocompatible natural polymers known to exhibit neuroregenerative properties. In this work, poly(3-hydroxybutyrate), P(3HB) and poly(3-hydroxyoctanoate), P(3HO), have been
Lizarraga Valderrama, L., Lizarraga‐Valderrama, L.R., Claeyssens, F., Claeyssens, F, Knowles, J.C., Roy, I., Knowles, JC, Lizarraga-Valderrama, LR, Roy, I, Taylor, C.S., Haycock, JW, Taylor, CS, Haycock, J.W.   +12 more
core   +1 more source

Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles

Molecules, 2019
Neurodegenerative diseases are characterized by oxidative stress, mitochondrial damage, and death of neuronal cells. To counteract such damage and to favor neurogenesis, neurotrophic factors could be used as therapeutic agents. Octadecaneuropeptide (ODN),
Amira Namsi, Thomas Nury, Amira. S. Khan, Jérôme Leprince, David Vaudry, Claudio Caccia, Valerio Leoni, Atanas G. Atanasov, Marie-Christine Tonon, Olfa Masmoudi-Kouki, Gérard Lizard   +10 more
doaj   +1 more source

Regulation of boundary cap neural crest stem cell differentiation after transplantation [PDF]

, 2009
Success of cell replacement therapies for neurological disorders will depend largely on the optimization of strategies to enhance viability and control the developmental fate of stem cells after transplantation.
Hjerling-Leffler, J, Aldskogius, Hakan, Wegner, M, Hjerling-Leffler, Jens, Kozlova, Elena N, Medvinsky, Alexander, Berens, C, Aldskogius, H, Kozlova, EN, Berens, Christian, Kanaykina, Nadezda, Sandelin, Martin, Schreiner, S, Wegner, Michael, Kanaykina, N, Sandelin, M, Liakhovitskaia, A, Medvinsky, A, Liakhovitskaia, Anna, Schreiner, Silke   +19 more
core   +1 more source

Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

eLife, 2016
Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans.
Damien Lanfray, Alexandre Caron, Marie-Claude Roy, Mathieu Laplante, Fabrice Morin, Jérôme Leprince, Marie-Christine Tonon, Denis Richard   +7 more
doaj   +1 more source

Upregulation of Apol8 by Epothilone D facilitates the neuronal relay of transplanted NSCs in spinal cord injury

Stem Cell Research & Therapy, 2021
Background Microtubule-stabilizing agents have been demonstrated to modulate axonal sprouting during neuronal disease. One such agent, Epothilone D, has been used to treat spinal cord injury (SCI) by promoting axonal sprouting at the lesion site after ...
Weiwei Xue, Haipeng Zhang, Yongheng Fan, Zhifeng Xiao, Yannan Zhao, Weiyuan Liu, Bai Xu, Yanyun Yin, Bing Chen, Jiayin Li, Yi Cui, Ya Shi, Jianwu Dai   +12 more
doaj   +1 more source