Results 91 to 100 of about 1,427,821 (305)
RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development [PDF]
, 2010 Background: Early inner ear development requires the strict regulation of cell proliferation, survival, migration and differentiation, coordinated by the concerted action of extrinsic and intrinsic factors.
Rapp Ulf R. +21 more
core +2 more sources
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
, 2010 [[abstract]]Enhancer of zeste homolog 2 (EZH2), a polycomb group (PcG) protein, regulates stem cells renewal and differentiation. Phosphatidylinositol-4-phosphate 5-kinase, type I gamma (PIP5K1C) plays an important role in synthesis of ...
Ling-Tzu Chen
core
FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways
Frontiers in Cellular Neuroscience, 2014 FOXP2 was the first gene shown to cause a Mendelian form of speech and language disorder. Although developmentally expressed in many organs, loss of a single copy of FOXP2 leads to a phenotype that is largely restricted to orofacial impairment during ...
Paolo eDevanna +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Nature CommunicationsNeuronal differentiation—the development of neurons from neural stem cells—involves neurite outgrowth and is a key process during the development and regeneration of neural functions.
Shunsuke Chuma +8 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
A method for siRNA-mediated knockdown of target genes in RA-induced neurogenesis using P19 cells
MethodsXThis study presents a comprehensive protocol for siRNA-mediated knockdown in the differentiation of P19 cells into neuronal-like cells. Utilizing a retinoic acid (RA)-induced neurogenesis model, P19 cells were cultured under specific conditions that ...
Hossein Khodadadi, Hiroaki Taniguchi
doaj +1 more source
The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation
Frontiers in Molecular Neuroscience, 2019 Luteolin, a polyphenolic plant flavonoid, has been attributed with numerous beneficial properties like anti-cancer, antioxidant, and anti-inflammatory action.
Amrutha Swaminathan +7 more
doaj +1 more source
Stem Cell Research & Therapy, 2020 Introduction Stem cell transplantation of exogenous neural progenitor cells (NPCs) derived from mesenchymal stem cells (MSCs) has emerged as a promising approach for neurodegenerative disease.
Anupong Songsaad +4 more
doaj +1 more source