Results 91 to 100 of about 470,748 (305)

Improvement of neuronal differentiation by carbon monoxide: Role of pentose phosphate pathway

Redox Biology, 2018
Over the last decades, the silent-killer carbon monoxide (CO) has been shown to also be an endogenous cytoprotective molecule able to inhibit cell death and modulate mitochondrial metabolism.
Ana S. Almeida, Nuno L. Soares, Catarina O. Sequeira, Sofia A. Pereira, Ursula Sonnewald, Helena L.A. Vieira   +5 more
doaj   +1 more source

Determination of transmitter function by neuronal activity [PDF]

, 1977
The role of neuronal activity in the determination of transmitter function was studied in cultures of dissociated sympathetic neurons from newborn rat superior cervical ganglia.
Campenot, Robert B., Patterson, Paul H., Walicke, Patricia A.   +2 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways

Frontiers in Cellular Neuroscience, 2014
FOXP2 was the first gene shown to cause a Mendelian form of speech and language disorder. Although developmentally expressed in many organs, loss of a single copy of FOXP2 leads to a phenotype that is largely restricted to orofacial impairment during ...
Paolo eDevanna, Jeroen eMiddelbeek, Sonja Catherine Vernes, Sonja Catherine Vernes   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation

Frontiers in Molecular Neuroscience, 2019
Luteolin, a polyphenolic plant flavonoid, has been attributed with numerous beneficial properties like anti-cancer, antioxidant, and anti-inflammatory action.
Amrutha Swaminathan, Amrutha Swaminathan, Moumita Basu, Abdelhamid Bekri, Abdelhamid Bekri, Pierre Drapeau, Pierre Drapeau, Tapas K. Kundu   +7 more
doaj   +1 more source

Potential of resveratrol in enrichment of neural progenitor-like cell induction of human stem cells from apical papilla

Stem Cell Research & Therapy, 2020
Introduction Stem cell transplantation of exogenous neural progenitor cells (NPCs) derived from mesenchymal stem cells (MSCs) has emerged as a promising approach for neurodegenerative disease.
Anupong Songsaad, Thanasup Gonmanee, Nisarat Ruangsawasdi, Chareerut Phruksaniyom, Charoensri Thonabulsombat   +4 more
doaj   +1 more source

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression [PDF]

, 2015
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are ...
AC Thénié, B Holmqvist, B Kuzin, B Moreno-Lopez, BL Sopher, C-H Cheng, D Dahary, DS Bredt, E Ciani, E Pavesi, GB Robb, J Chen, J Garthwaite, J-T Li, JB Kelley, JE Fish, JH Brann, K Matsui, KY Kwan, L Zhou, MA Faghihi, MA Packer, ME Evangelopoulos, ME Evangelopoulos, MHT Ling, N Peunova, P Ogilvie, RG Tremblay, S Hindley, S Korneev, SA Korneev, SA Korneev, SA Korneev, SA Korneev, SM Gibbs, SR Vincent, U Forstermann, V Calabrese, Y Zhang   +38 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature

Nature Communications
Neuronal differentiation—the development of neurons from neural stem cells—involves neurite outgrowth and is a key process during the development and regeneration of neural functions.
Shunsuke Chuma, Kazuyuki Kiyosue, Taishu Akiyama, Masaki Kinoshita, Yukiho Shimazaki, Seiichi Uchiyama, Shingo Sotoma, Kohki Okabe, Yoshie Harada   +8 more
doaj   +1 more source