Results 71 to 80 of about 1,427,821 (305)

Bag1 is a regulator and marker of neuronal differentiation [PDF]

Cell Death & Differentiation, 2002
Bag 1 acts as a co-chaperone for Hsp70/Hsc70. We report here that stable over-expression of Bag1 in immortalized neuronal CSM14.1 cells prevents death following serum deprivation. Bag1 over-expression slowed the proliferative rate of CSM14.1 cells, resulted in increased levels of phospo-MAP kinases and accelerated neuronal differentiation ...
P, Kermer, M, Krajewska, J M, Zapata, S, Takayama, J, Mai, S, Krajewski, J C, Reed   +6 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Methods affecting neuronal differentiation of human adult and pluripotent stem cells [PDF]

, 2015
Stem cells have significant potential to treat many age-related degenerative disorders that affect increasing numbers of people globally. This thesis investigated the capacity for omnicytes and human pluripotent stem cells (hPSC) to undergo directed ...
Thwaites, JW
core  

TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons. [PDF]

, 2014
Members of the transforming growth factor (TGF)-b family govern a wide range of mechanisms in brain development and in the adult, in particular neuronal/glial differentiation and survival, but also cell cycle regulation and neural stem cell maintenance ...
Strauss, O., Aigner, L., Lehner, B., Kraus, Sabrina, Strauss, Olaf, Reitsamer, Herbert A., Marschallinger, Julia, Lehner, Bernadette, Couillard-Despres, Sebastien, Bogdahn, Ulrich, Couillard‐Despres, Sebastien, Kandasamy, M., Kraus, S., Couillard-Despres, S., Sander, P.R., Trümbach, Dietrich, Aigner, Ludwig, Bogdahn, U., Trümbach, D., Sander, Paul Ramm, Ramm Sander, Paul, Rivera, Francisco J., Ueberham, Uwe, Marschallinger, J., Kandasamy, Mahesh, Reitsamer, H.A., Rivera, F.J., Ueberham, U.   +27 more
core   +1 more source

Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation

Neural Regeneration Research, 2020
Extracellular matrix (ECM) influences cell differentiation through its structural and biochemical properties. In nervous system, neuronal behavior is influenced by these ECMs structures which are present in a meshwork, fibrous, or tubular forms ...
Deepak Jain, Sabrina Mattiassi, Eyleen L Goh, Evelyn K.F. Yim   +3 more
doaj   +1 more source

Epilepsy-Induced Motility of Differentiated Neurons [PDF]

Cerebral Cortex, 2013
Neuronal ectopia, such as granule cell dispersion (GCD) in temporal lobe epilepsy (TLE), has been assumed to result from a migration defect during development. Indeed, recent studies reported that aberrant migration of neonatal-generated dentate granule cells (GCs) increased the risk to develop epilepsy later in life.
Chai, Xuejun, Münzner, Gert, Zhao, Shanting, Tinnes, Stefanie, Kowalski, Janina, Häussler, Ute, Young, Christina, Haas, Carola, Frotscher, Michael   +8 more
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Silica nanoparticle-exposure during neuronal differentiation modulates dopaminergic and cholinergic phenotypes in SH-SY5Y cells [PDF]

, 2019
Background Silica-ε-polycaprolactone-nanoparticles (SiPCL-NPs) represent a promising tool for laser-tissue soldering in the brain. After release of the SiPCL-NPs in the brain, neuronal differentiation might be modulated.
Martin Frenz, Wiedmer, Linda, Hans-Rudolf Widmer, Meike Mevissen, Linda Wiedmer, Widmer, Hans Rudolf, Mevissen, Meike, Frenz, Martin, Ducray, Angélique, Angélique D. Ducray, Michael H. Stoffel, Stoffel, Michael Hubert   +11 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source