Results 71 to 80 of about 470,748 (305)

A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries [PDF]

, 2020
Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche
A Buffo, A Kamezaki, A Torroglosa, AC Newton, AC Rice, AX Wu-Zhang, BT Susarla, C Kilkenny, C Romero-Grimaldi, CP Blobel, DC Lee, DR Marks, E Flores-Giubi, EK Adrian Jr., ES Anton, F Doetsch, F Garcia-Bernal, FH Gage, GJ Francis, HG Kuhn, HT Ghashghaei, I Comte, J Fallon, J Liu, J Wang, JB Cavanagh, JC McGrath, JM Verdi, K Blennow, K Jin, L Avila, LG Rabaneda, LG Rabaneda, M Carrasco, M Dang, M Dang, M Fatt, M Murillo-Carretero, N Geribaldi-Doldan, N Geribaldi-Doldan, ND Zhao, O Gonzalez-Perez, PK Dash, RG Thorne, S Chirumamilla, S Dominguez-Garcia, SW Sunnarborg, V Tropepe, Y Kim   +48 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Effects of silica nanoparticle exposure on mitochondrial function during neuronal differentiation

Journal of Nanobiotechnology, 2017
Background Nanomedicine offers a promising tool for therapies of brain diseases, but potential effects on neuronal health and neuronal differentiation need to be investigated to assess potential risks.
Angélique D. Ducray, Andrea Felser, Jana Zielinski, Aniela Bittner, Julia V. Bürgi, Jean-Marc Nuoffer, Martin Frenz, Meike Mevissen   +7 more
doaj   +1 more source

Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiation [PDF]

, 2000
During the development of the vertebrate nervous system, neurogenesis is promoted by proneural bHLH proteins such as the neurogenins, which act as potent transcriptional activators of neuronal differentiation genes.
Anderson­, David J., Kim, Jaesang, Kintner, Chris, Koyano-Nakagawa, Naoko   +3 more
core  

Fractional differentiation by neocortical pyramidal neurons [PDF]

Nature Neuroscience, 2008
Neural systems adapt to changes in stimulus statistics. However, it is not known how stimuli with complex temporal dynamics drive the dynamics of adaptation and the resulting firing rate. For single neurons, it has often been assumed that adaptation has a single time scale.
Lundstrom, Brian Nils, Higgs, Matthew H, Spain, William J, Fairhall, Adrienne L   +3 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells [PDF]

, 2002
In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for sensory and autonomic neurogenesis, respectively.
Anderson, David J., Dormand, Emma, Greenwood, Amy, Lo, Liching   +3 more
core  

A zinc transporter gene required for development of the nervous system. [PDF]

, 2013
The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous ...
Chowanadisai, Winyoo, Graham, David M, Keen, Carl L, Messerli, Mark A, Rucker, Robert B   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity [PDF]

, 1998
We have investigated the genetic circuitry underlying the determination of neuronal identity, using mammalian peripheral autonomic neurons as a model system.
Anderson, David J., Lo, Liching, Tiveron, Marie-Catherine   +2 more
core