Results 1 to 10 of about 274,989 (217)

Regional Development of Glioblastoma: The Anatomical Conundrum of Cancer Biology and Its Surgical Implication

Cells, 2022
Glioblastoma (GBM) are among the most common malignant central nervous system (CNS) cancers, they are relatively rare. This evidence suggests that the CNS microenvironment is naturally equipped to control proliferative cells, although, rarely, failure of
Ciro De Luca, Assunta Virtuoso, Michele Papa, Francesco Certo, Giuseppe Maria Vincenzo Barbagallo, Roberto Altieri   +5 more
doaj   +1 more source

Investigating Communication Dynamics in Neuronal Network using 3D Gold Microelectrode Arrays [PDF]

ACS Nano
Yaoyao Liu, Andrew Glidle, Shihong Xu
exaly   +2 more sources

Super-Selective Reconstruction of Causal and Direct Connectivity With Application to in vitro iPSC Neuronal Networks

Frontiers in Neuroscience, 2021
Despite advancements in the development of cell-based in-vitro neuronal network models, the lack of appropriate computational tools limits their analyses.
Francesca Puppo, Deborah Pré, Anne G. Bang, Gabriel A. Silva   +3 more
doaj   +1 more source

Loss of calsyntenin paralogs disrupts interneuron stability and mouse behavior

Molecular Brain, 2022
Calsyntenins (CLSTNs) are important synaptic molecules whose molecular functions are not fully understood. Although mutations in calsyntenin (CLSTN) genes have been associated with psychiatric disorders in humans, their function is still unclear.
Keita Mori, Michinori Koebis, Kazuki Nakao, Shizuka Kobayashi, Yuji Kiyama, Masahiko Watanabe, Toshiya Manabe, Yuichi Iino, Atsu Aiba   +8 more
doaj   +1 more source

Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning

Molecular Brain, 2020
Protrudin is a protein that resides in the membrane of the endoplasmic reticulum and is highly expressed in the nervous system. Although mutations in the human protrudin gene (ZFYVE27, also known as SPG33) give rise to hereditary spastic paraplegia (HSP),
Michiko Shirane, Hirotaka Shoji, Yutaka Hashimoto, Hiroyuki Katagiri, Shizuka Kobayashi, Toshiya Manabe, Tsuyoshi Miyakawa, Keiichi I. Nakayama   +7 more
doaj   +1 more source

The Synchronization Behaviors of Memristive Synapse-Coupled Fractional-Order Neuronal Networks

IEEE Access, 2021
The synchronization behaviors of memristive synapse-coupled fractional-order neuronal networks are investigated in this paper. Based on the integer-order memristive synapse-coupled neuronal network, a fractional-order model is proposed, and a ring ...
Yang Xin, Zhang Guangjun
doaj   +1 more source

Physically real and virtual reality exposed line bisection response patterns: visuospatial attention allocation in virtual reality

Frontiers in Psychology, 2023
IntroductionTo understand the nature of hemispatial attention allocation in virtual reality (VR), a line bisection task (LBT) was administered both in a real environment and a virtual environment to assess the rate of pseudoneglect.
János Kállai, Tamás Páll, Kristóf Topa, András Norbert Zsidó   +3 more
doaj   +1 more source

Noradrenaline Increases mEPSC Frequency in Pyramidal Cells in Layer II of Rat Barrel Cortex via Calcium Release From Presynaptic Stores

Frontiers in Cellular Neuroscience, 2018
Somatosensory cortex is innervated by afferents originating from the locus coeruleus which typically release noradrenaline. We tested if activation of presynaptic α1-adrenoceptors (AR) coupled to a Gq-mediated signaling cascade resulted in calcium (Ca2+)
Julian M. C. Choy, Fransiscus A. Agahari, Fransiscus A. Agahari, Li Li, Li Li, Christian Stricker, Christian Stricker   +6 more
doaj   +1 more source

Scale-Free Dynamics in Animal Groups and Brain Networks

Frontiers in Systems Neuroscience, 2021
Collective phenomena fascinate by the emergence of order in systems composed of a myriad of small entities. They are ubiquitous in nature and can be found over a vast range of scales in physical and biological systems.
Tiago L. Ribeiro, Dante R. Chialvo, Dante R. Chialvo, Dietmar Plenz   +3 more
doaj   +1 more source

SNAP-25 phosphorylation at Ser187 regulates synaptic facilitation and short-term plasticity in an age-dependent manner

Scientific Reports, 2017
Neurotransmitter release is mediated by the SNARE complex, but the role of its phosphorylation has scarcely been elucidated. Although PKC activators are known to facilitate synaptic transmission, there has been a heated debate on whether PKC mediates ...
Norikazu Katayama, Saori Yamamori, Masahiro Fukaya, Shizuka Kobayashi, Masahiko Watanabe, Masami Takahashi, Toshiya Manabe   +6 more
doaj   +1 more source